The Burden of Rhinitis and Rhinoconjunctivitis in Adolescents

Cibella, Fabio; Ferrante, Giuliana; Cuttitta, Giuseppina; Bucchieri, Salvatore; Melis, Marcello; Grutta, Stefania La; Viegi, Giovanni

doi:10.4168/aair.2015.7.1.44

Cited by 63 publications

(49 citation statements)

References 37 publications

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“…In addition, the finding of a significant improvement in ocular symptoms suggests that use of BHS as an add-on treatment could be useful in controlling the most frequent concomitant symptoms in AR children. Indeed, ocular symptoms worsen QoL, affecting daily activities in children with AR [4]. Performing nasal cytology can represent an added value, since a combined approach using both subjective and objective outcomes is advisable for a better management of children with AR.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

Malizia¹,

Fasola²,

Ferrante³

et al. 2017

Int Arch Allergy Immunol

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Background: Saline nasal irrigation is labelled as an add-on treatment in patients with allergic rhinitis (AR). The primary aim of this study was to compare the efficacy of 21-day use of buffered hypertonic saline (BHS) versus normal saline solution (NSS) on reducing nasal symptoms in children with seasonal AR (SAR). Comparing their efficacy on nasal cytology counts (NCC), quality of life, and sleep quality was the secondary aim. Methods: In this 21-day,open-label, randomized controlled study, 36 SAR children (aged 6-13 years) with a Total 5 Symptom Score (T5SS) ≥5 received twice-daily BHS or NSS delivered through a nasal douche. Efficacy measures were least square mean changes (LSmc) in T5SS, NCC, Paediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ), and Pittsburgh Sleep Quality Index (PSQI) scores. Results: BHS improved the T5SS total score to a greater extent than NSS (LSmc -6.45 vs. -5.45, p < 0.001). Concerning NCC, BHS significantly reduced the scores of neutrophils (LSmc -0.76, p = 0.004) and eosinophils (LSmc -0.46, p = 0.018), while NSS did not. Similarly, only BHS yielded a significant improvement in the PRQLQ score (LSmc -0.57, p = 0.009), whereas the improvement in PSQI score was comparable between the BHS (LSmc -0.77, p = 0.025) and NSS (LSmc -1.39, p < 0.001) groups. Overall, BHS was well tolerated. Conclusions: In children with SAR, BHS is effective in improving nasal symptoms and NCC, with an associated beneficial effect on quality of life.

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Section: Discussionmentioning

confidence: 99%

“…In Italian surveys, the prevalence ranges from 6 to 35% [2,3]. Nasal and ocular symptoms deeply affect a patient's life and activities, including their quality of life (QoL) and sleep quality (SQ) [4,5]. …”

Section: Introductionmentioning

confidence: 99%

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

Malizia¹,

Fasola²,

Ferrante³

et al. 2017

Int Arch Allergy Immunol

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“…There are wide variations in the prevalence of rhinitis and rhinoconjunctivitis in different countries and even in different regions within the same country (Cibella et al, 2015). However, compared to asthma, allergic rhinitis appears to be a transient and somewhat milder disease.…”

Section: Introductionmentioning

confidence: 99%

The impact of allergic rhinitis on quality of life: a study in western Iran

et al. 2017

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Introduction: Chronic diseases, due to their prolonged and debilitating nature, dramatically affect patient quality of life. Allergic rhinitis (AR) is one of the most common chronic diseases. The present study aimed to determine quality of life in patients with allergic rhinitis in Western Iran. Methods: In a cross-sectional study, 146 patients with AR were enrolled in this study. The required data were collected using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ). The questionnaire was distributed among the patients by a physician and analysis of data was carried out by SPSS version 16. Results: Of the total of 146 AR patients admitted to the clinic, 61% were female and 39% were male; the mean age was 29±10.17. Rhinorrhea (82.2%) was the most common symptom, and moderate to severe intermittent rhinitis (38.4%) was the most common type of the disease. A dramatic reduction in quality of life was observed in 62% of the patients, and the severity of the disease significantly reduced the quality of life (P=0.000). Conclusion: Allergic rhinitis can adversely affect every aspect of a patient's life, including sleep quality, mood and daily activities.

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“…Pathways of communication are thought to increase the likelihood of an inflammatory reaction at both sites following allergen exposure of nasal or ocular tissue [20]. AR affects the exacerbation and control of conjunctivitis, and on the opposite, the concomitant (conjunctivitis) may further impair RQoLQ [21]. …”

Section: Discussionmentioning

confidence: 99%

Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

Zhu

Xie

Guan

et al. 2016

Asia Pacific Allergy

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BackgroundThe symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine nasal provocation with health related QoL in AR are not clear.ObjectiveTo evaluate the correlations of nasal response to LTD4 and histamine nasal challenge with QoL in AR.MethodsPatients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life questionnaire (RQoLQ), and rating the symptom severity score (total symptom score 4, TSS4) in the previous week. The correlations between nasal challenge tests induced nasal responses and QoL in RQoLQ were analyzed.ResultsA total of 25 eligible AR patients enrolled and finished both LTD4 and histamine nasal challenge and completed the questionnaire of RQoLQ. Histamine nasal challenge induced sneezing, increased nasal resistant were correlated with most of the dimensions (general, practical, nasal, eye problems, and quality of sleep, p < 0.05), while LTD4 nasal challenge induced sneeze, increased nasal resistant only correlated with nasal and ocular problems. On the contrary, the severity of the sneeze assessed by TSS4, was not correlated with QoL, while the severity of rhinorrhea, congestion, and nasal pruritus were correlated with nasal and practical problems, and nasal congestion was also correlated with ocular problems (r = 0.60, p = 0.01).ConclusionLTD4 and histamine nasal challenge induced nasal responses were correlated with different clinical symptoms severity and QoL, which can be used as a good diagnosis and evaluation methods for the management of AR.

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The Burden of Rhinitis and Rhinoconjunctivitis in Adolescents

Cited by 63 publications

References 37 publications

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

The impact of allergic rhinitis on quality of life: a study in western Iran

Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

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