1990
DOI: 10.1111/j.1365-2249.1990.tb05414.x
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The capacity of interleukin-4 to inducein vitroIgE synthesis by B cells of patients with common variable immunodeficiency

Abstract: SUMMARYInterleukin-4 (IL-4) has been shown to induce IgE synthesis by peripheral blood mononuclear cells (PBMC) of normal donors in vitro. However, induction of PBMC of patients with common variable immunodeficiency (CVI) with IL-4 resulted in IgE production in only two out of eight cases tested, PBMC of the first patient that produced IgE in response to IL-4 also secreted normal levels of IL-4 upon activation, PBMC of the second patient secreted very low levels of IL-4 in vitro which may account for the very … Show more

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Cited by 6 publications
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