The cardiac effect of epinephrine during anaesthesia in hyperthyroid dogs

Israel, Jacob S.; Byles, Peter H.; Dobkin, Allen B.

doi:10.1007/bf03019139

Cited by 4 publications

(2 citation statements)

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“…[4][5][6][7] This may indicate that the rise in eortisol output during Forane anaesthesia helps to maintain the integrity and responsiveness of the myoeardium to epinephrine, s…”

Section: Discussionmentioning

confidence: 99%

Forane (Compound 469): 2. Biochemical effects of repeated administration to animals, response to bleeding, and compatibility with epinephrine

Byles

Dobkin

Ferguson

et al. 1971

Canad. Anaesth. Soc. J.

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Trm EXPERIMENTS ltEPORTED here were designed to reveal some biochemical effects which might be produced by the repeated inhalation of Forane by dogs and monkeys, and to compare its influence on the cardiac irritability of dogs with that of other halogenated anaesthetics. METHODS Biochemical Effects in DogsTwo groups of five mature, pedigreed, female beagles were used, having a mean body weight of 10.6 kg. Each of the dogs in one of these groups had an open liver biopsy taken, under thiopentone anaesthesia, a month before the experiment. These received 3 hours of anaesthesia a day on five consecutive days. The other group of beagles was anaesthetized for 4 hours a day on alternate days, up to a total of 16 hours.After food had been withheld for 12 hours, anaesthesia was induced by mask inhalation of <4 per eent Forane in oxygen, and the dogs were intubated. No premedication or muscle relaxant drugs were used. The animals were then eonneeted to a non-rebreathing system, using Fink valves, and maintained under surgical anaesthesia with spontaneous respiration for the appropriate periods by the administration of between 1.0 and 1.5 per cent Forane in oxygen. Fluotec vapourisers were used which had been recalibrated by gas chromatography. Arterial and venous blood samples were drawn immediately after induction and just before termination of anaesthesia, and these were analysed by standard techniques for the variables listed in Tables I and II. No intravenous fluids were given. The blood chemistry results were studied for evidence of changes occurring during a single day's anaesthesia, those seen between the 'start' samples on the first day and the 'start' samples on the last day, and the effects of serial removal of blood. 1,2After the last anaesthetic, those dogs that received 3 hours of anaesthesia on five successive days were sacrificed by intravenous injection of a barbiturate, and tissue specimens of liver, kidney, pancreas, small bowel, spleen, lungs, and heart were taken for gross and microscopic examination.

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“…[4][5][6][7] This may indicate that the rise in eortisol output during Forane anaesthesia helps to maintain the integrity and responsiveness of the myoeardium to epinephrine, s…”

Section: Discussionmentioning

confidence: 99%

Forane (Compound 469): 2. Biochemical effects of repeated administration to animals, response to bleeding, and compatibility with epinephrine

Byles

Dobkin

Ferguson

et al. 1971

Canad. Anaesth. Soc. J.

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“…Israel et al 15, found that a hyperthyroid state in dogs predisposed to ventricular arrhythmias under halothane anaesthesia. In our three series the controlled-toxic cases showed a higher incidence of abnormalities even after apparently adequate medical treatment pre-operatively.…”

Section: Discussionmentioning

confidence: 99%

Cardiac arrythmias during thyroid surgery

Bird¹,

Hayward²,

Howells³

et al. 1969

Anaesthesia

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Two hundred and twenty patients presenting for thyroidectomy in the New End Hospital's Surgical Endocrine unit were studied in order to find the incidence of cardiac arrythmias occurring with three common anaesthetic techniques. Each patient received the subcutaneous injection of a saline-adrenaline mixture before the start of surgery, The use of propanolol for correcting arrhythmias was evaluated.Patients of both sexes between the ages of 15 and 65 in whom no cardiovascular, respiratory or other preeexisting disease was detectable were admitted to the trial. Those patients who had toxic goitres were treated with carbimazole until they were euthyroid and this was followed by a course of Lugol's iodine immediately pre-operatively. The patients were then designated as either 'non-toxic' or 'controlled-toxic'. Pre-medication and inductionEach patient received pethidine, promethazine and atropine one hour pre-operatively in a dosage estimated to achieve a uniform degree of sedation. Before anaesthesia an ECG recording of all six standard leads was taken on a Cardiofax writer. Thereafter lead I1 was continually monitored on a Stanley Cox oscilloscope linked to the Cardiofax. Anaesthesia was induced using thiopentone, 5mg/kg, followed by suxamethonium, 50-75 mg. After inflation with oxygen the patient was intubated with a red rubber cuffed Magill tube smeared with 4 % lignocaine cream and the cuff was inflated to achieve occlusion of the trachea. In no case was the trachea sprayed with local analgesic. Series 1 100 patients Spontaneous respiration: halothane-nitrous oxide-oxygen.Following the induction as described above nitrous oxide, 6 litres/minute and oxygen 3 litres/minute, were directed through a Fluotec vaporizer

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