The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF

Sadat, Sanga; Gehmert, Sebastian; Song, Yao‐Hua; Yen, Yasheng; Bai, Xiaowen; Gaiser, Sebastian; Klein, Helmut U.; Alt, Eckhard

doi:10.1016/j.bbrc.2007.09.058

Cited by 275 publications

(194 citation statements)

References 30 publications

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“…Moreover, some results obtained in vitro show similar effects of MSC on the regulation of apoptosis and/or proliferation of renal epithelial cells, 21 endothelial cells such as aortic cells, 22 brain microvascular cells 23 and cardiomyocytes. 24 Finally, convincing in vitro results obtained by Parekkadan et al 25 show, on the contrary, that MSC favor the death and reduce the proliferation of resident liver cells, specifically activated stellate cells. In the latter case, by limiting the activation of liver stellate cells, the authors suggest that MSC also have a therapeutic effect by preventing fibrosis.…”

Section: Discussionmentioning

confidence: 95%

Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis

et al. 2009

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Patients who undergo pelvic or abdominal radiotherapy may develop acute and/or chronic side effects resulting from gastrointestinal tract (GIT) alterations. In this study, we address the question of the regenerative capability of mesenchymal stem cells (MSC) after radiation-induced GIT injury. We also propose cellular targets of MSC therapy. We report that the infusion of human bone marrow-derived MSC (hMSC) provides a therapeutic benefit to NOD/SCID mice undergoing radiation-induced GIT failure. We observed that hMSC treatment brings about fast recovery of the small intestine (structure and function) in mice with reversible alterations and extends the life of mice with irreversible GIT disorders. The effects of hMSC are a consequence of their ability to improve the renewal capability of small intestinal epithelium. hMSC treatment favors the re-establishment of cellular homeostasis by both increasing endogenous proliferation processes (Ki67 immunostaining) and inhibiting apoptosis (TUNEL staining) of radiation-induced small intestinal epithelial cells. Our results suggest that MSC infusion may be used as a therapeutic treatment to limit radiation-induced GIT damage.

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Section: Discussionmentioning

confidence: 95%

Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis

et al. 2009

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“…Similar to other ASC applications in ischemic models, the improvement on the cardiac regeneration in these animal models was attributed to an increase in vascularization and/or a cell protective effect, namely by reducing apoptosis. Although the information is limited, Sadat and colleagues [77] identified the contribution of VEGF and IGF-1 to this phenomenon in co-culture studies using human ASCs. Through RNA silencing experiments it was possible to conclude that 62.5% of this anti-apoptotic effect was mediated by IGF, while, as expected, VEGF was mainly involved in the promotion of angiogenesis.…”

Section: Cardiac Regenerationmentioning

confidence: 99%

Adipose Tissue Derived Stem Cells Secretome: Soluble Factors and Their Roles in Regenerative Medicine

Salgado

Reis²,

Sousa³

et al. 2010

CSCR

529

217

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Stem cells have been long looked at as possible therapeutic vehicles for different health related problems. Among the different existing stem cell populations, Adipose derived Stem Cells (ASCs) have been gathering attention in the last 10 years. When compared to other stem cells populations and sources, ASCs can be easily isolated while providing higher yields upon the processing of adipose tissue. Similar to other stem cell populations, it was initially thought that the main potential of ASCs for regenerative medicine approaches was intimately related to their differentiation capability. Although this is true, there has been an increasing body of literature describing the trophic effects of ASCs on the protection, survival and differentiation of a variety of endogenous cells/tissues. Moreover, they have also shown to possess an immunomodulatory character. This effect is closely related to the ASCs' secretome and the soluble factors found within it. Molecules such as hepatocyte growth factor (HGF), granulocyte and macrophage colony stimulating factors, interleukins (ILs) 6, 7, 8 and 11, tumor necrosis factor-(TNF-), vascular endothelial growth factor (VEGF), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), adipokines and others have been identified within the ASCs' secretome. Due to its importance regarding future applications for the field of regenerative medicine, we aim, in the present review, to make a comprehensive analysis of the literature relating to the ASCs' secretome and its relevance to the immune and central nervous system, vascularization and cardiac regeneration. The concluding section will highlight some of the major challenges that remain before ASCs can be used for future clinical applications.

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“…These findings indicate that the beneficial effects of BM-MSCs on AECs can be exerted by their paracrine properties. Previous studies have shown that the paracrine factors of MSCs have anti-apoptotic effects in vitro on cardiac cells (27,28), pancreatic β cells (29) and hepatocytes (19). BM-MSCs are known to produce several epithelial specific growth factors, including HGF and KGF (17,18), which have been proven to initiate a variety of biological responses including migration, proliferation, and morpho genesis in AECs (30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis

Shen

Chen

Xiao

et al. 2014

Molecular Medicine Reports

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The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF

Cited by 275 publications

References 30 publications

Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis

Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis

Adipose Tissue Derived Stem Cells Secretome: Soluble Factors and Their Roles in Regenerative Medicine

Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis

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