The brake matters: Hyperexcitable arousal circuits in sleep fragmentation with age

Li, Shi-Bin; Lecea, Luı́s de

doi:10.1002/ctm2.900

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Regarding general (not specifically REM) sleep fragmentation, there is growing evidence of a link between sleep instability and pain sensitivity (Iacovides et al, 2017; Koh et al, 2015; Sutton & Opp, 2014). Furthermore, a general increase with age should be noted (Li & de Lecea, 2022; Scullin & Bliwise, 2015).…”

Section: Correlates Of Psg Defined Sleep Instabilitymentioning

confidence: 99%

Insomnia and REM sleep instability

Feige,

Benz,

Dressle

et al. 2023

Journal of Sleep Research

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SummaryIn this narrative review, we give an overview of the concept of rapid eye movement sleep instability and its reported implications in the context of insomnia. The term rapid eye movement sleep instability was coined to describe the observation of a modified rapid eye movement quality in insomnia, characterized by an increased tendency of perceiving rapid eye movement sleep as wake, a small but consistent rapid eye movement sleep reduction and an increased rapid eye movement sleep arousal index. Current research highlights relationships that are transdiagnostic in nature, corresponding to the known interaction of insomnia with many psychiatric disorders, and showing relationships to chronic stress and anxiety disorders.

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Section: Correlates Of Psg Defined Sleep Instabilitymentioning

confidence: 99%

Insomnia and REM sleep instability

Feige,

Benz,

Dressle

et al. 2023

Journal of Sleep Research

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“…Acute sleep deprivation is becoming a prevalent public health concern because of its adverse effects on human health and quality of life, such as an increased the risk of cardiovascular disease [8], reduced respiratory motor performance [9], inducing cognitive deficits [10] and linking with immune deregulation [11]. People experience acute sleep deprivation owing to many factors, including aging, stress and sleep disorders [12][13][14].…”

mentioning

confidence: 99%

The effect of acute sleep deprivation on cortisol level: a systematic review and meta-analysis

Chen,

Xu,

Chen

et al. 2024

Endocr J

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Acute sleep deprivation has aroused widespread concern and the relationship between acute sleep deprivation and cortisol levels is inconsistent. This study aimed to explore additional evidence and details. The PubMed, Web of Science, EMBASE, CLINAHL and Cochrane databases were searched for eligible studies published up to June 7, 2023. All analyses were performed using Review Manager 5.4 and Stata/SE 14.0. A total of 24 studies contributed to this meta-analysis. There was no significant difference in cortisol levels between participants with acute sleep deprivation and normal sleep in 21 crossover-designed studies (SMD = 0.18; 95% CI: -0.11, 0.45; p = 0.208) or 3 RCTs (SMD = 0.26; 95% CI: -0.22, 0.73; p = 0.286). Subgroup analysis revealed that the pooled effects were significant for studies using serum as the sample (SMD = 0.46; 95%CI: 0.11, 0.81; p = 0.011). Studies reporting cortisol levels in the morning, in the afternoon and in the evening did not show significant difference (p > 0.05). The pooled effects were statistically significant for studies with multiple measurements (SMD = 0.28; 95%CI: 0.03, 0.53; p = 0.027) but not for studies with single cortisol assessments (p = 0.777). When the serum was used as the test sample, the cortisol levels of individuals after acute sleep deprivation were higher than those with normal sleep.

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The brake matters: Hyperexcitable arousal circuits in sleep fragmentation with age

Cited by 2 publications

References 19 publications

Insomnia and REM sleep instability

Insomnia and REM sleep instability

The effect of acute sleep deprivation on cortisol level: a systematic review and meta-analysis

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