The brainstem auditory evoked potential abnormalities in severe chronic obstructive pulmonary disease

Atış, Sibel; Özge, Aynur; Sevi.M, Serhan

doi:10.1046/j.1440-1843.2001.00337.x

Cited by 19 publications

(17 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They have not described the details of the inclusion and irreversibility criteria. Atis et al [5] included 21 patients with severe COPD according to the criteria[15] of the American Thoracic Society (1987). Some of the patients included had clinical evidence of neuropathy.…”

Section: Discussionmentioning

confidence: 99%

“…[4] Atis and co-workers studied BAEP in patients with severe COPD and concluded that eighth cranial nerve and brainstem functions were impaired in COPD. [5] Barbieri et al reported that there was no significant difference in BAEP in mild-or-moderate chronic respiratory insufficiency, apart from acidosis. [6] It appears the previous studies have included COPD patients having severe airflow obstruction or significant hypoxemia/hypercapnia.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of brain stem auditory evoked potentials in stable patients with chronic obstructive pulmonary disease

et al. 2008

View full text Add to dashboard Cite

Though there are few studies addressing brainstem auditory evoked potentials (BAEP) in patients with chronic obstructive pulmonary disease (COPD), subclinical BAEP abnormalities in stable COPD patients have not been studied. The present study aimed to evaluate the BAEP abnormalities in this study group.MATERIALS AND METHODS:In the present study, 80 male subjects were included: COPD group comprised 40 smokers with stable COPD with no clinical neuropathy; 40 age-matched healthy volunteers served as the control group. Latencies of BAEP waves I, II, III, IV, and V, together with interpeak latencies (IPLs) of I-III, I-V, and III-V, and amplitudes of waves I-Ia and V-Va were studied in both the groups to compare the BAEP abnormalities in COPD group; the latter were correlated with patient characteristics and Mini–Mental Status Examination Questionnaire (MMSEQ) scores to seek any significant correlation.RESULTS:Twenty-six (65%) of the 40 COPD patients had BAEP abnormalities. We observed significantly prolonged latencies of waves I, III, V over left ear and waves III, IV, V over right ear; increased IPLs of I-V, III-V over left ear and of I-III, I-V, III-V over right side. Amplitudes of waves I-Ia and V-Va were decreased bilaterally. Over left ear, the latencies of wave I and III were significantly correlated with FEV1; and amplitude of wave I-Ia, with smoking pack years. A weak positive correlation between amplitude of wave I-Ia and duration of illness; and a weak negative correlation between amplitude of wave V-Va and MMSEQ scores were seen over right side.CONCLUSIONS:We observed significant subclinical BAEP abnormalities on electrophysiological evaluation in studied stable COPD male patients having mild-to-moderate airflow obstruction.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Evaluation of brain stem auditory evoked potentials in stable patients with chronic obstructive pulmonary disease

et al. 2008

View full text Add to dashboard Cite

show abstract

“…In the rat, the acoustic nerve generates peak I, the cochlear nucleus peak II, the superior olivary nucleus peak III, the lateral lemniscus peak IV, and the inferior colliculus peak V (30). Increased interpeak intervals may be an indication of anomalous myelination or nerve conduction as well as brainstem, thalamic, and͞or cortical deficits (31,32). Cochlear and brainstem auditory nuclei are highly sensitive to oxygen shortage (25,33).…”

Section: Discussionmentioning

confidence: 99%

Perinatal anoxia degrades auditory system function in rats

Strata

Deipolyi²,

Bonham³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Little is known about the neural bases of the reduced auditory and cortical processing speeds that have been recorded in languageimpaired, autistic, schizophrenic, and other disabled human populations. Although there is strong evidence for genetic contributions to etiologies, epigenetic factors such as perinatal anoxia (PA) have been argued to be contributors, or causal, in a significant proportion of cases. In this article, we explored the consequences of PA on this elementary aspect of auditory behavior and on auditory system function in rats that were briefly perinatally anoxic. PA rats had increased acoustic thresholds and reduced processing efficiencies recorded in an auditory behavioral task. These rats had modestly increased interpeak intervals in their auditory brainstem responses, and substantially longer latencies in poststimulus time histogram responses recorded in the primary auditory cortex. The latter were associated with degraded primary auditory cortex receptive fields and a disrupted tonotopy. These processing deficits are consistent with the parallel behavioral and physiological deficits recorded in children and adults with a history of language-learning impairment and autism.auditory behavior ͉ auditory brainstem responses ͉ auditory cortex ͉ autism ͉ language learning impairment

show abstract

“…Kotterba et al analyzing data relative to 20 patients affected by severe OSAS, found prolongations of wave latency I ( P B 0.001) and interpeak latency I-V (P B 0.001) in the 60 % of the total sample, with 9 (45 %) subjects characterized by pontomesencephal lesions [13]. The auditory pathway sensitiveness to reduced oxygen levels was also investigated by Atiş et al who recorded the ABR of 21 patients with severe chronic obstructive pulmonary disease, with the 76.1 % of the sample showing ABR abnormalities like prolonged wave I peak latencies (42.8 %), wave V peak latencies (38.1 %) and III-V interpeak latencies (38.1 %) [14]. Recently Casale et al comparing audiological data of 18 patients with severe OSAS and 21 simple snoring subjects, evidenced prolonged mean latencies of waves I, III, V (P \ 0.05) and a significantly (P \ 0.01) higher pure-tone audiometry (PTA) in OSAS group with respect to healthy people [15].…”

Section: Introductionmentioning

confidence: 99%

Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function

Martines

Ballacchino

Sireci

et al. 2015

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The objective of this work was to study the effect of nocturnal intermittent hypoxia on auditory function of simple snoring patients and subjects affected by OSAS; we compared the audiologic profile with the severity of OSAS to detect early signs of cochlear damage. One hundred-sixty patients underwent overnight polysomnography, micro-otoscopy, multi-frequency audiometry, acufenometry, TEOAE recording and d-ROMs test. All subjects were divided in four groups, based on presence/absence of AHI (simple snoring without OSAS, mild OSAS, moderate OSAS, severe OSAS). Sixty (37.5 %) patients were not affected by OSAS, 58 (36.25 %) presented a mild OSAS, 18 (11.25 %) a moderate OSAS and 24 (15 %) a severe OSAS; the 57.14 % of moderate to severe OSAS suffered from tinnitus with respect to the 31.03 % of mild OSAS (P = 0.024). A higher percentage (41.66 %) of hearing loss was found among individuals with moderate to severe degree of OSAS (P \ 0.0001). All groups were characterized by a mean hearing threshold \25 dB HL for 0.25-3 kHz frequencies and a progressive decrease in hearing sensitivity, particularly for 6-16 kHz frequencies (P \ 0.05). The analysis of otoacoustic emissions SNR mean values evidenced a significant difference between simple snoring and severe OSAS individuals for 3 and 4 kHz frequencies (P \ 0.05). d-ROM levels resulted higher in patients with severe OSAS with respect to simple snoring subjects (P = 0.004). Our data underline the key role of chronic nocturnal intermittent hypoxia in the development of an early cochlear damage and a more marked high-frequency hearing loss in case of severe OSAS (P \ 0.05).

show abstract

The brainstem auditory evoked potential abnormalities in severe chronic obstructive pulmonary disease

Abstract: The functions of the eighth cranial nerve and brainstem were highly impaired in severe COPD. These pathological BAEP alterations in severe COPD might be due to the chronic hypoxic-hypercapnic status occurring in the brainstem.

Cited by 19 publications

References 14 publications

Evaluation of brain stem auditory evoked potentials in stable patients with chronic obstructive pulmonary disease

Evaluation of brain stem auditory evoked potentials in stable patients with chronic obstructive pulmonary disease

Perinatal anoxia degrades auditory system function in rats

Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function

Contact Info

Product

Resources

About