The carcinogenicity of β-propiolactone and 4-nitroquinoline N-oxide for the skin of the golden hamster.

Parish, D. J.; Searle, C. E.

doi:10.1038/bjc.1966.24

Cited by 16 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rats reacted within a day of skin application of NQO by losing weight sharply, becoming irritable and showing aggressive behaviour. In contrast, applications of NQO to hamster skin were without, any noticeable toxic effects (Parish and Searle, 1966b The NZY mice were outstanding both with respect to the relatively short time needed to induce tumours and in that 13 out of 15 treated mice developed tumours. At the other extreme, not one IF mouse developed a tumour, and skin changes in the last two surviving mice were minimal.…”

Section: Discussionmentioning

confidence: 90%

“…Other experiments in these laboratories have shown marked differences in sensitivity to NQO between mice, rats, hamsters and guinea-pigs. Like mice, guinea-pigs showed signs of skin irritation after several applications of NQO, and their poor condition after several weeks or months necessitated interruption of treatment (Parish and Searle, 1966a). Rats reacted within a day of skin application of NQO by losing weight sharply, becoming irritable and showing aggressive behaviour.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin.

Searle¹,

Spencer²

1966

Br J Cancer

Self Cite

View full text Add to dashboard Cite

4-NITROQUINOLINE N-oxide (NQO), which was already known to have antifungal and mutagenic activity, was first shown to be carcinogenic by Nakahara, Fukuoka and Sugimura (1957). These authors applied the compound to the skin of 20 mixed strain mice and obtained tumours on each of the 14 which survived more than 100 days. Rather unexpectedly, the tumours on 4 of these mice were found to be sarcomas, though some difficulty was experienced in determining their exact cell type. Differences in the degree of incidental surface erosion were suggested to account for thQ production of carcinomas on some mice and sarcomas on others.The carcinogenicity of NQO for mouse skin has also been investigated by Lacassagne, Buu-Hoi and Zajdela (1961). They reported a strain difference in response to NQO, papillomas and epitheliomas being produced on their C57B1/Z mice but not on XVIInc/Z mice. However, their ascribing this effect to possible differences in the SH-content of epidermal cells of the two strains appeared to us unjustified on the evidence available, since these workers also described severe toxic reactions to the NQO applications, which resulted in progressive emaciation, cachexia and death of many mice without the production of tumours. Nakahara et al. (1957) only applied very small amounts of NQO (about 0.02 ml. of a 0-25 per cent solution in benzene 3 times a week), but their loss of 6 out of 20 mice during the first 100 days of treatment is also suggestive of marked toxicity.The present paper summarises the results of a number of separate experiments with NQO carried out in our laboratories using both random-bred mice and pure-line mice of several strains. The first experiments (I-III), using random-bred stock albinos and C57B1 x IF F1 hybrids, demonstrated toxic effects of NQO similar to those described by the earlier workers, and we also obtained some sarcomas in addition to papillomas and carcinomas. Another series of tests was then carried out in which smaller amounts of NQO were applied to the skin of these mice and of four pure-line strains of mouse, with a view to elucidating the question of strain differences in response to NQO under conditions of reduced toxicity (Experiment IV). This experiment demonstrated marked strain differences in the toxic and carcinogenic effects of NQO. Moreover, it was unexpectedly found that in some strains of mouse, sarcomas were induced in larger numbers than epithelial tumours. A further experiment (V) with one of these strains is also included in this report.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin.

Searle¹,

Spencer²

1966

Br J Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…F-Propiolacton erwies sich an der Haut von Ratten [10,11,27,28], Mäusen [4,10,25,[28][29][30][31][32], Meerschweinchen [33] und Goldhamstern [34] als ein potentes Carcinogen. Es entstanden vorwiegend fibroblastische Tumoren mit kollagenen Anteilen, histologisch als Spindelzell-, Fibro-oder Myxosarkom zu differenzieren.…”

Section: Carcinogene Wirkungunclassified

β‐Propiolacton [MAK Value Documentation in German language, 2004]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

show abstract

β‐Propiolacton [MAK Value Documentation in German language, 1977]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 5. Lieferung, Ausgabe 1977 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Carcinogene Wirkung Carcinogene Wirkung von BPL nach wiederholter subkutaner Zufuhr Tumoren nach Hautpinselung mit β‐Propiolacton Zur Frage eines MAK‐Wertes

show abstract

The carcinogenicity of β-propiolactone and 4-nitroquinoline N-oxide for the skin of the golden hamster.

Abstract: Images Figs. 1-4 Figs. 5-8

Cited by 16 publications

References 5 publications

Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin.

Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin.

β‐Propiolacton [MAK Value Documentation in German language, 2004]

β‐Propiolacton [MAK Value Documentation in German language, 1977]

Contact Info

Product

Resources

About