The Canadian Hypoglycemia Assessment Tool Program: Insights Into Rates and Implications of Hypoglycemia From an Observational Study

Aronson, Ronnie; Goldenberg, Ronald; Boras, Damir; Skovgaard, Rasmus; Bajaj, Harpreet S.

doi:10.1016/j.jcjd.2017.01.007

Cited by 32 publications

(37 citation statements)

References 21 publications

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“… 19 Not surprisingly, in contrast with other Canadian-based observational investigations of hypoglycemia epidemiology, the results of this study are relatively more comparable, with main differences likely attributable to variations in hypoglycemia measurement (ie, scope, definitions, and data collection) or sampling frame/methodology. For example, the Canadian cohort of the Hypoglycemia Assessment Tool program 41 assessed severe hypoglycemia 6 months retrospectively and 4 weeks prospectively. These data collection periods may not have been sufficiently sensitive to capture severe hypoglycemia (a rare event), potentially resulting in an underestimation of annualized incidence densities.…”

Section: Discussionmentioning

confidence: 99%

Real-world crude incidence of hypoglycemia in adults with diabetes: Results of the InHypo-DM Study, Canada

Ratzki‐Leewing

Harris

Mequanint

et al. 2018

BMJ Open Diab Res Care

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ObjectiveVery few real-world studies have been conducted to assess the incidence of diabetes-related hypoglycemia. Moreover, there is a paucity of studies that have investigated hypoglycemia among people taking secretagogues as a monotherapy or in combination with insulin. Accordingly, our research team developed and validated the InHypo-DM Person with Diabetes Mellitus Questionnaire (InHypo-DMPQ) with the aim of capturing the real-world incidence of self-reported, symptomatic hypoglycemia. The questionnaire was administered online to a national sample of Canadians (≥18 years old) with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) treated with insulin and/or insulin secretagogues.Research design and methodsSelf-report data obtained from the InHypo-DMPQ were descriptively analyzed to ascertain the crude incidence proportions and annualized incidence densities (rates) of 30-day retrospective non-severe and 1-year retrospective severe hypoglycemia, including daytime and nocturnal events.ResultsA total of 552 people (T2DM: 83%; T1DM: 17%) completed the questionnaire. Over half (65.2%) of the total respondents reported experiencing at least one event (non-severe or severe) at an annualized crude incidence density of 35.1 events per person-year. The incidence proportion and rate of non-severe events were higher among people with T1DM versus T2DM (77% and 55.7 events per person-year vs 54% and 28.0 events per person-year). Severe hypoglycemia was reported by 41.8% of all respondents, at an average rate of 2.5 events per person-year.ConclusionsThe results of the InHypo-DMPQ, the largest real-world investigation of hypoglycemia epidemiology in Canada, suggest that the incidence of hypoglycemia among adults with diabetes taking insulin and/or insulin secretagogues is higher than previously thought.

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Section: Discussionmentioning

confidence: 99%

Real-world crude incidence of hypoglycemia in adults with diabetes: Results of the InHypo-DM Study, Canada

Ratzki‐Leewing

Harris

Mequanint

et al. 2018

BMJ Open Diab Res Care

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“…Identification of those who will benefit from education is key to enhancing patient well‐being and reduce carer and healthcare system burden. There are limited data regarding patient knowledge and behaviour related to NH prevention and care …”

Section: Introductionmentioning

confidence: 99%

“…There are limited data regarding patient knowledge and behaviour related to NH prevention and care. 12 We developed a questionnaire for T1D adults to assess glucose self-management, particularly related to overnight BG. We believe this is the first such Australian study.…”

Section: Introductionmentioning

confidence: 99%

Suboptimal behaviour and knowledge regarding overnight glycaemia in adults with type 1 diabetes is common

Larsson

Januszewski

McGrath

et al. 2018

Internal Medicine Journal

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“…Hypoglycemia experiences could influence the person's behaviors used in self-management to include more frequent self-monitoring of blood glucose, more contact with health care provider and to reduce attendance in the workplace. In addition, FoH could also lead to dysfunctional self-care behaviors including reduction in or skipping of insulin doses, excess calorie intake and avoidance of physical activity [8].…”

Section: Introductionmentioning

confidence: 99%

Beliefs and Experiences of Fear of Hypoglycemia and Use of Uncooked Cornstarch before Bedtime in Persons with Type 1-Diabetes

Anderbro¹,

Moberg²,

Adamson³

et al. 2018

OJN

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Introduction: Among persons living with type 1-diabetes hypoglycemia and fear of hypoglycemia remain limiting barriers for achieving optimal glucose control and a good quality of life. Fear of hypoglycemia has been found stable over time if not treated. Uncooked cornstarch has been found to reduce the risk of hypoglycemia but has not been studied in relation to fear of hypoglycemia. The aims of this study were to through clinical data, self-reported measures and clinical interviews explore subjects' experience of using uncooked cornstarch before bedtime and their beliefs and experiences of fear of hypoglycemia. Methods: Mixed methods with both quantitative and qualitative data were used. Self-reported measures of hypoglycemia and fear of hypoglycemia were compared to subjects' responses during a clinical interview. The interviews were analyzed with a functional behavior analytical approach. Results: A total of five subjects took part in the study. One subject perceived the uncooked cornstarch helpful in reducing hypoglycemia. Several subjects could recall frightening hypoglycemic episodes triggering their fear. Three out of the five subjects reported avoidance behaviors such as excessive self-monitoring of blood glucose or overeating related to fear of hypoglycemia. Conclusions: The uncooked cornstarch was found appetizing but was not perceived as having an effect on BG or hypoglycemia frequency. The clinical interviews confirmed previous research regarding experience of hypoglycemia and fear of hypoglycemia.

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The Canadian Hypoglycemia Assessment Tool Program: Insights Into Rates and Implications of Hypoglycemia From an Observational Study

Cited by 32 publications

References 21 publications

Real-world crude incidence of hypoglycemia in adults with diabetes: Results of the InHypo-DM Study, Canada

Real-world crude incidence of hypoglycemia in adults with diabetes: Results of the InHypo-DM Study, Canada

Suboptimal behaviour and knowledge regarding overnight glycaemia in adults with type 1 diabetes is common

Beliefs and Experiences of Fear of Hypoglycemia and Use of Uncooked Cornstarch before Bedtime in Persons with Type 1-Diabetes

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