The Calcium Sensor CBL2 and Its Interacting Kinase CIPK6 Are Involved in Plant Sugar Homeostasis via Interacting with Tonoplast Sugar Transporter TST2

Deng, Jinwu; Yang, Xiyan; Sun, Weinan; Miao, Yuhuan; He, Liangrong; Zhang, Xianlong

doi:10.1104/pp.19.01368

Cited by 49 publications

(38 citation statements)

References 58 publications

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“…In salt stress, MdCIPK13 was required for the phosphorylation of MdSUT2.2 protein, which enhanced its stability as well as transport activity (Ma et al, 2019). In cotton ( Gossypium hirsutum ), CBL2‐CIPK6‐TONOPLAST SUGAR TRANSPORTER2 (TST2) signaling cascade regulates glucose homeostasis (Deng et al, 2020). Cotton CBL2 recruits CIPK6 to the tonoplast and interacts with the tonoplast‐localized sugar transporter GhTST2 resulting in sugar accumulation and abiotic stress tolerance in plants (Deng et al, 2020).…”

Section: The Interplay Between Sugars and Phytohormones Under Abioticmentioning

confidence: 99%

Plant sugars: Homeostasis and transport under abiotic stress in plants

Saddhe

Manuka

Suprasanna

2020

Physiologia Plantarum

212

105

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The sessile nature of plants' life is endowed with a highly evolved defense system to adapt and survive under environmental extremes. To combat such stresses, plants have developed complex and well‐coordinated molecular and metabolic networks encompassing genes, metabolites, and acclimation responses. These modulate growth, photosynthesis, osmotic maintenance, and carbohydrate homeostasis. Under a given stress condition, sugars act as key players in stress perception, signaling, and are a regulatory hub for stress‐mediated gene expression ensuring responses of osmotic adjustment, scavenging of reactive oxygen species, and maintaining the cellular energy status through carbon partitioning. Several sugar transporters are known to regulate carbohydrate partitioning and key signal transduction steps involved in the perception of biotic and abiotic stresses. Sugar transporters such as SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTER (SWEETs), SUCROSE TRANSPORTERS (SUTs), and MONOSACCHARIDE TRANSPORTERS (MSTs) are involved in sugar loading and unloading as well as long‐distance transport (source to sink) besides orchestrating oxidative and osmotic stress tolerance. It is thus necessary to understand the structure–function relationship of these sugar transporters to fine‐tune the abiotic stress‐modulated responses. Advances in genomics have unraveled many sugars signaling components playing a key role in cross‐talk in abiotic stress pathways. An integrated omics approach may aid in the identification and characterization of sugar transporters that could become targets for developing stress tolerance plants to mitigate climate change effects and improve crop yield. In this review, we have presented an up‐to‐date analysis of the sugar homeostasis under abiotic stresses as well as describe the structure and functions of sugar transporters under abiotic stresses.

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Section: The Interplay Between Sugars and Phytohormones Under Abioticmentioning

confidence: 99%

Plant sugars: Homeostasis and transport under abiotic stress in plants

Saddhe

Manuka

Suprasanna

2020

Physiologia Plantarum

212

105

View full text Add to dashboard Cite

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“…In addition, AKINβ1, an important gene in sugar signaling, interacts with AtCBL1, suggesting that AtCBL1 has a novel function in the regulation of glucose and gibberellin signals [127]. Recently, cotton (Gossypium hirsutum) GhCBL2 has been shown to recruit GhCIPK6 to the tonoplast and interact with TST2 (tonoplast-localized sugar transporter 2) to regulate sugar homeostasis [109]. Thus, uncovering the downstream components of CBL-CIPK signaling may help to expand in the current understanding of plant growth and development.…”

Section: The Role Of Cbl-cipk Network In Plant Developmentmentioning

confidence: 99%

The CBL–CIPK Pathway in Plant Response to Stress Signals

et al. 2020

IJMS

107

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Plants need to cope with multitudes of stimuli throughout their lifecycles in their complex environments. Calcium acts as a ubiquitous secondary messenger in response to numerous stresses and developmental processes in plants. The major Ca2+ sensors, calcineurin B-like proteins (CBLs), interact with CBL-interacting protein kinases (CIPKs) to form a CBL–CIPK signaling network, which functions as a key component in the regulation of multiple stimuli or signals in plants. In this review, we describe the conserved structure of CBLs and CIPKs, characterize the features of classification and localization, draw conclusions about the currently known mechanisms, with a focus on novel findings in response to multiple stresses, and summarize the physiological functions of the CBL–CIPK network. Moreover, based on the gradually clarified mechanisms of the CBL–CIPK complex, we discuss the present limitations and potential prospects for future research. These aspects may provide a deeper understanding and functional characterization of the CBL–CIPK pathway and other signaling pathways under different stresses, which could promote crop yield improvement via biotechnological intervention.

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“…Ectopic expression of receptor-like kinases (RLKs) improved cotton tolerance and resistance to fungal pathogen infections [ 62 , 63 , 64 , 65 , 66 ]. Calcineurin B-like protein and CBL-interacting protein kinases (CIPKs) were proved to be associated with cotton oil and sugar content and stress responses [ 59 , 67 , 68 , 69 , 70 ]. Glycosyltransferases (UGT) were identified to participate and function in biosynthesis process of hemicellulose glucuronoxylan xylan during fiber and plant development whereas xyloglucan endo-transglycosylases /hydrolases (XTH) would limit the elongation of cotton fiber [ 56 , 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Weighted Gene Co-Expression Network Analysis Reveals Hub Genes Contributing to Fuzz Development in Gossypium arboreum

Shang

Cheng

et al. 2021

Genes

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Fuzzless mutants are ideal materials to decipher the regulatory network and mechanism underlying fuzz initiation and formation. In this study, we utilized two Gossypium arboreum accessions differing in fuzz characteristics to explore expression pattern differences and discriminate genes involved in fuzz development using RNA sequencing. Gene ontology (GO) analysis was conducted and found that DEGs were mainly enriched in the regulation of transcription, metabolic processes and oxidation–reduction-related processes. Weighted gene co-expression network analysis discerned the MEmagenta module highly associated with a fuzz/fuzzless trait, which included a total of 50 hub genes differentially expressed between two materials. GaFZ, which negatively regulates trichome and fuzz formation, was found involved in MEmagenta cluster1. In addition, twenty-eight hub genes in MEmagenta cluster1 were significantly up-regulated and expressed in fuzzless mutant DPL972. It is noteworthy that Ga04G1219 and Ga04G1240, which, respectively, encode Fasciclin-like arabinogalactan protein 18(FLA18) and transport protein, showed remarkable differences of expression level and implied that they may be involved in protein glycosylation to regulate fuzz formation and development. This module and hub genes identified in this study will provide new insights on fiber and fuzz formation and be useful for the molecular design breeding of cotton genetic improvement.

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The Calcium Sensor CBL2 and Its Interacting Kinase CIPK6 Are Involved in Plant Sugar Homeostasis via Interacting with Tonoplast Sugar Transporter TST2

Cited by 49 publications

References 58 publications

Plant sugars: Homeostasis and transport under abiotic stress in plants

Plant sugars: Homeostasis and transport under abiotic stress in plants

The CBL–CIPK Pathway in Plant Response to Stress Signals

Weighted Gene Co-Expression Network Analysis Reveals Hub Genes Contributing to Fuzz Development in Gossypium arboreum

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