The burden of allergic rhinitis and allergic rhinoconjunctivitis on adolescents

Blaiss, Michael S.; Hammerby, E.; Robinson, Susan; Kennedy-Martin, Tessa; Buchs, Sarah

doi:10.1016/j.anai.2018.03.028

Cited by 153 publications

(116 citation statements)

References 42 publications

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“…Allergic rhinitis (AR) is the most common immunemediated disorder as it may affect up to 40% of the paediatric population [71]. AR has clinical relevance as is frequently associated with comorbidities, including other allergies, asthma, rhinosinusitis, recurrent respiratory infections, otitis, adenoid hypertrophy (AH) and tonsillar hypertrophy (TH), as recently reported by several recent studies [72][73][74][75]. Moreover, the possible correlation between AR and AH-TH has been investigated by some studies which reported a positive association between the two disorders [76][77][78][79][80].…”

Section: Allergic Rhinitismentioning

confidence: 96%

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Varricchio¹,

Mantia

Brunese³

et al. 2020

Ital J Pediatr

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The upper airways (UA) should be considered as a functional unit. Current functional anatomy divides URT in three, mutually dependent, "junction boxes": i) the ostio-meatal complex (OMC), ii) the spheno-ethmoidal recess (SER), and iii) the rhinopharynx (RP). Correct ventilation and effective mucociliary clearance of these sites significantly affect the healthy physiology of the entire respiratory system. The OMC, SER, and RP obstruction is the first pathogenic step in the inflammatory/infectious cascade of UA disorders. The inflammation of the respiratory mucosa is the main pathogenic factor for airway obstruction. Moreover, bacterial biofilm (a strategy modality of bacterial survival) is an important local cause of systemic antibiotic ineffectiveness, recurrent infections, and antibiotic resistance. Health microbiota guarantees UA wellness; on the contrary, dysbiosis promotes and worsens UA infections. Allergy, namely type 2 inflammation, is a common cause of UA obstruction such as promoting in turn infections. Fiberoptic endoscopy is a mandatory diagnostic tool in clinical practice. Nasal cytology, mainly concerning flow cytometry, allows defining rhinitis phenotypes so allowing a precision medicine approach. Several conventional therapeutic approaches are available, but efficacy and safety should be ever properly considered before the prescription. Also, complementary medicine plays a fruitful role in the management of UA diseases. National and real-world studies are reported and discussed as they may be useful in daily clinical practice.

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Section: Allergic Rhinitismentioning

confidence: 96%

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Varricchio¹,

Mantia

Brunese³

et al. 2020

Ital J Pediatr

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“…Allergic disorders affect people of all ages and can have a substantial adverse effect on an individual's QoL and their work or educational performance 3,4,36,46,[79][80][81][82] . Bilastine is effective and well tolerated in different age groups, from school-age children through to elderly adults.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of acute urticaria in children is 1-14%, and that of persistent or chronic urticaria is 0.1-1.8% 77,78 . Allergic rhinitis and urticaria both have an adverse effect on QoL in children and adolescents, causing emotional and practical problems, limitations in daily activities and sleep problems [79][80][81][82] . Of importance in this age group, allergic rhinitis and urticaria can have a negative impact on school attendance and academic achievement 81,83,84 .…”

Section: School-age Childrenmentioning

confidence: 99%

Bilastine: a lifetime companion for the treatment of allergies

Church

Tiongco-Recto

Ridolo

et al. 2019

Current Medical Research and Opinion

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Objective: Bilastine is a potent and highly selective H 1 -antihistamine approved for the treatment of allergic rhinoconjunctivitis and urticaria. This article summarizes available data on the use of bilastine in the treatment of allergic disorders in different age groups, including younger and older adults, and school-age children and adolescents. Methods: A PubMed literature search ("bilastine") was conducted on 25 February 2019. Additional literature known to the authors and identified from the reference lists of cited publications was included. Results: Bilastine is administered orally at a dose of 20 mg once daily in adults and adolescents aged 12 years and 10 mg once daily in children aged 6 to <12 years. Clinical trials have demonstrated its efficacy at improving nasal and ocular symptoms in patients with allergic rhinitis, and wheals and itching in patients with urticaria. It has a rapid onset of action and long duration of action. Bilastine does not undergo significant metabolism and does not interact with the CYP450 system, which limits its potential for drug-drug interactions. No dosage adjustments are required in patients with renal or hepatic impairment, or in the elderly. Bilastine is generally well tolerated, even when administered at above-standard doses. It does not exhibit anticholinergic effects or cardiotoxic effects, shows no central nervous system penetration and has minimal sedative properties. It has been shown to improve health-related quality of life. Conclusions: Bilastine is a suitable option for the treatment of patients with allergic rhinoconjunctivitis or urticaria across age groups from school-age children to elderly patients.

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“…Allergic rhinitis (AR) is the most common immune-mediated disorder in childhood as it may affect up to 40% of children (1). AR is frequently associated with relevant comorbidities, including other allergies, rhinosinusitis, recurrent respiratory infections, otitis, adenoid hypertrophy (AH) and tonsillar hypertrophy (TH), as recently reported by several recent studies (2)(3)(4)(5)(6). Moreover, the possible correlation between AR and AH-TH has been investigated by some studies which reported a positive association between the two disorders (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 93%

Can an otorhinolaryngological visit induce the suspect of allergic rhinitis in children?

Ameli

Tosca

Licari

et al. 2019

Eur Ann Allergy Clin Immunol

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Allergic rhinitis (AR) is very frequent in childhood. AR is commonly associated with some co-morbidities and typical clinical features. This study aimed to test the hypothesis whether an otorhinolaryngological (ORL) visit could induce the suspect of AR. Globally, 1,002 children (550 males, mean age 5.77 years) were consecutively visited at an ORL clinic. Clinical visit, nasal endoscopy, and skin prick test were performed in all patients. In particular, history investigated atopic familiarity, birth, feeding type, passive smoking, comorbidities, including asthma, respiratory infections, otitis media, respiratory sleep disorder. Endoscopy assessed the tonsil and adenoid volume, turbinate contacts, mucosal color, and nasal discharge. Univariate and multivariate analysis were performed. The study showed that 547 (54.6%) children had AR. Some parameters were predicting factor for suspecting AR: middle turbinate contact (OR=9.27), familial atopy (OR=6.24), pale nasal mucosa (OR=4.95), large adenoid volume (OR=3.02 for score 4), and asthma co-morbidity (OR=2.95). In conclusion this real-life study showed that during an ORL visit it is possible to suspect AR in children with turbinate hypertrophy, familial atopy, nasal pale mucosa, adenoid enlargement, and asthma comorbidity.

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The burden of allergic rhinitis and allergic rhinoconjunctivitis on adolescents

Cited by 153 publications

References 42 publications

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Bilastine: a lifetime companion for the treatment of allergies

Can an otorhinolaryngological visit induce the suspect of allergic rhinitis in children?

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