The Carcinogenicity of Beryllium

Kuschner, Marvin

doi:10.2307/3429224

Cited by 12 publications

(9 citation statements)

References 2 publications

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“…However, exposure to beryllium vapor or particles is associated with a number of health risks from contact dermatitis to chronic lung disease, known as chronic beryllium disease (CBD). In addition, Be and its compounds in vapor or particulate form have been shown to be carcinogenic [19][20][21]. The exact composition of nickel-based dental alloys is decisive also for the biocompatibility and for the level of the nickel cations released from contact with the human saliva.…”

Section: Ni-based Dental Alloysmentioning

confidence: 99%

Nickel-Containing Alloys for Medical Application Obtained by Methods of Mechanochemistry and Powder Metallurgy

Radev

2012

ISRN Metallurgy

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The methods of mechanochemistry, in combination with cold pressing and pressureless sintering, were used to obtain the most popular nickel-based and nickel-containing alloys used in dentistry and implantology. It was shown that the intense mechanical treatment of Ni, Ti, and Cr powders used as reagents, and the application of the above-mentioned simple powder metallurgical technique for densification allows obtaining NiCr and NiTi alloys with controlled structural properties. The nickel-based dental alloys obtained by mechanically activated sintering possess excellent mechanical, technological, and aesthetic properties. These alloys are suitable as dental restorative materials and for production of porcelain veneered constructions like crowns and bridges using the so-called metal-to-ceramic dental technique. It was shown that the method of mechanically assisted synthesis allows obtaining nanosized NiTi alloy at significantly lower temperature in comparison with the traditional high-temperature alloying. It was also shown that after 40 hours intense mechanical treatment of reagents, a direct synthesis of NiTi alloy proceeds. The product has excellent sinterability which enables to produce bodies with controlled porosity appropriate for application in implantology.

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Section: Ni-based Dental Alloysmentioning

confidence: 99%

Nickel-Containing Alloys for Medical Application Obtained by Methods of Mechanochemistry and Powder Metallurgy

Radev

2012

ISRN Metallurgy

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“…Epidemiological studies on workers exposed to beryllium and on populations living in the neighbourhood of extensive beryllium emissions demonstrate an excessive risk of lung cancer (Reviewed by Kuschner [69] and Costa et al [70] ).…”

Section: Recent Human and Animalmentioning

confidence: 99%

Cancer risk from inorganics

Swierenga¹,

Gilman

McLean

1987

Cancer Metast Rev

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Inorganic metals and minerals for which there is evidence of carcinogenicity are identified. The risk of cancer from contact with them in the work place, the general environment, and under conditions of clinical (medical) exposure is discussed. The evidence indicates that minerals and metals most often influence cancer development through their action as cocarcinogens. The relationship between the physical form of mineral fibers, smoking and carcinogenic risk is emphasized. Metals are categorized as established (As, Be, Cr, Ni), suspected (Cd, Pb) and possible carcinogens (Table 6), based on the existing in vitro, animal experimental and human epidemiological data. Cancer risk and possible modes of action of elements in each class are discussed. Views on mechanisms that may be responsible for the carcinogenicity of metals are updated and analysed. Some specific examples of cancer risks associated with the clinical use of potentially carcinogenic metals and from radioactive pharmaceuticals used in therapy and diagnosis are presented. Questions are raised as to the effectiveness of conventional dosimetry in accurately measuring risk from radiopharmaceuticals.

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“…An increased incidence of lung cancer has been observed in occupational exposure to asbestos (Villeneuve et al, 2012), benzene (Sorahan et al, 2005), cadmium (Adams et al, 2012), beryllium (Kuschner, 1981), hexavalent chromium (Beaver et al, 2009), and nickel compounds (Leem et al, 2010). Moreover, 90% of the lung cancer occurs in developed countries related to smoking, occupational factors and lifestyle (Van Tongeren et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Chronic Exposure to Chlorophenol Related Compounds in the Pesticide Production Workplace and Lung Cancer: A Meta-Analysis

Zendehdel¹,

Tayefeh-Rahimian²,

Kabir³

2014

Asian Pacific Journal of Cancer Prevention

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Background: Chlorophenols (CPs) and related phenoxyacetic acids (PAs) are pesticide groups contaminated with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during production. PAs and CPs exposure is associated with risk of cancer, but the situation regarding lung cancer has not been clearly defined. We proposed a meta-analysis of published researches to evaluate relationship between chronic exposure to PAs and CPs in pesticide production workplaces and the risk of lung cancer. Materials and Methods: After searching PubMed, Scopus, Scholar Google, Web of Sciences until August 2013, the association between chronic PAs and CPs exposure in production workplace and lung cancer was studied in 15 cohort studies. The standardized mortality rate (SMR) and 95% confidence intervals (CI) were collected from the papers. We used random or fixed-effects models, Egger test, funnel plot and meta regression in our analysis. Results: Five papers with six reports were included in the final analysis. The standardized mortality rate for lung cancer from the random model was 1.18 (95% CI: 1.03-1.35, p=0.014) with moderate heterogeneity. Publication bias was not found for included studies in meta-analysis (p=0.9). Conclusions: Our findings has strengthen the evidence of lung cancer from chronic exposure to chlorophenol related compounds (PAs, CPs).

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The Carcinogenicity of Beryllium

Cited by 12 publications

References 2 publications

Nickel-Containing Alloys for Medical Application Obtained by Methods of Mechanochemistry and Powder Metallurgy

Nickel-Containing Alloys for Medical Application Obtained by Methods of Mechanochemistry and Powder Metallurgy

Cancer risk from inorganics

Chronic Exposure to Chlorophenol Related Compounds in the Pesticide Production Workplace and Lung Cancer: A Meta-Analysis

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