The burden of rotavirus-associated acute gastroenteritis in the elderly: assessment of the epidemiology in the context of universal childhood vaccination programs

Karakusevic, Anna; Devaney, Patrick; Enstone, Ashley; Kanibir, Nabi; Hartwig, Susanne; Carias, Cristina

doi:10.1080/14760584.2022.2066524

Cited by 5 publications

(3 citation statements)

References 84 publications

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“…This can be explained by the fact that older patients are at a higher risk of adverse outcomes related to acute gastroenteritis, including the one caused by rotavirus. In some studies, there was a substantial diversity in RV prevalence among older adults, where RV positivity ranged from 1% to 15% [ 2 ]. Our research confirms the importance of rotavirus as a causative agent also among older adults.…”

Section: Discussionmentioning

confidence: 99%

“…Viral gastroenteritis is one of the most common acute infectious diseases of people worldwide, and rotaviruses (RV) are the key viral pathogens responsible for severe gastroenteritis in infants and young children, but also in older adults (≥60 years) [ 1 , 2 ]. RV infections account for around 258 million cases of diarrhea in children younger than five years old, on a global level [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Detection and Molecular Characterization of Rotavirus Infections in Children and Adults with Gastroenteritis from Vojvodina, Serbia

et al. 2022

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Rotaviruses (RV) are the leading cause of gastroenteritis in infants, young children, and adults, responsible for serious disease burden. In the period 2012–2018, a cross-sectional study was conducted using stool samples collected from patients with acute gastroenteritis from Vojvodina, Serbia. We described age and gender distribution, as well as seasonal patterns of RV prevalence. Out of 1853 included stool samples, RV was detected in 29%. Hospitalized children between 1–2 years old were especially affected by RV infection (45%). The highest prevalence of infection was observed during the colder, winter/spring months. We compared sequenced representative G and P genotypes circulating in Serbia with vaccine strains and determined their genetic similarity. Genotype combination G2P[4] was the most prevalent (34.6%), followed by G2P[8] (24.1%) and G1P[8] (21.1%). Given that several epitopes were conserved, neutralization motifs among circulating strains can be characterized as sufficiently matching vaccine strains Rotarix™ and RotaTeq™, but existing antigenic disparities should not be overlooked. The present results contribute to a better insight into the prevalence of rotavirus infection in our region and point out the need for epidemiological surveillance of rotaviruses before the introduction of vaccines. These data can help formulate future vaccine strategies in Serbia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection and Molecular Characterization of Rotavirus Infections in Children and Adults with Gastroenteritis from Vojvodina, Serbia

et al. 2022

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“…This shows that rotavirus can cause severe acute gastroenteritis in children >5 years of age, and future surveillance should consider expanding the age range to study the clinical manifestations of rotaviruses in children in this age group 21 . In addition, the institutionalized elderly carry a high disease burden of rotavirus diarrhea, 22 and surveillance including both extreme age groups would allow further understanding of the virus transmission from the young to the elderly.…”

Section: Discussionmentioning

confidence: 99%

Emergence of equine‐like G3 and porcine‐like G9 rotavirus strains in Sarawak, Malaysia: 2019−2021

Tahar,

Ong,

Rahardja

et al. 2023

Journal of Medical Virology

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Rotavirus is the leading causative viral agent of pediatric acute gastroenteritis globally, infecting mostly children 5 years old and below. Data on rotavirus prevalence in Malaysia is scarce, despite the WHO's recommendation for continuous rotavirus surveillance, and has underestimated the need for national rotavirus vaccination. Characteristics of the current rotavirus strains in Malaysia have to be determined to understand the rotavirus epidemiology and vaccine compatibility. This study sought to determine the genetic relatedness of Sarawak rotavirus strains with global strains and to determine the antigenic coverage and epitope compatibility of Rotarix and RotaTeq vaccines with the Sarawak rotavirus strains via in silico analysis. A total of 89 stool samples were collected from pediatric patients (<5 years old) with acute gastroenteritis at private hospitals in Kuching, Sarawak. Rotavirus was detected using reverse transcription‐polymerase chain reaction. Positive amplicons were analyzed using nucleotide sequencing before phylogenetic analyses and assessment of epitope compatibility. Genotyping revealed G1P[8] (1/13; 7.7%), G3P[8] (3/13; 23%), G9P[4] (1/13; 7.7%), and G9P[8] (3/13; 23%), G9P[X] (1/13; 7.7%), GXP[4] (1/13; 7.7%), and GXP[8] (3/13; 23%) in samples. All wild‐type Sarawak rotavirus strains, with the exception of G1, showed variations in their phylogenetic and antigenic epitope characteristics.

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Enhanced numerical techniques for solving generalized rotavirus mathematical model via iterative method and ρ-Laplace transform

Pandey,

Nisar

2024

Partial Differential Equations in Applied Mathematics

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The burden of rotavirus-associated acute gastroenteritis in the elderly: assessment of the epidemiology in the context of universal childhood vaccination programs

Cited by 5 publications

References 84 publications

Detection and Molecular Characterization of Rotavirus Infections in Children and Adults with Gastroenteritis from Vojvodina, Serbia

Detection and Molecular Characterization of Rotavirus Infections in Children and Adults with Gastroenteritis from Vojvodina, Serbia

Emergence of equine‐like G3 and porcine‐like G9 rotavirus strains in Sarawak, Malaysia: 2019−2021

Enhanced numerical techniques for solving generalized rotavirus mathematical model via iterative method and ρ-Laplace transform

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