The Burden Of Chronic Urticaria In Europe: A Systematic Literature Review

Abstract

A61164 ±. 22 for WTP £0,0. 81±0.16 for £ 1 to 49,. 81±15 for £ 50 to 99,. 76±. 16 for £100 to 199,. 79± for £ 200 to 299,. 71±. 19 for £300 or more. Patients spent a mean of 50±134 minutes (HDSS = 2), 65±119 minutes (HDSS = 3) and 161±293 minutes (HDSS = 4) for daily management of hyperhidrosis. WTP showed the lowest correlation to disease severity. ConClusions: The current study underscores the multidimensionality of the burden of hyperhidrosis, with all aspects showing greater impairment with greater disease severity. Health utility and daily time spent in managing the condition offered significant discrimination of patients.objeCtives: To assess psoriasis patients' subjective expectations regarding their future health-related quality of life (HRQOL) and life-expectancy, and to explore variables associated with under-or overestimating behaviour. Methods: A crosssectional questionnaire survey of adult moderate to severe psoriasis patients was carried out. Patients were asked to indicate the age they expect themselves to live. HRQOL expectations were measured by the EQ-5D descriptive system for 6 months ahead and for future ages of 60,70,80 and 90, respectively. Current health state was evaluated with EQ-5D and visual analogue scale (EQ VAS), Dermatology Life Quality Index (DLQI) and Psoriasis Area and Severity Index (PASI). Results: Overall 167 patients (71% males) were included in the analysis with mean age of 50.38±12.35 years, mean EQ-5D, EQ VAS, DLQI and PASI scores were 0.71±0.30,65.3±21.08,5. 89±7.10 and 7.82±10.13, respectively. Currently 56% of the patients were on biological therapy. Patients expected 0.1±0.23 mean improvement in EQ-5D scores within 6 months (p< 0.001); inverse or palmoplantar psoriasis, and using only topical treatment or initiation of the first biological at the time of the survey were likely associated with higher expectations. Males overestimated their life-expectancy by 2.94±11.86 years whereas females underestimated by 5.23±9.34 years (p< 0.001) compared to the gender-and age-matched statistical life-expectancy. Expected mean EQ-5D scores for ages from 60 to 90 were: 0.56±0.48,0. 38±0.50,0. 15±0.55, and -0.17±0.54 (p< 0.001), respectively that are lower than the general population norms in Hungary. Both for 6 months ahead and older ages, expected EQ-5D correlated moderately with current EQ-5D and EQ VAS and only weakly with DLQI and PASI (p< 0.05). ConClusions: Patients expected considerable improvement in their HRQOL for the near future and large-scale deterioration for older ages. Exploring unrealistic expectations might help to prevent dissatisfaction with treatment benefits and to improve compliance.