The calcitonin gene-related peptide-containing fiber projection from the hypothalamus to the lateral septal area including its fine structures

Sakanaka, Masahiro; Magari, Sumiko; Emson, Piers C.; Hillyard, C. J.; Girgis, S. I.; MacIntyre, I.; Tohyama, Masaya

doi:10.1016/0006-8993(85)91210-7

Cited by 34 publications

(16 citation statements)

References 8 publications

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“…We also confirmed previous reports that a layer of the intermediate part of the lateral septal nucleus contains CGRP-ir fibers (Kawai et al, 1985;Sakanaka et al, 1985;Skofitsch and Jacobowitz, 1985b;Kruger et al, 1988a) and that CGRP terminals appear to terminate here axosomatically (Sakanaka et al, 1985). In addition, we point out for the first time that the CGRP terminal field appears to form two layers in the middle part of the lateral septum (Fig.…”

Section: Cgrp Terminal Fieldssupporting

confidence: 78%

“…CGRP-ir fibers and terminals disappeared from the main body of the lateral septal nucleus ipsilateral to unilateral perifornical lesions, but the density of CGRP-ir fibers and terminals in this area did not change following any other lesion performed in this study, indicating the existence of a hypothalamo-septal CGRP projection (Fig. 16), as has been suggested on the basis of transection experiments (Sakanaka et al, 1985). However, it has also been demonstrated by the present study that CGRP-ir fibers and terminals from the very rostral part of the lateral septum did not disappear following hypothalamic lesions and that they are of parabrachial origin (see below).…”

Section: Cgrp Projections In the Forebrainsupporting

confidence: 55%

“…Since it was originally suggested that the forebrain CGRP fibers originate in the parabrachial nuclei (Rosenfeld et al, 1983), subsequent studies have focused on the parabrachial area, and projections from the parabrachial CGRP cells to the insular cortex (Yasui et al, 1989), the bed nucleus of the stria terminalis (Shimada et al, 1985a), the central amygdaloid nucleus (Shimada et al, 1985a;Schwaber et al, 1988), and the ventromedial hypothalamic nucleus (Shimada et al, 1985a) have been described. The CGRP cells in the posterior basal thalamus have been shown to project to the caudate putamen (Inagaki et al, 1990;Kubota et al, 1991;Yasui et al, 1991) and the perirhinal cortex (Inagaki et al, 1990), whereas the CGRP cells in the perifornical/lateral hypothalamus may give rise to CGRP fibers in the lateral septum (Sakanaka et al, 1985). Despite the fairly detailed information provided by these studies, certain gaps remain in our knowledge of the topography of CGRP in the forebrain.…”

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confidence: 92%

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Calcitonin gene-related peptide-containing pathways in the rat forebrain

et al. 2005

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The present study focuses on the topographical distribution of calcitonin gene-related peptide (CGRP)-containing cell bodies and fibers and their connections and pathways in the rat forebrain. We confirm previously reported CGRP projections from the perifornical area of the hypothalamus to the lateral septum, from the posterior thalamus to the caudate putamen and cerebral cortex, and from the parabrachial nuclei to the central extended amygdala, lateral hypothalamus, and ventromedial thalamus. Despite previous descriptions of CGRP in the central nervous system, important neuroanatomical aspects of the forebrain CGRP system remained obscure, which we addressed by using brain lesion techniques combined with modern immunohistology. We first report CGRP terminal fields in the olfactory-anterior septal region and also CGRP projections from the parabrachial nuclei to the olfactory-anterior septal region, the medial prefrontal cortex, the interstitial nucleus of the anterior commissure, the nucleus of the lateral olfactory tract, the anterior amygdaloid area, the posterolateral cortical amygdaloid nucleus, and the dorsolateral part of the lateral amygdaloid nucleus. In addition, we identified a CGRP cell group in the premamillary nuclei and showed that it projects to the medial CGRP layer of the lateral septum. CGRP fibers usually join other pathways rather than forming bundles. They run along the fornix from the hypothalamus, along the supraoptic decussations or the inferior thalamic peduncle-stria terminalis pathway from the posterior thalamus, and along the superior cerebellar peduncle, thalamic fasciculus, and ansa peduncularis from the parabrachial nuclei. This description of the forebrain CGRP system will facilitate investigation of its role in higher brain functions.

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Section: Cgrp Terminal Fieldssupporting

confidence: 78%

Section: Cgrp Projections In the Forebrainsupporting

confidence: 55%

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confidence: 92%

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Calcitonin gene-related peptide-containing pathways in the rat forebrain

et al. 2005

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“…First a projection arising from the lateral hypothalamus and terminating in the lateral septum in the form of perisomatic baskets (Sakanaka et al, 1985). Similar CGRPi perisomatic baskets were found in the septum of birds in the current study and in reptiles (our unpublished observations).…”

Section: Cgrp and The Comparative Neuroanatomy Of The Avian Telencephsupporting

confidence: 65%

Distribution of CGRP-like immunoreactivity in the chick and quail brain

et al. 2000

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“…CGRP-immunoreactive fibres of the forebrain and diencephalon have been found to be derived from the parabrachial area Shimada, Shiosaka, Emson, Hillyard, Girgis, MacIntyre & Tohyama, 1985b) and from a plexus on the ventral surface of the hypothalamus (Sakanaka et al 1985). Two projections have been found to originate from the former site: one derives from its dorsolateral part and projects to the ventromedial nucleus of the thalamus (mid-brain) (termed 'lateral' projection) and the other originates from its ventral portion and projects to the red nucleus of the striae terminalis, central amygdaloid nucleus (forebrain) and far-lateral hypothalamus (mid-brain) (termed 'ventral' projection) (Shimada et al 1985 b).…”

Section: Localizationmentioning

confidence: 99%

Biology of Peptides From the Calcitonin Genes

1987

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Despite being products from the same gene, there is clearly a marked divergence in the distribution and physiological role of calcitonin and CGRP. Whereas calcitonin is predominantly distributed in the thyroid, CGRP is abundant in the nervous system throughout the body. Though the peptides have only weak structural homologies, a generally similar conformation enables them to interact at each other's receptors. Hence the pharmacological effects of the peptides faintly resemble one another. Calcitonin receptors are mainly found on osteoclasts and at certain sites in the nervous system. CGRP binding sites are abundant in the cerebellum and blood vessels. Calcitonin is a circulating hormone controlling osteoclastic activity. CGRP acts as a neurotransmitter or neuromodulator centrally, and released from perivascular nerve terminals, it modulates arteriolar tone. Released from motoneurones, CGRP may also play a trophic role regulating the muscle acetylcholine receptor state. The next decade should establish the physiological role of CGRP and the regulation of the expression of the calcitonin/CGRP gene complex.

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The calcitonin gene-related peptide-containing fiber projection from the hypothalamus to the lateral septal area including its fine structures

Cited by 34 publications

References 8 publications

Calcitonin gene-related peptide-containing pathways in the rat forebrain

Calcitonin gene-related peptide-containing pathways in the rat forebrain

Distribution of CGRP-like immunoreactivity in the chick and quail brain

Biology of Peptides From the Calcitonin Genes

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