The Canine Transmissible Venereal Tumor: a Unique Result of Tumor Progression

Cohen, Dan

doi:10.1016/s0065-230x(08)60943-4

Cited by 131 publications

(188 citation statements)

References 98 publications

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Section: Ctvtmentioning

confidence: 99%

“…Spread by the physical transfer of cancer cells during coitus, CTVT is characterized by the appearance of lesions around the external genitalia that can affect both sexes of any breed of dog (Karlson and Mann, 1952;Brown et al, 1980;Cohen, 1985). The disease has a global distribution and has been documented in six continents (Cohen, 1985;Das and Das, 2000). CTVT and its transmissible phenotype were first documented in 1876 by Nowinsky (Nowinsky, 1876), and the tumor subsequently became a popular model for cancer biologists (Cohen, 1985; Das and Das, 2000).…”

Section: Ctvtmentioning

confidence: 99%

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Clonally transmissible cancers in dogs and Tasmanian devils

2008

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Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are the only known naturally occurring clonally transmissible cancers. These cancers are transmitted by the physical transfer of viable tumor cells that can be transplanted across histocompatibility barriers into unrelated hosts. Despite their common etiology, DFTD and CTVT have evolved independently and have unique life histories and host adaptations. DFTD is a recently emerged aggressive facial tumor that is threatening the Tasmanian devil with extinction. CTVT is a sexually transmitted tumor of dogs that has a worldwide distribution and that probably arose thousands of years ago. By contrasting the biology, molecular genetics and immunology of these two unusual cancers, I highlight the common and unique features of clonally transmissible cancers, and discuss the implications of clonally transmissible cancers for host-pathogen evolution.

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Section: Ctvtmentioning

confidence: 99%

Section: Ctvtmentioning

confidence: 99%

Clonally transmissible cancers in dogs and Tasmanian devils

2008

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“…Inicialmente esta hipótese se originou a partir de três linhas de observação. Na primeira linha, Cohen (1985) demonstrou que este tumor só podia ser transmitido por células vivas, principalmente pelo coito e experimentalmente, pela inoculação de células tumorais vivas em cães alogênicos imunocompetentes. O estudo excluiu, portanto, células mortas ou filtradas celulares.…”

Section: Transmissibilidade Do Tumor Venéreo Transmissível Canino (Tvtc)unclassified

Canine transmissible venereal tumor. The oldest clonal lineage known in nature

Regiani¹,

Vasconcellos²

2018

Pubvet

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RESUMO A técnica de sequenciamento gênico, utilizada no estudo da origem clonal do tumor venéreo transmissível canino (TVTC), abriu novas possibilidades de sondar vulnerabilidades genéticas do câncer, e relações hospedeiro-tumor. De modo análogo, à evolução darwiniana, as células tumorais com maior potencial adaptativo apresentam uma vantagem seletiva em relação às células menos aptas. Desse modo, o câncer transmissível de ocorrência natural, representa um modelo ideal para a investigação evolutiva entre as células cancerosas em seu microambiente tumoral, e o macroambiente circundante. Com objetivo de discutir o impacto das recentes descobertas neste campo, realizou-se uma análise das publicações indexadas na base de dados PubMed ® (Instituto Nacional de Saúde Americano, National Institutes of Health), utilizando os descritores na língua inglesa: canine transmissible venereal tumor, canine transmissible venereal, canine transmissible. Estudos genômicos demonstraram que a linhagem clonal do TVTC é a mais antiga linhagem tumoral conhecida (cerca de 11.000 anos), sendo transmissível por transferência alogênica. Aspectos singulares como evasão ao sistema imune do hospedeiro, também foram revisados. Palavras chave: cães, câncer, epidemiologia Canine transmissible venereal tumor. The oldest clonal lineage known in natureABSTRACT The gene sequencing technique, used in the study of the clonal origin of canine venereal transmissible tumor (CTVT), opened up new possibilities of probing genetic vulnerabilities of cancer, and host-tumor relations. Analogous to Darwinian evolution, tumor cells with higher adaptive potential present a selective advantage over less apt cells, and thus, naturally occurring transmissible cancer, represents an ideal model for the evolutionary investigation between cancer cells in their Microenvironment, and the surrounding macroenvironment. In order to discuss the impact of the recent findings in this field, an analysis of publications indexed in the PubMed ® database (National Institutes of Health) using the English descriptors: venereal canine transmissible Tumor, transmissible venereal canine, transmissible canine. Genomic studies have shown that the clonal lineage of the CTVT is the oldest known tumor line (about 11,000 years old), and can be transmitted by allogeneic transfer. Unique aspects such as evasion to the host immune system were also reviewed.

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“…Astonishingly, canine sarcoma spread from one dog to another as venereal disease. 111,112 Not sarcoma virus nor cellular DNA but sarcoma cells themselves. Once sarcoma cells spread to a new dog, the tumor grows progressively for about 4-6 months and then regresses; lethal metastasis occurs in puppies and immunosuppressed dogs.…”

Section: Molecular Theory: From Molecules To Pathways To Cells To Tismentioning

confidence: 99%

“…113 And the mutation in c myc promoter reveals that this sarcoma cell 'species' has arisen in one dog decades ago and still live in a wild. 111,112 This free living cancer cell line is evolving as any other unicellular pathogen, by acquiring the ability to escape immune response. 114 Molecular Theory of Cancer …”

Section: Molecular Theory: From Molecules To Pathways To Cells To Tismentioning

confidence: 99%

Molecular theory of cancer

Blagosklonny¹

2005

Cancer Biology & Therapy

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The Canine Transmissible Venereal Tumor: a Unique Result of Tumor Progression

Cited by 131 publications

References 98 publications

Clonally transmissible cancers in dogs and Tasmanian devils

Clonally transmissible cancers in dogs and Tasmanian devils

Canine transmissible venereal tumor. The oldest clonal lineage known in nature

Molecular theory of cancer

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