2016
DOI: 10.3390/ijms17111849
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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

Abstract: The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by the presence of two tandem bromodomains and an extra-terminal domain. The mammalian BET family of proteins comprises BRD2, BRD3, BRD4, and BRDT, which are encoded by paralogous genes that may have been generated by repeated duplication of an ancestral gene during evolution. Bromodomains that can specifically bind acetylated lysine residues in histones serve as chromatin-targeting modules that decipher the histone acetylation… Show more

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Cited by 250 publications
(157 citation statements)
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References 135 publications
(214 reference statements)
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“…Within the BRD class of epigenetic readers is a subfamily of bromodomain and extra terminal domain (BET) proteins. These proteins are not only able to bind acetylated lysine residues, but can interact with additional transcription factors and epigenetic regulators via the extra terminal domain (Taniguchi, 2016). Of particular interest among the members of the BET protein family is bromodomain-containing 4 (Brd4) as it is linked to transcriptional initiation and super-enhancer formation (Devaiah, Gegonne, & Singer, 2016;Loven et al, 2013).…”
mentioning
confidence: 99%
“…Within the BRD class of epigenetic readers is a subfamily of bromodomain and extra terminal domain (BET) proteins. These proteins are not only able to bind acetylated lysine residues, but can interact with additional transcription factors and epigenetic regulators via the extra terminal domain (Taniguchi, 2016). Of particular interest among the members of the BET protein family is bromodomain-containing 4 (Brd4) as it is linked to transcriptional initiation and super-enhancer formation (Devaiah, Gegonne, & Singer, 2016;Loven et al, 2013).…”
mentioning
confidence: 99%
“…Since Brd4 interacts C -terminally with the RNAP II CTD, we hypothesize that the tandem bromodomains may function within transcription factories to scaffold acetylated promoters, facilitating co-regulation of transcriptionally related genes. However, this activity would be limited to Brd4 and BrdT, as Brd2 and Brd3 lack the conserved CTD through which Brd4 and BrdT interact with RNAP II (91).…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, in addition to the use of HATis and HDACis as anti-obesity and anti-diabetic agents, scientists have also begun to explore other therapeutic alternatives in the recent years. Aside from HATs and HDACs, the bromodomain and extraterminal (BET) domain family proteins (BRD2, BRD3, BRD4, and BRDT), which consists of two tandem bromodomains (BD1 and BD2) and an extra-terminal domain, are also involved in epigenetic-regulated gene transcription through interactions between the bromodomains and acetylated lysine residues on histones during cellular differentiation (136). As such, compounds which interfere with the activity of the bromodomain, and as a consequence, repress the transcriptional network, serve as attractive therapeutic agents to treat a variety of diseases, including metabolic-associated disorders.…”
Section: Bromodomain and Extra-terminal Domain Inhibitorsmentioning
confidence: 99%