The C-Terminal O-S Acyl Shift Pathway under Acidic Condition to Propose Peptide-Thioesters

Kim, Bo Mi

doi:10.3390/molecules21111559

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…For example, BiVO 4 in the band structures and density of states, migration energy profile of surface reactions, band structure, and density state, electron/hole pair generation comprehensive study. Also, electron-hole pairs driven to different crystal facets [47,48]. All of these findings can obtain from comprehensive computational studies that are related to or compared with facet (011), (010) have lower absorption at 420 nm, better transport of electron-hole pair, and lower potential energy surfaces [49].…”

Section: Photocatalytic Water Splitting Modelingmentioning

confidence: 90%

New Strategy to Improve Photocatalytic Activity and Mechanistic Aspect for Water Splitting

Mittal¹

2023

Photocatalysts - New Perspectives

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Photocatalytic water splitting under irradiation of light is an ultimate system to make available renewable energy sources. However, significant efforts have been made to fabricate advanced nanocomposites; the major challenge persists, which is low efficiency and selectivity towards hydrogen evolution under the illumination of solar energy. In this chapter, the recent developments in photocatalysts, and heterojunction fabrication factors influencing the photocatalytic process for the dynamic production of hydrogen have been discussed. The improvements in photocatalyst systems have been classified as strategies to improve different factors of photocatalytic splitting such as Z-scheme systems and the influence of operating parameters such as band gap, morphology, temperature, oxygen vacancies, intensity, and pH. In addition, the thermodynamics of selective photocatalysts is conferred critically. The future research aspect of photocatalytic water splitting has been also discussed.

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Section: Photocatalytic Water Splitting Modelingmentioning

confidence: 90%

New Strategy to Improve Photocatalytic Activity and Mechanistic Aspect for Water Splitting

Mittal¹

2023

Photocatalysts - New Perspectives

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Amide‐Forming Ligation Reactions

2019

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One of the long‐standing pursuits of synthetic organic chemists is the development of chemical methods for the synthesis of peptides and proteins as tools for understanding biological processes and providing therapeutic solutions to human diseases. The advent of chemoselective ligation reactions for the chemical synthesis of peptides and proteins has enabled synthetic chemists to realize this long‐held dream. In an amide‐forming ligation reaction, two uniquely placed functional groups within the peptide allow peptide or protein segments to be joined in a chemoselective manner with an amide bond. In this chapter, some of the early methods based on principles of the capture/rearrangement strategy for ligation of peptides are catalogued, followed by some of the most versatile and well‐established contemporary methods for the preparation of linear/cyclic peptides and proteins such as the native chemical ligation (NCL) and the α‐ketoacid–hydroxylamine (KAHA) ligation. The chapter concludes with some of the most promising new generation ligation methods such as the potassium acyltrifluoroborate–hydroxylamine (KAT) ligation. The tremendous progress in the past two decades in the development of several ligation methods that rely on a pair of unique functional groups is set to expand the horizons of fully functional proteins and multi‐protein assemblies that are purely synthetically prepared. Although contemporary ligation reactions do not match the speed and efficiency at which proteins are assembled in biological systems, the repertoire of chemoselective amide‐forming ligation methods has already enabled synthetic protein chemistry to surpass biology in terms of chemical and structural diversity.

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Ynamide-Mediated Thioester Synthesis

Wang,

Zhao,

Yang

et al. 2021

J. Org. Chem.

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A novel ynamide-mediated thioester synthesis strategy was developed. Importantly, no detectable racemization was observed for the thioesterifications of carboxylic acids containing an α-chiral center, enabling it to be useful for the synthesis of peptide thioester, which is the key component of native chemical ligation. It is worth mentioning that amino acid side chain functional groups such as -OH and indole -NH are compatible with the reaction conditions, rendering their protection unnecessary. Moreover, this method was also amenable to selenoesters.

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The C-Terminal O-S Acyl Shift Pathway under Acidic Condition to Propose Peptide-Thioesters

Cited by 3 publications

References 49 publications

New Strategy to Improve Photocatalytic Activity and Mechanistic Aspect for Water Splitting

New Strategy to Improve Photocatalytic Activity and Mechanistic Aspect for Water Splitting

Amide‐Forming Ligation Reactions

Ynamide-Mediated Thioester Synthesis

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