The cadherin–catenin complex in laryngeal squamous cell carcinoma

Galera-Ruiz, Hugo; Rios-Moreno, María José; González‐Cámpora, Ricardo; Ortega, Isicio; Fernandez, A. Moreno; García-Escudero, Antonio; Galera-Davidson, H

doi:10.1007/s00405-011-1892-4

Cited by 21 publications

(24 citation statements)

References 34 publications

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“…A significant biological difference was stressed in glottic versus supraglottic cancers. Our data evidenced an aggressive biological behavior of supraglottic cancers as reported, but we underline that a poor outcome was present in all patients with supraglottic mesenchymal‐like and mesenchymal‐close cancers. However, supraglottic epithelial tumors showed a lower aggressive profile, confirming the strongly negative prognostic role of epithelial‐to‐mesenchymal transition in supraglottic cancers.…”

Section: Discussionsupporting

confidence: 82%

“…However, innovative biomarkers that are able to define the biological behavior of the tumor are urgently needed in order to assess the risk of recurrence and tailor the patient's therapy, but they need to be validated and translated into clinical practice . It was established by several studies that epithelial‐to‐mesenchymal transition (ie, the rapid and often reversible changing from the epithelial morphology to a mesenchymal phenotype) is linked to unfavorable prognostic markers and poor prognosis in several cancers, including laryngeal SCC . During epithelial‐to‐mesenchymal transition, cancer cells lose their mechanisms of adhesion and acquire the anchorage‐independent growth ones, which lead to migration, invasion, increased metastatic potential, immunosuppression, and drug resistance .…”

Section: Introductionmentioning

confidence: 99%

“…8,9 It was established by several studies that epithelial-to-mesenchymal transition (ie, the rapid and often reversible changing from the epithelial morphology to a mesenchymal phenotype) is linked to unfavorable prognostic markers and poor prognosis in several cancers, including laryngeal SCC. 10,11 During epithelialto-mesenchymal transition, cancer cells lose their mechanisms of adhesion and acquire the anchorage-independent growth ones, which lead to migration, invasion, increased metastatic potential, immunosuppression, 12 and drug resistance. 13 The critical step during epithelial-to-mesenchymal transition is the "cadherin switch," 14 which is the decrease in the expression of E-cadherin, a transmembrane receptor, essential in the formation of intercellular junctions, 15 associated to a simultaneous increase of the expression of the transmembrane cell-cell adhesion protein N-cadherin.…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

et al. 2017

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

et al. 2017

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“…The Wnt signalling pathway is poorly understood in laryngeal cancer. Moreover, Galera-Ruiz et al suggest that the canonical Wnt pathway may be inactive in LSCC [7], though Psyrri et al determined its prognostic value in this form of cancer [31]. As knowledge of the noncanonical Wnt pathway and its role in cancer is limited, further studies are required.…”

Section: Discussionmentioning

confidence: 99%

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

Cybula

Wieteska

Józefowicz-Korczyńska

et al. 2016

CBM

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Abstract. BACKGROUND:Although the development of novel diagnostic and treatment strategies concerning laryngeal cancer is highly intensive, the survival rate remains virtually unchanged. Small non-coding RNAs appear to be very promising biomarkers -and so remain the focus of extensive investigation in laryngeal cancer. OBJECTIVE: We examined the expression of five miRNA and five genes related to cancer whether they could be potential laryngeal cancer biomarkers. METHODS:We performed an analysis in 47 patients diagnosed with laryngeal cancer. The qPCR technique was used to investigate the expression profile. RESULTS: While miR-21-3p and miR-525-5p were found to be significantly up-regulated, miR-139-3p and miR-885-5p expression is lower in laryngeal cancer. Moreover, PIK3R1 and HACE1 were found to be also down-regulated. CONCLUSIONS: The change in miRNA expression is frequent than the expression of other tested genes. The expression of passenger strands such as miR-21-3p and miR-139-3p, which are rarely investigated, is also significantly affected in laryngeal cancer. While PIK3R1, HACE1, miR-139-3p, and miR-885-5p may act as tumor suppressor genes in the studied tumour type, miR-21-3p and miR-525-5p seem to have oncogenic properties. Our findings suggest that miR-885-5p and PIK3R1 are the best indicators for the classification of laryngeal cancer tissue and normal mucosa.

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“…When it comes to cancer cases, the exact profile of β-catenin delocalization and expression level was related to tumor site and stage. Supraglottic tumors were characterized by stronger β-catenin delocalization than glottic tumors [39,40], and lip and palate tumors were not characterized by significant β-catenin dysregulation [41]. The delocalization of β-catenin was more frequently observed in poorly differentiated tumors [28,42].…”

Section: Introductionmentioning

confidence: 93%

The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

Paluszczak

2020

Cells

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The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and neck cancer, the abnormalities in several signaling pathways, which regulate cell proliferation, cell death and stemness, seem to be especially promising with regard to the development of targeted therapies. Canonical Wnt signaling is a pathway engaged in the formation of head and neck tissues, however it is not active in adult somatic mucosal cells. The aim of this review paper is to bring together significant data related to the current knowledge on the mechanisms and functional significance of the dysregulation of the Wnt/β-catenin pathway in head and neck tumors. Research evidence related to the role of Wnt signaling activation in the stimulation of cell proliferation, migration and inhibition of apoptosis in HNSCC is presented. Moreover, its role in promoting stemness traits in head and neck cancer stem-like cells is described. Evidence corroborating the hypothesis that the Wnt signaling pathway is a very promising target of novel therapeutic interventions in HNSCC is also discussed.Cells 2020, 9, 723 2 of 20 blocking the interaction between PD-1 receptor and PD-L1, may be beneficial in patients with advanced, metastatic or recurrent HNSCC [7]. However, other therapeutic options are also necessary for the better clinical management of HNSCC patients. To that end, molecular alterations observed in HNSCC need to be studied in detail, in order to point to promising drug targets. Mechanisms of Wnt/β-Catenin Pathway Activation in HNSCCRecent genomic analyses have shown the prevalence of genetic driver alterations in HNSCC, which most frequently affect genes associated with receptor tyrosine kinase (e.g., EGFR, MET, KIT), PI3K, p53, Notch or Hippo signaling pathways. On the other hand, genetic alterations in genes related to canonical Wnt signaling were rarely detected in HNSCC [8,9]. In contrast to colorectal cancers, which show molecular alterations driving Wnt signaling activation in around 90% of cases [9], HNSCC were shown to lack CTNNB1 mutations and APC mutations were present infrequently [10][11][12][13][14][15][16]. The mutations of FAT1 tumor suppressor, which encodes a protocadherin protein that binds and inactivates β-catenin, were detected in some cases of HNSCC [17]. However, the activation of the Wnt/β-catenin pathway in HNSCC seems to be more prevalent than it is suggested by genetic findings, due to cross-talk with other molecular alterations, which can lead to pathway cross-activation. Indeed, it has been shown that β-catenin can be activated via enhanced EGFR or PI3K signaling, which belong to the most frequently dysregulated signaling pathways in HNSCC. In this regard, elevated EGFR expression was associated with delocalized β-catenin expression [13]. In another study, the nuclear ...

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The cadherin–catenin complex in laryngeal squamous cell carcinoma

Cited by 21 publications

References 34 publications

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

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