From being a net food importer in recent decades, Brazil is now considered a successful case of agricultural production and export. However, this image of triumph and efficiency helps to conceal growing socio-ecological impacts and mounting uneasiness. The complex and contradictory landscape of contemporary Brazilian agribusiness represent a relevant example of the advance of agro-neoliberalism, which is both an economic and technological process of agriculture modernization and intensification, in accordance to liberalizing pressures, and also a politico-ecological phenomenon centred on market-based solutions to old and new production, innovation and justification questions. Based on qualitative research and three fieldwork campaigns, the article discusses recent politico-economic adjustments particularly in the State of Mato Grosso, in the Centre-West region, which is fast becoming the main area of agribusiness activity in the country. Empirical results demonstrate that agro-neoliberalism has been promoted through inventive public-private associations not for the purpose of domestic food security, but primarily for capital accumulation and to support sectoral interests and macroeconomic strategies.