The burden of chronic kidney disease in Australian patients with type 2 diabetes (the NEFRON study)

Thomas, Merlin C.; Weekes, Andrew; Broadley, Olivia J; Cooper, Mark E.; Th, Mathew

doi:10.5694/j.1326-5377.2006.tb00630.x

Cited by 3 publications

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“…The complications reduce the quality of life, increase mortality, and account for the majority of the health care costs for diabetes (3,4). Together, 30%-50% of individuals with diabetes develop DKD (5)(6)(7).…”

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confidence: 99%

Genetic and epigenetic background of diabetic kidney disease

2023

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Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD, but DKD is a complex multifactorial disease, which takes years to develop. Family studies have shown that inherited factors also contribute to the risk of the disease. During the last decade, genome-wide association studies (GWASs) have emerged as a powerful tool to identify genetic risk factors for DKD. In recent years, the GWASs have acquired larger number of participants, leading to increased statistical power to detect more genetic risk factors. In addition, whole-exome and whole-genome sequencing studies are emerging, aiming to identify rare genetic risk factors for DKD, as well as epigenome-wide association studies, investigating DNA methylation in relation to DKD. This article aims to review the identified genetic and epigenetic risk factors for DKD.

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