The Cardiac Related Thrombocytopenia

Abstract

Thrombocytopenia is a common problem in cardiovascular patients. The aetiology and management may be different than those in other populations. The drugs that are used during percutaneous coronary interventions most commonly associated with thrombocytopenia are the glycoprotein (GP) IIb/IIIa receptor inhibitors and heparin. Thienopyridines rarely cause thrombocytopenia. The platelet count falls, primarily due to platelet damage and destruction in the bypass circuit and hemodilution after open-heart surgery. Heparin is the most common drug to be implicated in thrombocytopenia in intensive care unit patients. Determining the etiology for the low platelet count is important for the implementation of appropriate management. Heparin-induced thrombocytopenia is a potentially devastating immune mediated adverse drug reaction caused by the emergence of antibodies that activate platelets in the presence of heparin. Despite thrombocytopenia, bleeding is rare; rather, HIT is strongly associated with thromboembolic complications involving both the arterial and venous systems.

Coagulopathy and Its Associated Factors Among Bleeding Diathesis Patients Attending at University of Gondar Specialized Referral Hospital, Northwest Ethiopia.

“…Coagulopathy is mostly associated with chronic diseases (23,29,36,37), parasitic infection (38), and some viral agents (30). In this study cardiac disease, and other chronic diseases were signi cantly associated with coagulopathy.…”

“…On the other hand, coagulopathy due to cardia disease is mostly related to medications that are given to the patients. The drugs that are associated with thrombocytopenia and prolonged coagulation test include glycoprotein IIb/IIIa receptor inhibitors, heparin, warfarin, and thienopyridines (29).…”

Coagulopathy and its Associated Factors among Patients with Bleeding History at the King Faisal Medical Complex in Taif City

“…Cardiac disease and diabetes mellitus (DM) are directly accompanied by bleeding disorders (Williamson et al, 2013) (Kabel, 2014). Medication for chronic diseases impacts the normal hemostasis process (Sinan, 2015). Mehta et al, (2016) reported that coagulopathy in a patient with cardiac disease is frequently due to medications that they use.…”

Magnitude of Coagulation Abnormalities and Associated Factors Among Patients with Heart Diseases at the University of Gondar Comprehensive Specialized Hospital

“… 18 However, studies confirm that platelet count is reduced in patients with CVD due to decreased production, increased destruction of platelets and platelet sequestration. 19 , 20 …”

“…18 However, studies confirm that platelet count is reduced in patients with CVD due to decreased production, increased destruction of platelets and platelet sequestration. 19,20 Heart disease is a major cause of hospitalization, death, poor physical function, and impaired quality of life due to comorbid conditions such as atrial fibrillation and stroke. 21,22 Coagulation abnormalities are at risk for developing myocardial infarction, stroke, and atherothrombotic events in the vascular beds.…”