The Bridge Between Ischemic Stroke and Gut Microbes: Short-Chain Fatty Acids

Fang, Zuxiang; Chen, Mingrong; Qian, Jiafen; Wang, Chunhua; Zhang, Jinhua

doi:10.1007/s10571-022-01209-4

Cited by 14 publications

(19 citation statements)

References 185 publications

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“…SCFAs inhibit histone deacetylase (HDAC) activity and promote histone hyperacetylation. 102 An administration of 40 mg kg −1 of APG to MCAO rats significantly downregulated HDAC expression and increased acetylated H3 and acetylated H4 expression. 56 APG also decreases the thick-walled phylum/amastigotes ratio, increases the abundance of the Actinomycetes family, and increases the content of short-chain fatty acids.…”

Section: Mechanism Of Apg In the Prevention Of Cerebral Ischemiamentioning

confidence: 91%

“…And there is a need to further clarify whether SCFAs are mediators or bystanders in CI. 102 Finally, although APG is non-toxic, because no significant toxicity was found in mice given 300 mg kg −1 of APG for 68 consecutive days in the experiment. [114][115][116][117] APG still faces problems of adverse reactions and unclear adverse interactions with other drugs.…”

Section: Food and Function Reviewmentioning

confidence: 97%

“…SCFAs inhibit histone deacetylase (HDAC) activity and promote histone hyperacetylation. 102 An administration of…”

Section: Regulation Of Intestinal Microorganismsmentioning

confidence: 99%

See 2 more Smart Citations

|Therapeutic and preventive effects of apigenin in cerebral ischemia: a review

Wang

Zhao

et al. 2022

Food Funct.

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Section: Mechanism Of Apg In the Prevention Of Cerebral Ischemiamentioning

confidence: 91%

Section: Food and Function Reviewmentioning

confidence: 97%

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|Therapeutic and preventive effects of apigenin in cerebral ischemia: a review

Wang

Zhao

et al. 2022

Food Funct.

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“…Several studies have confirmed the efficacy and mechanism of probiotics in preventing CI by regulating the composition of the gut microbiota, improving intestinal barrier function, and regulating local and systemic immunity. Rodent models have verified the roles of Lactobacillus, Clostridium butyricum, and Bacillus licheniformis in CI (Fang et al, 2022). Through the regulation of TLR-4/NF-kappa B signaling, Lactobacillus reduced the extent of cerebral infarction, lowered oxidative stress, and blocked the death of brain cells, which improved neurobehavioral scores (Wanchao et al, 2018).…”

Section: Therapeutic Potentials Of Gut Microbiota In Cerebral Infarctionmentioning

confidence: 93%

The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction

Qian

et al. 2023

Front. Cell. Infect. Microbiol.

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As the most common type of stroke, ischemic stroke, also known as cerebral infarction (CI), with its high mortality and disability rate, has placed a huge burden on social economy and public health. Treatment methods for CI mainly include thrombectomy, thrombolysis, drug therapy, and so on. However, these treatments have certain timeliness and different side effects. In recent years, the gut-brain axis has become a hot topic, and its role in nervous system diseases has been confirmed by increasing evidences. The intestinal microbiota, as an important part of the gut-brain axis, has a non-negligible impact on the progression of CI through mechanisms such as inflammatory response and damage-associated molecular patterns, and changes in the composition of intestinal microbiota can also serve as the basis for predicting CI. At the same time, the diagnosis of CI requires more high-throughput techniques, and the analysis method of metabolomics just fits this demand. This paper reviewed the changes of intestinal microbiota in patients within CI and the effects of the intestinal microbiota on the course of CI, and summarized the therapeutic methods of the intervention with the intestinal microbiota. Furthermore, metabolic changes of CI patients were also discussed to reveal the molecular characteristics of CI and to elucidate the potential pathologic pathway of its interference.

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“…Patients with IS often experience complications such as gastrointestinal bleeding, microbiota imbalance, and constipation, which accelerates disease progression and worsens prognosis (Benakis et al, 2016;Kapil et al, 2017;Chen et al, 2019c;Li et al, 2019;Fralick et al, 2020;Pluta et al, 2021). In recent years, researchers have amassed findings that strongly suggest a dynamic association between the gut-brain axis and IS; this topic may become a new research hotspot, which could expedite identification of potential therapeutic targets and eventually result in an intervention that could improve the prognosis of IS (Battaglini et al, 2020;Sinagra et al, 2021;Fang et al, 2022;Peh et al, 2022). 10.3389/fnins.2023.1081347 The gut possesses both digestive and immunomodulatory functions while also hosting a microbial ecosystem.…”

Section: Introductionmentioning

confidence: 99%

Gut-brain axis: Mechanisms and potential therapeutic strategies for ischemic stroke through immune functions

Zhou

Guo²,

Yang³

et al. 2023

Front. Neurosci.

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After an ischemic stroke (IS) occurs, immune cells begin traveling to the brain and immune system from the gut and gastrointestinal tract, where most of them typically reside. Because the majority of the body’s macrophages and more than 70% of the total immune cell pool are typically found within the gut and gastrointestinal tract, inflammation and immune responses in the brain and immune organs require the mobilization of a large number of immune cells. The bidirectional communication pathway between the brain and gut is often referred to as the gut-brain axis. IS usually leads to intestinal motility disorders, dysbiosis of intestinal microbiota, and a leaky gut, which are often associated with poor prognosis in patients with IS. In recent years, several studies have suggested that intestinal inflammation and immune responses play key roles in the development of IS, and thus may become potential therapeutic targets that can drive new therapeutic strategies. However, research on gut inflammation and immune responses after stroke remains in its infancy. A better understanding of gut inflammation and immune responses after stroke may be important for developing effective therapies. This review discusses the immune-related mechanisms of the gut-brain axis after IS and compiles potential therapeutic targets to provide new ideas and strategies for the future effective treatment of IS.

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The Bridge Between Ischemic Stroke and Gut Microbes: Short-Chain Fatty Acids

Cited by 14 publications

References 185 publications

|Therapeutic and preventive effects of apigenin in cerebral ischemia: a review

|Therapeutic and preventive effects of apigenin in cerebral ischemia: a review

The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction

Gut-brain axis: Mechanisms and potential therapeutic strategies for ischemic stroke through immune functions

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