The burden of end-stage osteoarthritis in Australia: a population-based study on the incidence of total knee replacement attributable to overweight/obesity

Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative

“…OA often affects large weight‐bearing joints such as the hip and knee, and its prevalence increases with higher body mass index (BMI) levels, especially among adults age >60 years (2). Obesity is a global worldwide epidemic (3), posing a great burden on OA; obese subjects have odds of 2.63 (95% confidence interval [95% CI] 2.28–3.05) of knee OA development compared to normal‐weight controls (4), and obesity has resulted in a significant increase in the incidence of total knee replacement (TKR) even in a young population (5). Since obesity is a modifiable risk factor for OA (3,6), understanding the effects of weight gain, and the potential preventive impact of weight loss on hip and knee OA is critical for the development of effective, long‐term therapeutic strategies for OA.

Weight loss (more than –5%) is associated with less knee radiographic worsening and decreases in knee pain over 4 years compared to no weight change. Weight gain (more than 5%) is associated with higher odds of medial knee joint space narrowing and knee pain development over 4 years. No significant associations were found between weight change and hip radiographic osteoarthritis (OA) or changes in hip pain. Understanding the effects of weight change on hip and knee joint degeneration may aid clinicians in developing site‐specific recommendations for noninvasive therapies for OA.

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“…OA often affects large weight-bearing joints such as the hip and knee, and its prevalence increases with higher body mass index (BMI) levels, especially among adults age >60 years (2). Obesity is a global worldwide epidemic (3), posing a great burden on OA; obese subjects have odds of 2.63 (95% confidence interval [95% CI] 2.28-3.05) of knee OA development compared to normal-weight controls (4), and obesity has resulted in a significant increase in the incidence of total knee replacement (TKR) even in a young population (5). Since obesity is a modifiable risk factor for OA (3,6), understanding the effects of weight gain, and the potential preventive impact of weight loss on hip and knee OA is critical for the development of effective, long-term therapeutic strategies for OA.…”

Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over 4 Years: Data From the Osteoarthritis Initiative

“…OA often affects large weightbearing joints such as the hip and knee, and its prevalence increases with higher levels of BMI, especially among adults over 60 years (2). Obesity is a global worldwide epidemic (3), posing a great burden on OA: obese subjects have a 2.63 (95% CI 2.28, 3.05) odds of knee OA development compared to normal-weight controls (4), and obesity has resulted in a significant increase in the incidence of TKR even in a young population (5). Since obesity is a modifiable risk factor for OA (3,6), understanding the effects of weight gain, and the potential preventive impact of weight loss on hip and knee OA is critical for the development of effective, long-term therapeutic strategies for OA.…”

Knee

“…This population-based study using data from the Australian Joint Registry originates from the joint registry group in Perth (Australia) . 4 While the Australian registry is not the largest registry, it is one of the most data-rich and, certainly for a question like this, there is access to plentiful data. The authors identified 191,723 cases of total knee arthroplasty (TKA) collected by the Australian Orthopaedic Association National Joint Registry, and the team established population normative data from the Australian Bureau of Statistics.…”