The cardiac surgeon’s viewpoint of myocardial viability

Venneker, Edna H. G.; Eck-Smit, Berthe L. F. van; Rijk-Zwikker, Gerda L. van

doi:10.1007/978-94-011-1170-6_9

Cited by 1 publication

(2 citation statements)

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“…These animals ranged in age from 6 One dog was used as a sham where surgery was performed but the coronary artery was not ligated. This dog recovered for 1 week and underwent the same procedures for tracer administration as the other dogs.…”

Section: Thieory and Methodsmentioning

confidence: 99%

“…Since reperfusion after acute myocardial infarction often results in regions of contractile dysfunction that may ultimately recover (1)(2)(3)(4)(5), a technique to discern reversibly and irreversibly damaged tissue in the early period after infarction would aid greatly in patient management (6,7 ) . The most common currently used techniques for the determination of myocardial viability are positron emission tomography (PET) with 18F-deoxyglucose (8)(9)(10) and single photon emission computed tomography (SPIXT) with '"IT1 (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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The determination of myocardial viability using Gd‐DTPA in a canine model of acute myocardial ischemia and reperfusion

Pereira¹,

Prato²,

Wisenberg³

et al. 1996

Magnetic Resonance in Med

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The partition coefficient of Gd-DTPA was thought to vary with the amount of cellular membrane damage after an acute myocardial infarction. The relationship between the partition coefficient of Gd-DTPA (lambda) and the uptake of 201Tl (as a marker of tissue viability) was studied 2 h to 3 weeks after reperfusion of a 2-h occlusion to the left anterior descending coronary artery in a canine model. Gd-DTPA was infused as a bolus followed by a prolonged constant infusion, and this infusion protocol was optimized such that the concentration of Gd-DTPA was directly related to lambda. After this infusion, MR images of excised hearts showed regions of increased signal intensity corresponding to increased Gd-DTPA concentration. At all time points, lambda and 201Tl uptake were strongly negatively correlated indicating that lambda is an accurate indicator of myocardial viability. Furthermore, lambda in the infarcted regions was increased relative to normal regions after 2 h of reperfusion and stayed elevated up to 3 weeks. At all time points, lambda in the infarcted and normal regions were significantly different. As well, this data showed a trend that lambda in infarcted regions decreased monotonically from 1 day to 3 weeks. This trend was confirmed with MR imaging by examining the change in signal intensity of in vivo images from 4 days to 3 weeks in two animals. These results suggest that MRI with Gd-DTPA could be used to measure the extent of myocardial damage after an acute myocardial infarction.

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Section: Thieory and Methodsmentioning

confidence: 99%