Accordingly to Wagner, "Dwellings stand as the concrete expressions of a complex interaction among cultural skills and norms, climatic conditions and the potentialities of natural materials". This study, beginning with an enquiry into the way trans-national houses are the physical expression of interacting cultural factors, provides a theoretical framework grounded on cross-cultural studies for understanding the way cultural needs have influenced the form of the archetypal post WWII 'house on a quarter-acre block' built in Brisbane by Italian migrants.The findings reveal that while the architectural form of the Italian Trans-national houses built in Brisbane is influenced by the need to continue architectural cultural traditions in the host country, the spatial distribution of the artifact was influenced by socio-cultural factors and urban fabric, from both the native and hosting built environment, in the attempt of re-establishing and enhancing the native way of life.