The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule

Han, Jihong; Tan, Hao; Duan, Yajun; Chen, Yuanli; Zhu, Yan; Zhao, Buchang; Wang, Yong; Yang, Xinyu

doi:10.1016/j.phrs.2019.01.024

Cited by 60 publications

(48 citation statements)

References 72 publications

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“…The chemical fingerprints or the quantitative content of major active compounds in NXT and the in vivo biotransformation of the components have been investigated (Wang et al 2018;He et al 2019). In addition, numerous studies have demonstrated that NXT performed multiple protective effects on cardiovascular diseases (Zhao et al 2013;Zhong et al 2013;Han et al 2019). In our previous study, NXT protected proatherogenic animals against atherosclerosis with the improvement of serum lipid profiles and recovery of intestinal microecology imbalance (Zhang et al 2019).…”

Section: Introductionmentioning

confidence: 71%

Protective effects of Naoxintong capsule alone and in combination with ticagrelor and atorvastatin in rats with Qi deficiency and blood stasis syndrome

Zhang

Sui

Lin

et al. 2020

Pharmaceutical Biology

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Context: Naoxintong Capsule (NXT), a Chinese medicine, has been widely used for the treatment of coronary heart disease (CHD) in clinics. Objective: This study evaluated the cardioprotective effects of NXT alone and in combination with ticagrelor (TIC) and atorvastatin (ATO). Materials and methods: Qi deficiency and blood stasis rats were established by 8 weeks high fat diet feeding and 16 days exhaustive swimming and randomly divided into seven groups, that is, NXT (250, 500 and 1000 mg/kg/d), TIC (20 mg/kg/d), ATO (8 mg/kg/d), NXT (500 mg/kg/d)þTIC (20 mg/kg/d) and NXT (500 mg/kg/d)þATO (8 mg/kg/d) group, with oral administration for 12 weeks. The contents of TC,

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Section: Introductionmentioning

confidence: 71%

Protective effects of Naoxintong capsule alone and in combination with ticagrelor and atorvastatin in rats with Qi deficiency and blood stasis syndrome

Zhang

Sui

Lin

et al. 2020

Pharmaceutical Biology

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“…These TCMs are also the prescription composition of Buyang Huanwu decoction (BYHWD), a famous traditional Chinese medicine, which has been utilized to promote the recovery of neurological function in intracerebral hemorrhage for centuries [ 110 ]. BYHWT was first described in a medicine book named “Yi Lin Gai Cuo” which was published in 1830 [ 14 ]. According to the literature of TCM, Buyang Huanwu decoction has the effect of promoting blood circulation and activating energy (qi) flow.…”

Section: Discussionmentioning

confidence: 99%

“…It has been widely used in the clinical treatment and prevention of ischemic cardiocerebrovascular disease in China [ 111 ]. The “BYHWT” is comprised of seven natural materials: Astragali Radix, Angeticae Sinensis Radix, Paeoniae Radix Rubra, Pheretima, Chuanxiong Rhizoma, Carthami Flos, and Persicae Semen [ 14 ]. The principle drug is Astragali Radix; multiuse can replenish the spleen and stomach, removing blood stasis.…”

Section: Discussionmentioning

confidence: 99%

“…With a long history of thousands of years, TCM plays an important role in the treatment of complex diseases worldwide [ 13 ]. Besides China, TCM is popular not only in other parts of Asia but also in some western countries including in the USA and Australia [ 14 ]. TCM has attracted much attention because of its unique theoretical bases, which is quite different from that of western medicine.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Clinical Efficacy of Traditional Chinese Medicine in Recovery Stage of Stroke: A Systematic Review and Meta-Analysis

Zhang

Wang

et al. 2020

Cardiovascular Therapeutics

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Background. We provide an updated meta-analysis with detailed information on a combination of TCM and routine treatment. Methods. Retrieve appropriate articles with no language restrictions on keywords until 8 July 2019 in an electronic database. All trajectories are screened according to certain criteria. The quality of certified research was also evaluated. We made a detailed record of the results of the measurement. Meta-analysis was carried out by using the Revman 5.3 software. Results. Sixty-seven RCTs were included, and 6594 subjects were analyzed. Compared with routine treatment, the total effective rate (TER) of TCM combined with routine treatment was improved, and the recovery of stroke was also significantly accelerated. Regulation of blood lipids by notably shrinking the contents of TC, TG, and LDL and enhancing the levels of HDL. The levels of serum hs-CRP, WHV, and WLV decreased significantly, indicating that the expression of thrombomodulin was decreased after the comprehensive treatment of traditional Chinese medicines (TCMs). The combination of TCM treatment could enhance the protection of neural function by decreasing the NIHSS scoring while increasing the BI scoring. Paeoniae Radix Rubra, Angeticae Sinensis Radix, etc., can effectively improve the clinical symptoms of stroke convalescent patients and promote the recovery of neurological function. ACU of Baihui, Renzhong, etc., can improve the clinical rehabilitation effect of patients. However, our findings must be handled with care because of the small sample size and low quality of clinic trials cited. Other rigorous and large-scale RCTs are in need to confirm these results. Conclusion. A combination of TCM and routine treatment in the treatment of stroke could improve TER, and it is beneficial to the rehabilitation of patients in the recovery period of apoplexy. These effects can be mediated by a combination of several mechanisms. Nevertheless, due to the limitations of this study, these results should be handled with caution.

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“…Modern researches show that the pharmacological effects of NXTC mainly focus on improvement of blood rheology and blood coagulation function, anti-myocardial ischemia and ischemia/reperfusion injury, anti-atherosclerosis, anti-myocardial brosis, anti-cerebral I/R injury, improvement on learning and memory functions [3]. It is commonly used for the treatment of coronary heart disease, angina pectoris, stroke, secondary prevention of myocardial ischemia, cerebral infarction, transient ischemic attack, vertebro-basilar insu ciency, carotid atherosclerosis, and other cardiovascular and cerebrovascular diseases [4].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics comparison of four major bio-active components in normal and blood stasis rats after administration of Naoxintong Capsule by UPLC-TQ/MS

Li¹,

Chen²,

Zhang³

et al. 2020

Preprint

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Background Blood stasis is one major cause of cardiovascular and cerebrovascular diseases. Naoxintong capsule (NXTC), a Chinese patent medicine, has been widely employed in the prevention and treatment against cardiovascular and cerebrovascular diseases. However, the pharmacokinetics comparison of NXTC in normal and blood stasis rats were remain obscured. Methods Acute blood stasis rats were induced by being placed in ice-cold water during the interval between two injections of adrenaline hydrochloride. Normal and blood stasis rats were administrated of NXTC suspension at the dosage of 5 g⋅kg -1 , and blood was collected at different time points after then. Concentrations of four main components including caffeic acid, ferulic acid, formononetin and tanshinone IIA in rat plasma were quantified by UPLC-TQ/MS. The pharmacokinetic parameters were calculated by Phoenix WinNonlin v6.2 software. Results It was found that C max , AUC all , AUC INF_obs , Vz_F_obs and MRT last of ferulic acid, AUC all, Vz_F_obs and MRT last of caffeic acid in blood stasis rats were significantly different ( P < 0.05) from normal rats. Compared with normal rats, C max of ferulic acid and formononetin decreased significantly in the plasma of acute blood stasis rats, AUC all of caffeic acid and ferulic acid decreased notably, AUC INF_obs of ferulic acid decreased remarkably, Vz_F_obs and MRT last of ferulic acid and caffeic acid increased reversely. It is suggested that the absorption of the four components of NXTC in acute blood stasis rats was weakened, and the elimination time was prolonged. Conclusions The significant difference in some different parameters of the 4 NXTC components in normal and blood stasis rats might be caused by increasing of blood viscosity and slowing down of blood flow in acute blood stasis rats. The pharmacokinetic study under pathological condition provided important information for more rational use of NXTC in clinical situations.

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The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule

Cited by 60 publications

References 72 publications

Protective effects of Naoxintong capsule alone and in combination with ticagrelor and atorvastatin in rats with Qi deficiency and blood stasis syndrome

Protective effects of Naoxintong capsule alone and in combination with ticagrelor and atorvastatin in rats with Qi deficiency and blood stasis syndrome

Analysis of Clinical Efficacy of Traditional Chinese Medicine in Recovery Stage of Stroke: A Systematic Review and Meta-Analysis

Pharmacokinetics comparison of four major bio-active components in normal and blood stasis rats after administration of Naoxintong Capsule by UPLC-TQ/MS

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