The British Society of Gastroenterology early gastric cancer/dysplasia survey: an interim report.

Dombal, F. T. de; Price, Alison; Thompson, Helen; Williams, G T; Morgan, A. G.; Softley, A; Clamp, Susan; Unwin, B J

doi:10.1136/gut.31.1.115

Cited by 57 publications

(12 citation statements)

References 9 publications

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“…Another potential cause of the higher recurrence rate in the Western hemisphere is misdiagnosis of advanced tumors as EGC [37]. The strict criteria and exhaustive histologic review used by Japanese pathologists probably eliminate these "contaminating" cases [37].…”

Section: Discussionmentioning

confidence: 99%

Early gastric cancer: Report of 58 cases

et al. 1998

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Abstract:Background. This retrospective study was carried out to review our surgical experience and to define the clinicopathologic profile of early gastric cancer in a Western country with one of the highest incidences in the world. Methods. Fifty-eight patients who had gastric surgery for early gastric cancer were included in this study. Results. The incidence of early gastric cancer was 13.9% of the patients with resected gastric cancer (58/416). The mean age of these 58 patients at diagnosis was 56.8 ؎ 12.3 years (range, 30-81 years) and the male : female ratio was 2.4 : 1. The most common presenting symptom was epigastric pain (52.4%). All patients were treated by surgical resection. Tumors were typically located in the antrum (72.4%), with a predominance of lesser curvature lesions (89.7%). Macroscopically, the majority of the lesions (63.8%) were excavated (types IIc and III). Thirty tumors were intramucosal and 28 extended into the submucosa. Thirty were of the intestinal type and 28 of the diffuse type. The rate of regional lymph node metastasis was 10.4%. The overall 5-year survival rate was 93.9%. Conclusions. The excellent response to surgical resection of early gastric cancer reported by Japanese authors is reproducible in Western countries even in the presence of regional lymph node metastasis. For this reason an aggressive surgical approach should be taken for all early gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Early gastric cancer: Report of 58 cases

et al. 1998

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“…It seems therefore reasonable to propose high-quality endoscopic follow-up for patients with low-grade dysplasia [33,37,202,206], expanding this to endoscopic resection of the most severe lesions in some patients [197,203,207]. In fact, a histological diagnosis of low-grade dysplasia in forceps biopsies, obtained from an endoscopically defined lesion, may be upgraded to a diagnosis of high-grade dysplasia or even adenocarcinoma after endoscopic mucosal resection (EMR) [208,209].…”

Section: Surveillancementioning

confidence: 99%

Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED)

et al. 2011

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Atrophic gastritis, intestinal metaplasia, and epithelial dysplasia of the stomach are common and are associated with an increased risk for gastric cancer. In the absence of guidelines, there is wide disparity in the management of patients with these premalignant conditions. The European Society of Gastrointestinal Endoscopy, the European Helicobacter Study Group, the European Society of Pathology, and the Sociedade Portuguesa de Endoscopia Digestiva have therefore combined efforts to develop evidence-based guidelines on the management of patients with precancerous conditions and lesions of the stomach. A multidisciplinary group of 63 experts from 24 countries developed these recommendations by means of repeat online voting and a meeting in June 2011 in Porto, Portugal. The recommendations emphasize the increased cancer risk in patients with gastric atrophy and metaplasia and the need for adequate staging in the case of high-grade dysplasia, and they focus on treatment and surveillance indications and methods.

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“…12 33 42 45 46 50 Grading is easier and more reproducible in a two tier than in a three tier system. These inevitably become three or five tiered systems (e.g.…”

Section: Grading Of (Adenomatous) Dysplasia and Interobserver Variabimentioning

confidence: 99%