The C6 Lyme antibody test has low sensitivity for antibody detection in cerebrospinal fluid

Vermeersch, Pieter; Resseler, Sara; Nackers, Elke; Lagrou, Katrien

doi:10.1016/j.diagmicrobio.2009.03.013

Cited by 13 publications

(11 citation statements)

References 8 publications

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“…This study is limited by its retrospective design, but this is compensated to a great extent by the large size of the study material in comparison with the previous studies of these markers in the diagnosis of LNB (12)(13)(14)(15)(16)(22)(23). The specificity of the assays may have been overestimated because only patients suspected of having LNB on clinical grounds were included in the evaluation.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there is a need for additional markers of ongoing LNB. In recent years, the B-lymphocyte attracting chemokine CXCL13 has been proposed as an early CSF marker for LNB (12)(13)(14), and the commercial C6 antibody test has also been evaluated as a marker for LNB in CSF, although with inconsistent results (15)(16).…”

Section: Lyme Borreliosis (Lb) Is the Most Common Tick-borne Infectiomentioning

confidence: 99%

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Diagnostic performance of cerebrospinal fluid chemokine CXCL13 and antibodies to the C6-peptide in Lyme neuroborreliosis

Tjernberg

Henningsson

Eliasson

et al. 2011

Journal of Infection

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Section: Discussionmentioning

confidence: 99%

Section: Lyme Borreliosis (Lb) Is the Most Common Tick-borne Infectiomentioning

confidence: 99%

Diagnostic performance of cerebrospinal fluid chemokine CXCL13 and antibodies to the C6-peptide in Lyme neuroborreliosis

Tjernberg

Henningsson

Eliasson

et al. 2011

Journal of Infection

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“…Another study used diluted and undiluted CSF with LI cut‐offs of 0.5 and 1 [16]. Retrospectively, 31 tentative cases of LNB were identified by evidence for intrathecal antibody production obtained by western blot.…”

Section: Discussionmentioning

confidence: 99%

“…The commercially available C6‐peptide ELISA has been validated only for serum samples. Data on the performance of the C6‐peptide ELISA performed on CSF for the diagnosis of LNB are limited and conflicting [14–16]. The aim of this study was to determine whether a C6‐peptide‐based ELISA can be used on CSF samples to diagnose early and late LNB patients, using a large cohort of well‐defined patients and controls.…”

Section: Introductionmentioning

confidence: 99%

High sensitivity and specificity of the C6-peptide ELISA on cerebrospinal fluid in Lyme neuroborreliosis patients

Burgel

Brandenburg²,

Gerritsen

et al. 2011

Clinical Microbiology and Infection

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Lyme neuroborreliosis (LNB) is a serious but treatable disease. The diagnosis of LNB poses a challenge to clinicians, and improved tests are needed. The C6-peptide ELISA is frequently used on serum but not on cerebrospinal fluid (CSF). Data on the sensitivity of the C6-peptide ELISA in CSF in patients suffering from LNB have been conflicting. Serum-CSF pairs from 59 LNB patients, 36 Lyme non-neuroborreliosis cases, 69 infectious meningitis/encephalitis controls and 74 neurological controls were tested in a C6-peptide ELISA. With the optimal cut-off of 1.1, the sensitivity of the C6-peptide ELISA for LNB patients in CSF was 95%, and the specificity was 83% in the Lyme non-neuroborreliosis patients, 96% in the infectious controls, and 97% in the neurological controls. These results suggest that the C6-peptide ELISA has a high sensitivity and good specificity for the diagnosis of LNB patients in CSF. The C6-peptide ELISA can be used on CSF in a clinical setting to screen for LNB.

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“…The most observable symptoms include fever, hardness of neck, flu, headache, and headache, inflammation of muscles and joints and fatigue. To nip the evil in bud is the solution of early stage symptoms [20].…”

Section: Disease Sign and Symptomsmentioning

confidence: 99%

Introduction, Sign, Symptoms, Prevention and Management of Lyme Disease Caused by <i>Borrelia burgdorferi</i> Channeled through <i>Ixodes</i> Ticks as Vector. A Review

Tabbasam¹,

Malik²,

Asghar³

et al. 2016

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God has created many miraculous creature; ticks are one of them. Borrelia burgdorferi is a bacterium that lives into the gut of ticks. When such ticks feed upon the blood of Ticks and other livestock, bacteria are transferred into their blood stream of these hosts. A disease is caused into human beings if such infected tick bites humans that are called as Lyme disease. This review will help to have a keen study on the cause, sign, symptoms, prevention and management of this disease.

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The C6 Lyme antibody test has low sensitivity for antibody detection in cerebrospinal fluid

Cited by 13 publications

References 8 publications

Diagnostic performance of cerebrospinal fluid chemokine CXCL13 and antibodies to the C6-peptide in Lyme neuroborreliosis

Diagnostic performance of cerebrospinal fluid chemokine CXCL13 and antibodies to the C6-peptide in Lyme neuroborreliosis

High sensitivity and specificity of the C6-peptide ELISA on cerebrospinal fluid in Lyme neuroborreliosis patients

Introduction, Sign, Symptoms, Prevention and Management of Lyme Disease Caused by <i>Borrelia burgdorferi</i> Channeled through <i>Ixodes</i> Ticks as Vector. A Review

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The C6 Lyme antibody test has low sensitivity for antibody detection in cerebrospinal fluid

Cited by 13 publications

References 8 publications

Diagnostic performance of cerebrospinal fluid chemokine CXCL13 and antibodies to the C6-peptide in Lyme neuroborreliosis

Diagnostic performance of cerebrospinal fluid chemokine CXCL13 and antibodies to the C6-peptide in Lyme neuroborreliosis

High sensitivity and specificity of the C6-peptide ELISA on cerebrospinal fluid in Lyme neuroborreliosis patients

Introduction, Sign, Symptoms, Prevention and Management of Lyme Disease Caused by &lt;i&gt;Borrelia burgdorferi&lt;/i&gt; Channeled through &lt;i&gt;Ixodes&lt;/i&gt; Ticks as Vector. A Review

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Introduction, Sign, Symptoms, Prevention and Management of Lyme Disease Caused by <i>Borrelia burgdorferi</i> Channeled through <i>Ixodes</i> Ticks as Vector. A Review