The burden of depression in prostate cancer

Jayadevappa, Ravishankar; Malkowicz, S. Bruce; Chhatre, Sumedha; Johnson, Jerry; Gallo, Joseph J.

doi:10.1002/pon.2032

Cited by 128 publications

(142 citation statements)

References 57 publications

(76 reference statements)

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“…Men diagnosed with prostate cancer experience negative intrusive thoughts [28] and significant decrements in physical, mental, and social aspects of their lives, especially within the first 6 months of diagnosis [13,23]. A high incidence of depression [29,30] has been seen in patients with prostate cancer, with 12.4-17.9% of newly diagnosed (within 1 year) men actually reporting suicidal ideation [31,32]. Regardless of the precise underpinnings of this association, this trend is particularly worrisome, not least because of the relatively indolent nature of prostate cancer in general, availability of efficacious definitive treatment methods, and the physical and psychological dysfunction consequential to suicidal ideation seen in men with prostate cancer [32].…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, we observed parallel trends in suicidal and accidental death in men with prostate cancer, a novel finding of the study. Possible hypotheses to explain the link between suicide and death due to accidental injuries include mental distress [4,29], increased likelihood of physical illnesses such as cardiovascular events [5,22], and worsening of social and physical function secondary to cancer diagnosis, all of which may drive the risk of accidental death in patients with cancer. Additionally, some suicides may be misclassified as deaths of undetermined intent [17,43] or unintentional poisoning mortality [18] in registry or claims-based data, potentially inflating the incidence of accidental death.…”

Section: Discussionmentioning

confidence: 99%

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Suicide and accidental deaths among patients with non‐metastatic prostate cancer

et al. 2015

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ObjectiveTo determine if American men with prostate cancer are at increased risk of suicide/accidental death compared with other cancers and if the receipt of definitive treatment alters this association, as patients with cancer are at increased risk of suicide and evidence suggests a relationship between suicides and deaths due to accidents and externally caused injuries. Patients and MethodsDemographic, socio-economic and tumour characteristics of men with prostate cancer and men with other solid malignancies were extracted from the Surveillance, Epidemiology and End Results (SEER) database . Poisson regression models were fitted to compare the incidence of suicidal and accidental deaths in prostate cancer vs other solid cancers. Multivariate Cox regression was used to determine if receipt of definitive primary treatment impacted the risk of suicide or accidental death in men with localised/regional prostate cancer. ResultsRisk of suicidal and accidental death was significantly lower in men with prostate cancer (1 165 24-5.51, respectively, 0-3 months after diagnosis). Men with non-metastatic prostate cancer who were White, uninsured, or recommended but did not receive treatment (hazard ratio vs treated 1.44, 95% CI 1.20-1.72, and 1.44, 95% CI 1.30-1.59, both P < 0.001) were at increased risk of suicidal and accidental mortality, respectively. Absence of data about previous co-morbidities and drug addictions in the SEER dataset was an important limitation. ConclusionsRelative to other cancers, men with prostate cancer were at increased risk of suicide and accidental deaths within the first year of diagnosis and when definitive treatment was recommended but not received, suggesting the need for close monitoring and coordination with mental health professionals in at-risk men with potentially curable disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Suicide and accidental deaths among patients with non‐metastatic prostate cancer

et al. 2015

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“…Late-life major depression, cognitive impairment and disability contribute to impaired social and interpersonal functioning and increase the risk for poor medical outcomes, nursing home placement, and all-cause-mortality [3–10] . Reducing depression and disability may delay or prevent these adverse outcomes [11] .…”

Section: Introductionmentioning

confidence: 99%

Problem Adaptation Therapy for Older Adults With Major Depression and Cognitive Impairment

et al. 2015

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“…1 With regard to the types of chronic conditions, cardiometabolic conditions (diabetes and cardiovascular diseases) were the most common preexisting chronic conditions (18.1%), followed by respiratory conditions (eg, chronic obstructive pulmonary disease [COPD]) (9.8%), 1 and mental health conditions (eg, depression) (9%) among elderly men with prostate cancer. 2 A greater number of preexisting chronic conditions or higher chronic condition score can affect prostate cancer stage at diagnosis. [3][4][5][6][7][8] However, the association between preexisting chronic conditions and cancer stage at diagnosis may differ by types of chronic conditions because of the differential pathophysiological pathways of underlying diseases and prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Association between Types of Chronic Conditions and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Prostate Cancer

Raval

Madhavan

Mattes

et al. 2016

Population Health Management

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The current retrospective observational study was conducted to examine the association between types of chronic conditions and cancer stage at diagnosis among elderly Medicare beneficiaries with prostate cancer using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. The study cohort consisted of elderly men ( ‡66 years) with prostate cancer diagnosed between 2002 and 2009 (N = 103,820). Cancer stage at diagnosis (localized versus advanced) was derived using the American Joint Committee on Cancer classification. Chronic conditions were identified during the year before cancer diagnosis and classified as: (1) only cardiometabolic (CM); (2) only mental health (MH); (3) only respiratory (RESP); (4) CM + MH; (5) CM + RESP; (6) MH + RESP; (7) CM+ MH + RESP; and (8) none of the 3 types of conditions. Chi-square tests and multivariable logistic regressions were used to test the unadjusted and adjusted associations between types of chronic conditions and cancer stage at diagnosis. The highest percentage (5.8%) of advanced prostate cancer was observed among elderly men with none of the 3 types of chronic conditions (CM, RESP, MH). In the adjusted logistic regression, those with none of the 3 types of chronic conditions were 44% more likely to be diagnosed with advanced prostate cancer compared to men with all the 3 types of chronic conditions. Elderly men without any of the selected chronic conditions were more likely to be diagnosed with advanced prostate cancer; therefore, strategies to reduce the risk of advanced prostate cancer should be targeted toward elderly men without these conditions.

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The burden of depression in prostate cancer

Abstract: Depression during the treatment phase was associated with significant health resource utilization, costs and mortality among men with prostate cancer. These findings emphasize the need to effectively identify and treat depression in the setting of prostate cancer.

Cited by 128 publications

References 57 publications

Suicide and accidental deaths among patients with non‐metastatic prostate cancer

Suicide and accidental deaths among patients with non‐metastatic prostate cancer

Problem Adaptation Therapy for Older Adults With Major Depression and Cognitive Impairment

Association between Types of Chronic Conditions and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Prostate Cancer

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