The capsure database: a methodology for clinical practice and research in prostate cancer

Lubeck, Deborah P.; Litwin, Mark S.; Henning, James M.; Stier, David M.; Mazonson, Peter; Fisk, Ruth; Carroll, Peter R.

doi:10.1016/s0090-4295(96)00226-9

Cited by 259 publications

(75 citation statements)

References 18 publications

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“…A detailed description of the rigorous quality control mechanisms and database maintenance techniques in CaPSURE TM is reported elsewhere. 4 …”

Section: Methodsmentioning

confidence: 99%

“…To answer these questions we utilized data from CaPSURE TM (Cancer of the Prostate Strategic Urologic Research Endeavor), a large national database of prostate cancer patients followed in a naturalistic setting. 4 Observational databases of this type have been used successfully in the past for the study of a number of other chronic illnesses, including AIDS, 5 rheumatoid arthritis, 6 and coronary artery disease. 7 CaPSURE TM is the ®rst database of its type to study the relationship of clinical and HRQOL information in a cohort of prostate cancer patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer

Penson

Litwin

Lubeck

et al. 1998

Prostate Cancer Prostatic Dis

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Health-Related Quality of Life (HRQOL) is an important outcome measure in the study of prostate cancer. There are few data regarding the effect of sociodemographic variables, such as insurance status, educational level, marital status or income, on HRQOL. We examined whether these or other sociodemographic and clinical variables are predictive of HRQOL outcomes using an observational database of prostate cancer patients accrued from a wide array of clinical practice settings.We studied 131 patients with newly-diagnosed prostate cancer who had been followed for at least nine months. Patients were enrolled in CaPSURE TM , a large, observational database of patients with prostate cancer. General and diseasespeci®c HRQOL were measured with established, validated instruments at diagnosis and nine months later. Sociodemographic data and co-morbidity counts were recorded at baseline. Multivariate regression analysis was used to determine whether sociodemographic or clinical variables were predictive of baseline HRQOL or HRQOL changes during the study period.Several sociodemographic and clinical variables demonstrated signi®cant associations with HRQOL. We found improvements in general and diseasespeci®c domains of HRQOL during the nine months after diagnosis. For married patients, Emotional Well-Being and Family Functioning scores were better at baseline ( 11.8, P`0.02), but Family Functioning declined over the nine month study period (À18.5, P 0.0006). Older patients had slightly better baseline performance in several domains of HRQOL, but experienced greater HRQOL decrements over time than did younger patients. Increasing comorbidity was associated with worse baseline general HRQOL. Early tumor stage was predictive of better scores in general HRQOL domains at baseline. Limited palpable disease stage (T2A/T2B) was predictive of worse Sexual Function and Sexual Bother at nine months (À8.6, P 0.04; À24, P 0.008).After initial decreases, patients appear to experience an improvement in general and disease-speci®c HRQOL within nine months of initial diagnosis with prostate cancer. Marital status is associated with better HRQOL, while advancing age is associated with more signi®cant HRQOL declines over time. Patients with lower stage disease were noted to have better general HRQOL at baseline, although decreases in the physical domains were noted at nine months. These data shed new light on patients' experience with prostate cancer and suggest that HRQOL outcomes over time may occur in a predictable manner.

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“…A detailed description of the rigorous quality control mechanisms and database maintenance techniques in CaPSURE TM is reported elsewhere. 4 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer

Penson

Litwin

Lubeck

et al. 1998

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

show abstract

“…Completeness and accuracy of the data are assured by random sample chart review every 6 months. 8 A total of 8,685 patients were enrolled in the CaPSURE database between June 1, 1995, when the database was opened, and July 31, 2002. Of this group 2,387 patients were excluded from study because they had unknown or missing risk parameters of PSA at diagnosis (692, 29% of those excluded), biopsy Gleason score (327, 14%) clinical T stage (358, 15%) or multiple parameters (1010, 42%).…”

Section: Methodsmentioning

confidence: 99%

Time Trends in Clinical Risk Stratification for Prostate Cancer: Implications for Outcomes (Data From CaPSURE)

et al. 2003

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“…All patients provide written informed consent under local and central institutional review board approval [7].…”

Section: Patient Selectionmentioning

confidence: 99%

Long-term Health-related Quality of Life After Primary Treatment for Localized Prostate Cancer: Results from the CaPSURE Registry

et al. 2015

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a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e u r o p e a n u r o l o g y . c o m Outcome measurements and statistical analysis: The Medical Outcomes Studies 36-item Short Form and the University of California, Los Angeles, Prostate Cancer Index characterized physical function, mental health, and sexual, urinary, and bowel function and bother. Repeated measures mixed-model analysis assessed change in HRQOL by treatment over time, and logistic regression was used to measure the likelihood of a clinically significant decline in HRQOL. Results and limitations: Among 3294 men, 1139 (34%) underwent nerve-sparing radical prostatectomy (NSRP), 860 (26%) underwent non-NSRP, 684 (21%) underwent brachytherapy, 386 (12%) underwent external beam radiotherapy, 161 (5%) underwent primary androgen deprivation therapy, and 64 (2%) pursued watchful waiting/active surveillance. Median follow-up was 74 mo (interquartile range: 50-102). Most treatments resulted in early declines in HRQOL, with some recovery over the next 1-2 yr and a plateau in scores thereafter. Surgery had the largest impact on sexual function and bother and on urinary function, radiation had the strongest effect on bowel function, and androgen deprivation therapy had the strongest effect on physical function. The main limitation was attrition among the cohort. Conclusions: Although most men experience initial declines in HRQOL in the first 2 yr after treatment, there is little change from 3 to 10 yr and most differences between treatments attenuated over time. Patient summary: Various treatments for prostate cancer result in a distinct constellation of adverse effects on health-related quality of life, which may have a long-term impact. These findings are helpful regarding shared decision making over choice of primary treatment. Article info

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The capsure database: a methodology for clinical practice and research in prostate cancer

Cited by 259 publications

References 18 publications

Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer

Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer

Time Trends in Clinical Risk Stratification for Prostate Cancer: Implications for Outcomes (Data From CaPSURE)

Long-term Health-related Quality of Life After Primary Treatment for Localized Prostate Cancer: Results from the CaPSURE Registry

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