The Cameroon Mobile Phone SMS (CAMPS) Trial: A Randomized Trial of Text Messaging versus Usual Care for Adherence to Antiretroviral Therapy

Mbuagbaw, Lawrence; Thabane, Lehana; Ongolo‐Zogo, Pierre; Lester, Richard; Mills, Edward J.; Śmieja, Marek; Dolovich, Lisa; Kouanfack, Charles

doi:10.1371/journal.pone.0046909

Cited by 217 publications

(366 citation statements)

References 23 publications

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“…Our results are similar to those found by Mbuagbaw et al (2012), who found no impact of weekly motivational SMS reminders on adherence to ART in Cameroon. Similarly, Shet et al (2014) found no impact of an automated interactive telephone reminder system on adherence to ART in India, a socioeconomic context that is similar to Pakistan.…”

Section: Discussionsupporting

confidence: 91%

“…Two early trials found an impact of short-message service (SMS)-based interventions on drug adherence to ART for people living with HIV (Lester et al 2010;Pop-Eleches et al 2011) and, based on these findings, a Cochrane systematic review was published, advocating their use (Horvath et al 2012). However, more recent trials using motivational weekly SMS reminders in Cameroon and daily automated voice calls in India, found no impact of these interventions on drug adherence to ART (Mbuagbaw et al 2012;Shet et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Impact of mobile message reminders on tuberculosis treatment outcomes in Pakistan

Mohammed¹,

Glennerster²,

Khan³

2016

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The International Initiative for Impact Evaluation (3ie) is an international grant-making NGO promoting evidence-informed development policies and programmes. We are the global leader in funding, producing and synthesising high-quality evidence of what works, how, why and at what cost. We believe that better and policy-relevant evidence will make development more effective and improve people's lives. 3ie impact evaluations3ie-supported impact evaluations assess the difference a development intervention has made to social and economic outcomes. 3ie is committed to funding rigorous evaluations that include a theory-based design, use the most appropriate mix of methods to capture outcomes and are useful in complex development contexts. About this report3ie accepted the final version of this report, Impact of mobile message reminders on tuberculosis treatment outcomes in Pakistan, as partial fulfilment of requirements under grant OW1.48 issued under Open Window 1. The content has been copy-edited and formatted for publication by 3ie. All of the content is the sole responsibility of the authors and does not represent the opinions of 3ie, its donors or its board of commissioners. Any errors and omissions are the sole responsibility of the authors. Any comments or queries should be directed to the corresponding author, Shama Mohammed at shama@post.harvard.edu SummaryTuberculosis (TB) is the second leading cause of death from infectious disease globally. The treatment is long and results in side effects. Adherence to TB treatment regimens is essential for TB control, as failure to adhere can result in multi-drug-resistant TB. Mobile health offers the opportunity for remote delivery of health. We conducted a randomized controlled trial to gauge the impact of daily two-way SMS reminders on the treatment outcomes of people with drug-susceptible TB in Karachi, Pakistan.We enrolled 2,207 people with drug-susceptible TB into the trial. Once enrolled, mobile phone-based randomization was used to allocate them to either the Zindagi SMS system or a control group that received the standard of care offered by the treating clinic.The Zindagi SMS system was designed to increase adherence to TB treatment. The system is a two-way SMS reminder system in which patients were sent daily SMS messages and were asked to respond via SMS or a missed (unbilled) call to indicate that they had taken their medication. Patients who did not respond for seven days in a row were followed up over the phone. Over the study period, participants who were on the Zindagi SMS system throughout their treatment had a mean response rate of 29 per cent. Response rates started at 48 per cent in the first two weeks in the study and fell to 24 per cent (for participants in the eight month treatment regimen) or 20 per cent (for participants in the six-month treatment regimen). Eighty-five per cent of participants on the Zindagi SMS system responded to the system at least once.The study found no difference in treatment success rate between the Zindagi SMS and contro...

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Impact of mobile message reminders on tuberculosis treatment outcomes in Pakistan

Mohammed¹,

Glennerster²,

Khan³

2016

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“…The study concluded that phone text messages did not significantly improve adherence to ART in this study. Other types of messaging or longer term studies were recommended [27].…”

Section: Resultsmentioning

confidence: 99%

Does Message-Based Communication Through Mobile Phones for Medication and Treatment Adherence Improve Health Outcomes? A Systematic Review

Mwangi¹,

Mukanya²

2017

J Pharma Care Health Sys

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Medical non-adherence has been a pervasive issue in healthcare for far too long and consequences of medical non-adherence are far reaching. With the proliferation of mobile technology globally, there have been concerted efforts to improve adherence using mHealth both in developed and developing countries. The objective of this study was to evaluate through previous studies whether mobile phone innovations improve health outcomes through adherence messages to patients and how many of the studies mention and actually consider the content going out to patients as contributing to positive or negative health outcome. A systematic review was conducted using four search engines: PubMed, Mendley, Advanced Google, and Google Scholar. The publications were randomized clinical trials, cross-sectional studies, and pre and post interventional studies. The publications reviewed were considered to be eligible if they were based on use of mobile technology or smart phone applications in improving health outcomes through sending adherence messages. Forty one potential articles were retrieved based on the first search criteria and review of abstracts. Full text was not obtainable for 11 articles due to fees to access the document and/or a registration requirement for the websites making the full text inaccessible. Nine articles were published before the year 2009, 7 were systematic reviews, 1 was an SMS based study but was used by community health workers and did not necessarily address adherence, 3 were protocols for a study to be done, 10 articles met all the inclusion criteria. Mobile health technology has been proven to contribute towards improving adherence to treatment, medication and appointments. However it is crucial to consider the content and its development processes just as much as the technology in use as this might elevate the health outcomes even higher.

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“…One example of a study employing RCTs to examine the efficacy of mHealth include Watts et al, (2013) who conducted a RCT comparing the delivery modality (mobile phone/tablet or fixed computer) of a cognitive behavioural therapy intervention for the treatment of depression. Other examples based in developing countries can be found in the work of Chang et al, (2011), Hoffman et al, (2010, Jones et al,(2012), Lester et al,(2010); Mbuagbaw et al,(2012), Pop-Eleches et al, (2011), & Zurovac et al, (2011. …”

Section: Factorialmentioning

confidence: 99%

Predicting Participant Consent in mHealth Trials – A Caregiver’s Perspective

O’Connor

Heavin

Gallagher

et al. 2017

AJIS

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Informed consent is sought prior to conducting a healthcare intervention on a person. When a healthcare intervention involves a young child, their caregiver is required to provide informed consent on their behalf. However, little is known on the behavioural intentions of participants to provide consent when a mobile health (mHealth) intervention is involved in a clinical trial scenario. Understanding this phenomenon is important, without consent appropriate data may not be collected to empirically examine the implications of mHealth initiatives when delivering healthcare services to children in a 'real world context'. The objective of this paper is to explore the behavioural intentions of caregivers to provide consent for children (under five years of age) to participate in mHealth Randomised Control Trials (RCT) in developing countries and subsequently develop a predictive model for consent giving. Data was captured vis-à-vis interviews with Malawian caregivers in Africa. The findings reveal that emotional response stimuli play a major role during the participant informed consent process resulting in the involvement (or not) of a child within an RCT. The study contributes to, and opens up, avenues for critical research on the role of informed consent as part of RCT-related projects, especially concerning the involvement of children. This new knowledge may be leveraged to address participant uncertainties and subsequently improve the rate of paediatric recruitment in mHealth trial scenarios.

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The Cameroon Mobile Phone SMS (CAMPS) Trial: A Randomized Trial of Text Messaging versus Usual Care for Adherence to Antiretroviral Therapy

Cited by 217 publications

References 23 publications

Impact of mobile message reminders on tuberculosis treatment outcomes in Pakistan

Impact of mobile message reminders on tuberculosis treatment outcomes in Pakistan

Does Message-Based Communication Through Mobile Phones for Medication and Treatment Adherence Improve Health Outcomes? A Systematic Review

Predicting Participant Consent in mHealth Trials – A Caregiver’s Perspective

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