SummaryThis article explores the impact of the ‘Quadruple Whammy’ consisting of Brexit, COVID‐19, Conflicts (Russia‐Ukraine and Israel‐Palestine) and Natural disasters on the food supply chain in Europe. This research adopted a two‐phase methodology comprised of the e‐Delphi technique followed by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) approach within the context of these four identified challenges. The objective of this article is to analyse the challenges faced by the European food supply chain due to these four factors. The article examines the impact of political isolationism such as Brexit on trade, cost and border controls, while also discussing the effects of COVID‐19 on labour, supply chains and the rise of e‐commerce. In addition, the article examines the impact of conflicts on food access and availability and the role of international aid and assistance. The effects of natural disasters, such as the Turkish and Moroccan earthquakes, floods in Spain and Portugal and the Moroccan drought, on food security are also analysed. The article offers several strategies for taming the quadruple whammy, such as investing in local food production and supply chains, diversifying supply chains and trade partnerships and strengthening food safety regulations and standards. The importance of building resilience and preparedness in the face of these challenges is emphasised and the article concludes with final thoughts and recommendations.