This article approaches sensory modalities as semiotically active factors and organizing principles in meaning-making. The focus will be on the special case where modalities mismatch in film – i.e., the soundtrack and visuals present contradictory meanings. The conflict can be characterized by the concept of synthesis that emerges in theories of Eisenstein, Barthes, Jakobson, Lotman, and cognitivists. The artistic functions of such synthesis will be discussed with the help of examples from selected feature films. In the first place, conflicting modalities are inspected in the light of Juri Lotmanʼs theory of two incompatible, but still complementary languages that make up a mechanism for generating new information. In addition, the prospects of evaluating modality conflicts will be touched upon, dismissing synchrony and redundancy as the scale parameters, but acknowledging Lotmanʼs model of space as a primary modeling system that is capable of representing semantic conflicts.