Process Safety in the oil and gas industry is managed through a robust Process Safety Management (PSM) system that involves the assessment of the risks associated with a facility in all steps of its life cycle. Risk levels tend to fluctuate throughout the life cycle of many processes due to several time varying risk factors (performances of the safety barriers, equipment conditions, staff competence, incidents history, etc.). While current practices for quantitative risk assessments (e.g. Bow-tie analysis, LOPA, etc.) have brought significant improvements in the management of major hazards, they are static in nature and do not fully take into account the dynamic nature of risk and how it improves risk-based decision making In an attempt to continually enhance the risk management in process facilities, the oil and gas industry has put in very significant efforts over the last decade toward the development of process safety key performance indicators (KPI or parameters to be observed) to continuously measure or gauge the efficiency of safety management systems and reduce the risks of major incidents. This has increased the sources of information that are used to assess risks in real-time. The use of such KPIs has proved to be a major step forward in the improvement of process safety in major hazards facilities. Looking toward the future, there appears to be an opportunity to use the multiple KPIs measured at a process plant to assess the quantitative measure of risk levels at the facility on a time-variant basis.ExxonMobil Research Qatar (EMRQ) has partnered with the Mary Kay O'Connor Process Safety Center -Qatar (MKOPSC-Q) to develop a methodology that establishes a framework for a tool that monitors in real time the potential increases in risk levels as a result of pre-identified risk factors that would include the use of KPIs (leading or lagging) as observations or evidence using Bayesian Belief Networks (BN).In this context, the paper presents a case study of quantitative risk assessment of a process unit using BN. The different steps of the development of the BN are detailed, including: translation of a Bowtie into a skeletal BBN, modification of the skeletal BN to incorporate KPIs (loss of primary containment (LOPC), equipment, management and human related), and testing of the BBN with forward and backward inferences. The outcomes of the dynamic modeling of the BN with real time insertion of evidence are discussed and recommendation for the framework for a dynamic risk assessment tool are made.