2022
DOI: 10.1016/j.celrep.2022.110524
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The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes

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Cited by 15 publications
(14 citation statements)
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References 99 publications
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“…18 Embryonic stem cells lacking ZBTB11 lost clonal form and exhibited reduced proliferation. 37 All these findings support the essential role of ZBTB11 in the proliferation of normal cells. Because ZBTB11 was highly expressed in BC tissue compared with normal bladder tissue, we hypothesized that ZBTB11 may be important for BC cell proliferation and cisplatin resistance.…”
Section: Discussionsupporting
confidence: 53%
See 1 more Smart Citation
“…18 Embryonic stem cells lacking ZBTB11 lost clonal form and exhibited reduced proliferation. 37 All these findings support the essential role of ZBTB11 in the proliferation of normal cells. Because ZBTB11 was highly expressed in BC tissue compared with normal bladder tissue, we hypothesized that ZBTB11 may be important for BC cell proliferation and cisplatin resistance.…”
Section: Discussionsupporting
confidence: 53%
“…ZBTB11 gene inactivation leads to impaired mitochondrial respiratory function, resulting in proliferation arrest and cell death 18 . Embryonic stem cells lacking ZBTB11 lost clonal form and exhibited reduced proliferation 37 . All these findings support the essential role of ZBTB11 in the proliferation of normal cells.…”
Section: Discussionmentioning
confidence: 60%
“…The samples were then compared using the CRISPTimeR algorithm that identifies hits in dropout screens (Garipler et al, 2022). Depletion of multiple sgRNAs for a given gene yields a low CRISPTimeR score and identifies this gene as a positive regulator; conversely, sgRNA enrichment produces a high CRISPTimeR score corresponding to a negative regulator.…”
Section: Resultsmentioning
confidence: 99%
“…After normalization, a mixed linear model was used to evaluate gene enrichment or depletion as described (Garipler et al, 2022). Briefly, the model has the following formula: Where Counts i is the log counts of gene i ; α <[:] is the intercept for sgRNA j of gene i ; β A is the overall estimate for Time and ɛ is the error.…”
Section: Methodsmentioning
confidence: 99%
“…These ZBTB proteins can regulate the binding of p53 to the promoter of the P21CIP1 gene that encodes the CDK2 kinase inhibitor p21. Various ZBTB proteins such as PATZ1 (ZBTB19), ZBTB2, ZBTB11, ZBTB12, ZNF131 (ZBTB35) are also involved in stem cell reprogramming, either maintaining or antagonizing pluripotency [26][27][28][29][30]. This function possibly involves a collaboration with p53 which has also been implicated in this process [31].…”
Section: Zinc Finger Proteins; the Zbtb Familymentioning
confidence: 99%