The burden and epidemiology of community-acquired central nervous system infections: a multinational study

Erdem, Hakan; İnan, Asuman; Guven, Erhan; Hargreaves, Sally; Petersen, Pelle Trier; Shehata, Ghaydaa A.; Pernicova, E.; Khan, Ejaz Ahmad; Baštáková, Lenka; Namani, Sadie; Harxhi, Arjan; Roganović, Tatjana; Lakatos, Botond; Uysal, Serhat; Sıpahi, Oğuz Reşat; Crișan, Alexandru; Miftode, Egidia; Stebel, Roman; Jegorovic, Boris; Fehér, Z; Jekkel, Csilla; Pandak, Nenad; Moravveji, Alireza; Yılmaz, Hava; Khalifa, Ahmad; Muşabak, Uğur; Yılmaz, Süreyya; Jouhar, Anas; Öztoprak, Nefise; Argemi, Xavier; Baldeyrou, M.; Bellaud, G.; Moroti, Ruxandra; Hasbun, Rodrigo; Salazar, Lucrecia; Tekin, Recep; Canestri, Ana; Čalkić, Lejla; Praticò, Liliana; Yılmaz-Karadağ, Fatma; Santos, Lurdes; Pinto, A.; Kaptan, Figen; Bossi, Philippe; Aron, Joan L.; Duissenova, A.; Shopayeva, G. A.; Utaganov, B.; Grgić, Svjetlana; Ersöz, Gülden; Wu, Alan Ka-Lun; Lung, Kwok-Cheung; Bruzsa, A.; Radić, Ljiljana; Kahraman, Hasip; Momen‐Heravi, Mansooreh; Kulzhanova, Sholpan; Rigo, F.; Konkayeva, Maiya; Smagulova, Zauresh; Tang, Tian; Chan, Phillip; Ahmetagić, Sead; Porobić-Jahić, Humera; Moradi, Fatemeh; Kaya, Selçuk; Çağ, Yasemin; Bohr, Anne; Artuk, Cumhur; Çelik, İ̇lhami; Amsilli, M.; Gül, Hanefi Cem; Cascio, Antonio; Lanzafame, Massimiliano; Nassar, Mogahid

doi:10.1007/s10096-017-2973-0

Cited by 72 publications

(68 citation statements)

References 33 publications

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“…Despite limited information about the etiological spectrum of febrile encephalopathy in adults, many studies across the world have investigated the etiological spectrum of specific syndromes of CNS infections, including encephalitis syndrome in different populations [ 22 – 26 ]. A recently published large retrospective multinational study ( n = 2583) has provided information on the etiological spectrum of community acquired CNS infections from 37 referral centers in 20 countries [ 27 ]. The most frequent infecting pathogens reported in this study were Streptococcus pneumoniae and Mycobacterium tuberculosis [ 27 ], which are the same as in our study.…”

Section: Discussionmentioning

confidence: 99%

The Etiological Spectrum of Febrile Encephalopathy in Adult Patients: A Cross-Sectional Study from a Developing Country

Peidaee

Sheybani

Naderi

et al. 2018

Emergency Medicine International

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The profile of febrile encephalopathy varies based on different demographic and geographical characteristics of the study population. This retrospective, cross-sectional study was conducted to evaluate the etiological spectrum of febrile encephalopathy in hospitalized adult patients. A total of 293 patients with the mean age of 49.7 ± 23 were evaluated of whom 77.1% presented with encephalopathy syndrome. The most common diagnosis in patients with clinical syndromes suggestive of central nervous system (CNS) infection was sepsis associated encephalopathy (SAE) (22.9%), followed by bacterial meningitis (14%) and neurotuberculosis (9.9%). The comparison between the elderly and young adults showed that, in the young adults, bacterial meningitis and neurotuberculosis, and in the elderly SAE, are among the most common causes of clinical syndromes suggestive of CNS infection including febrile encephalopathy in our region. Moreover, we illustrated an upward trend for the proportion of diagnosing CNS infections among those who underwent diagnostic LP, from 40.4% in 2011 to 70% in 2015, that could be indicative of an increasing threshold for performing LP at least in our center in recent years. Whether these changes have been associated with increasing the rate of diagnostic errors or not needs to be evaluated in future studies.

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Section: Discussionmentioning

confidence: 99%

The Etiological Spectrum of Febrile Encephalopathy in Adult Patients: A Cross-Sectional Study from a Developing Country

Peidaee

Sheybani

Naderi

et al. 2018

Emergency Medicine International

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“…CNSI is still associated with severe neurological complications today. Subdural empyema, brain abscess, and hydrocephaly were among the complications reported by Pişkin et al [15] In a multicenter study by Erdem et al [31] that included 2583 patients, suppurative intracranial infection was detected in 5.6% of the patients, with most cases consisting of brain abscess (n=97), epidural abscess (n=31), and subdural empyema (n=14). In our study, brain abscess, subdural empyema, and hydrocephaly were the most common sequalae.…”

Section: Discussionmentioning

confidence: 99%

“…Demiroğlu et al [12] observed memory disorders and behavioral changes as sequelae in encephalitis patients, and neurogenic bladder and left homonymous hemianopsia in tuberculous meningitis patients. Erdem et al [31] reported the frequency of sequelae to be 18.5%, with the most common sequelae being motor deficit (5%), cranial nerve involvement (3.6%), cognitive disorder (2.7%), persistent headache (1.5%), and epilepsy (1%). Sequelae observed in our study were hemiplegia, hearing loss, and ptosis.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Patients with Central Nervous System Infection at Our Clinic: Five-year Results

Balın¹,

Tartar²,

Demirdag³

et al. 2020

mjima

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“…In a multinational study performed with 2583 patients in 37 referral centers in 20 countries to understand the burden of community-acquired central nervous system infections between 2012 and 2014 [10], staphylococci and Listeria were responsible for frequent infections in immunocompromised patients. In another study of 102 patients on maintenance hemodialysis, of 1402 patients hospitalized for infectious spondylodiscitis over a 13-year period, MRSA was the commonest pathogen found in the infectious sites followed by coagulase-negative staphylococci [11].…”

Section: Prevalence Of Staphylococci In Different Diseased Conditionmentioning

confidence: 99%

Prevalence, Diagnosis and Local Susceptibility of Staphylococci Infections

Ayeni¹

2019

Staphylococcus Aureus

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Staphylococci are normally harmless commensals occurring on the skin, mucous membrane and the general environment. However, they are increasingly implicated in different infectious states. Of particular interest is the advent of methicillin-resistant Staphylococcus aureus (MRSA) with its attendance resistance to beta lactam antibiotics. Several infectious states are now emerging with staphylococci being implicated in the infections, e.g. S. saprophyticus has been implicated in urogenital infection. It would be interesting to document the prevalence of staphylococci in different infectious state. The identification of staphylococci is supposed to be a straightforward procedure, but an alarming misidentification rate is emerging in low resource laboratories, especially in places where identification is solely by growth and fermentation on mannitol salt agar (MSA). Finally, empirical treatment of any staphylococci infection will depend on local suspectibility pattern of the strains as the susceptibilities vary from environment to environment. This chapter summarizes the current knowledge regarding the prevalence, diagnosis and local susceptibility of staphylococci in different parts of the world.

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The burden and epidemiology of community-acquired central nervous system infections: a multinational study

Cited by 72 publications

References 33 publications

The Etiological Spectrum of Febrile Encephalopathy in Adult Patients: A Cross-Sectional Study from a Developing Country

The Etiological Spectrum of Febrile Encephalopathy in Adult Patients: A Cross-Sectional Study from a Developing Country

Analysis of Patients with Central Nervous System Infection at Our Clinic: Five-year Results

Prevalence, Diagnosis and Local Susceptibility of Staphylococci Infections

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