The cardiovascular effects of deconditioning after endurance training in rats

Karhunen, M. K.; Rämö, M.Pauliina; Kettunen, Raimo; Hirvonen, L

doi:10.1111/j.1748-1716.1988.tb08412.x

Cited by 13 publications

(4 citation statements)

References 23 publications

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“…After a six-week sedentary period the cardiac hypertrophy induced by endurance training, with or without anabolic steroid treatment, was reversed. The increased heart rate response to isoproterenol after endurance training which has been suggested to result from altered beta-receptor function in vascular beds (Karhunen et al 1988) was not influenced by simultaneous anabolic steroid treatment. In spite of the isoproterenolinduced increase in heart rate, the endurancetrained rats were able to enhance the pumping performance of the left ventricle by increasing the diastolic filling of the heart and by decreasing the systemic vascular resistance (Karhunen et al I1 1988).…”

Section: Discussionmentioning

confidence: 91%

Anabolic steroids alter the haemodynamic effects of endurance training and deconditioning in rats

Karhunen

Rämö

Kettunen

1988

Acta Physiologica Scandinavica

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The haemodynamic effects of endurance training with or without anabolic steroid treatment (nandrolone decanoate, 5.0 mg kg-1 week-1) were studied before and after a six-week sedentary period in anaesthetized, open-chest rats during isoproterenol and CaCl2 loads. In comparison to the control group (CG I, n = 13) endurance training (TG I, n = 10) increased the resting stroke index significantly, end-diastolic pressure and during CaCl2 infusion the end-diastolic and end-systolic volumes. Peripheral resistance decreased in TG I during both inotropic loads but increased in CG I (P less than 0.01 between the groups). After combined endurance training and anabolic steroid treatment (TSG I, n = 16) the haemodynamic state was similar to that in CG I except peripheral resistance which was even higher than in CG I. The heart weight to body weight ratio was significantly greater both in TG I and TSG I than in CG I. After a six-week deconditioning period the haemodynamic values were essentially similar in endurance trained (TG II, n = 10) and in control rats (CG II, n = 12). After the sedentary period, in the simultaneously trained and anabolic steroid-treated group (TSG II, n = 13) stroke index and end-diastolic volume decreased more during isoproterenol load when compared with TG II or CG II (P less than 0.05 between the groups). Peripheral resistance was higher in the TSG II than in the two other groups. In conclusion, the enhanced pumping performance of the heart by increased left ventricular diastolic filling after endurance training is attenuated by simultaneous anabolic steroid treatment which further increases the peripheral resistance. Detraining reversed the main training effects in six weeks and simultaneous anabolic steroid treatment led to a decreased left ventricular filling and to elevated peripheral resistance after the sedentary period.

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Section: Discussionmentioning

confidence: 91%

Anabolic steroids alter the haemodynamic effects of endurance training and deconditioning in rats

Karhunen

Rämö

Kettunen

1988

Acta Physiologica Scandinavica

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“…Karhunen et al (1988) indicated that the decreased peripheral vascular resistance and the enhance blood flow during exercise training were attenuated after a detraining period. Long-term decrease in blood flow reduces the blood vessel diameter, with this change appearing to be mediated by low levels of EDRF (Langille and O¢Donnell 1988).…”

Section: Discussionmentioning

confidence: 99%

Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature

Wang

2004

Eur J Appl Physiol

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This study investigated how exercise training and detraining affect the cutaneous microvascular function and the regulatory role of endothelium-dependent dilation in skin vasculature. Ten healthy sedentary subjects cycled on an ergometer at 50% of maximal oxygen uptake (VO(2max)) for 30 min daily, 5 days a week, for 8 weeks, and then detrained for 8 weeks. Plasma nitric oxide (NO) metabolites (nitrite plus nitrate) were measured by a microplate fluorometer. The cutaneous microvascular perfusion responses to six graded levels of iontophoretically applied 1% acetylcholine (ACh) and 1% sodium nitroprusside (SNP) in the forearm skin were determined by laser Doppler. After training, (1) resting heart rate and blood pressure were reduced, whereas VO(2max), skin blood flow and cutaneous vascular conductance to acute exercise were enhanced; (2) plasma NO metabolite levels and ACh-induced cutaneous perfusion were increased; (3) skin vascular responses to SNP did not change significantly. However, detraining reversed these effects on cutaneous microvascular function and plasma NO metabolite levels. The results suggest that endothelium-dependent dilation in skin vasculature is enhanced by moderate exercise training and reversed to the pretraining state with detraining.

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“…Moreover, our results showed that deconditioning reversed the training effects on platelet function back to the pretraining state. This may be explained by the attenuation of blood flow (18) and the reversed alteration of lipoprotein patterns (20), which lower EDRF release after deconditioning.…”

Section: Discussionmentioning

confidence: 99%

Effects of chronic exercise and deconditioning on platelet function in women

Jen

Chen

1997

Journal of Applied Physiology

100

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To investigate the effects of chronic exercise and deconditioning on platelet function in women, 16 healthy sedentary women were divided into control and exercise groups. The exercise group cycled on an ergometer at 50% maximal oxygen consumption for 30 min/day, 5 days/wk, for two consecutive menstrual cycles and then were deconditioned for three menstrual cycles. During this period, platelet adhesiveness on a fibrinogen-coated surface, ADP-induced platelet aggregation and intracellular calcium concentration elevation, guanosine 3',5'-cyclic monophosphate (cGMP) content in platelets, and plasma nitric oxide metabolite levels were measured before and immediately after a progressive exercise test in the midfollicular phase. Our results indicated that, after exercise training, 1) resting heart rates and blood pressures were reduced, and exercise performance was improved; 2) resting platelet function was decreased, whereas plasma nitrite and nitrate levels and platelet cGMP contents were enhanced; and 3) the potentiation of platelet function by acute strenuous exercise was decreased, whereas the increases in plasma nitrite and nitrate levels and platelet cGMP contents were enhanced by acute exercise. Furthermore, deconditioning reversed these training effects. This implies that training-induced platelet functional changes in women in the midfollicular phase may be mediated by nitric oxide.

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The cardiovascular effects of deconditioning after endurance training in rats

Cited by 13 publications

References 23 publications

Anabolic steroids alter the haemodynamic effects of endurance training and deconditioning in rats

Anabolic steroids alter the haemodynamic effects of endurance training and deconditioning in rats

Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature

Effects of chronic exercise and deconditioning on platelet function in women

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