In the new era, the college chemical laboratory(CCL) has developed rapidly. The safety of CCL determines the safety of personnel and facilities in CCL. This paper analyzes various elements of the safety of CCL and builds the theoretical framework for the safety assessment of the CCL based on analytic hierarchy process(AHP). Besides, we use fuzzy comprehensive evaluation(FCE) to apply the assessment model to the M college chemical laboratory(MCCL). According to the results of the safety assessment, we propose improvement strategies for the research on the safety of CCL.