The cardiovascular risk factors in men with lower urinary tract symptoms

Yee, Chi‐Hang; Yip, Jenny S Y; Cheng, Nicole; Kwan, Cheuk-Hang; Li, Kai-Man; Teoh, Jeremy Yuen‐Chun; Chiu, Peter Ka‐Fung; Wong, Janet Yuen‐Ha; Chan, Eddie Shu‐Yin; Chan, Chun Man; Hou, See‐Ming; Ng, Chi‐Fai

doi:10.1007/s00345-018-2432-2

Cited by 10 publications

(3 citation statements)

References 22 publications

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“…These results are echoed in an updated and more detailed analysis of 966 men with LUTS. 18 Yee et al 18 demonstrated that the severity of LUTS was significantly positively correlated with Framingham score, which is an estimate of the risk of coronary heart disease taking into account of age, sex, smoking status, cholesterol levels, blood pressure, and hypertensive treatments. This supports the hypothesis that atherosclerosis leads to pelvis and bladder ischaemia, and that this might be one of the mechanisms leading to LUTS.…”

Section: Discussionmentioning

confidence: 99%

Survey on prevalence of lower urinary tract symptoms in an Asian population

Yee¹,

Chan²,

Teoh³

et al. 2019

Hong Kong Med J

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Lower urinary tract symptoms (LUTS) have a strong effect on socioeconomic and individual quality of life. The aim of the present study was to investigate the prevalence of LUTS in an Asian population. Methods: A telephone survey of individuals aged ≥40 years and of Chinese ethnicity was conducted. The survey included basic demographics, medical and health history, drinking habits, International Prostate Symptom Score, overactive bladder symptom score, Patient Health Questionnaire (PHQ-9) score, and Short Form (SF)-12v2 score. Results: From March to May 2017, 18 881 calls were made, of which 1543 fulfilled the inclusion criteria. In the end, 1000 successful respondents were recruited (302 men and 698 women). Age-adjusted prevalence of overactive bladder syndrome was 15.1%. The older the respondent, the more prevalent the storage symptoms and voiding symptoms (storage symptoms: r=0.434, P<0.001; voiding symptom: r=0.190, P<0.001). Presence of hypertension and diabetes were found to be significantly and positively correlated with storage and voiding symptoms. Storage and voiding symptoms were found to affect

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Section: Discussionmentioning

confidence: 99%

Survey on prevalence of lower urinary tract symptoms in an Asian population

Yee¹,

Chan²,

Teoh³

et al. 2019

Hong Kong Med J

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“…Since the MetS syndrome consists of a cluster of risk factors in cardiovascular diseases, atherosclerosis, through its related negative impact on bladder ischemia, is a potential mechanism for the development of OAB syndrome. In epidemiological studies, researchers reported that the severity of lower urinary tract symptoms is the risk factor of adverse cardiac events [ 40 ] and may increase the cardiovascular risk in terms of Framingham risk score [ 41 ], particularly in total cholesterol level. The vascular supply of the urinary bladder originates from the branches of the internal iliac artery, including superior, middle, and inferior vesical arteries.…”

Section: Chronic Bladder Ischemiamentioning

confidence: 99%

Metabolic Syndrome and Overactive Bladder Syndrome May Share Common Pathophysiologies

Hsu

Chen

et al. 2022

Biomedicines

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Metabolic syndrome (MetS) is defined by a group of cardiovascular risk factors, including impaired glucose tolerance, central obesity, hypertension, and dyslipidemia. Overactive bladder (OAB) syndrome consists of symptoms such as urinary urgency, frequency, and nocturia with or without urge incontinence. The high prevalences of metabolic syndrome (MetS) and overactive bladder (OAB) worldwide affect quality of life and cause profound negative impacts on the social economy. Accumulated evidence suggests that MetS might contribute to the underlying mechanisms for developing OAB, and MetS-associated OAB could be a subtype of OAB. However, how could these two syndromes interact with each other? Based on results of animal studies and observations in epidemiological studies, we summarized the common pathophysiologies existing between MetS and OAB, including autonomic and peripheral neuropathies, chronic ischemia, proinflammatory status, dysregulation of nutrient-sensing pathways (e.g., insulin resistance at the bladder mucosa and excessive succinate intake), and the probable role of dysbiosis. Since the MetS-associated OAB is a subtype of OAB with distinctive pathophysiologies, the regular and non-specific medications, such as antimuscarinics, beta-3 agonist, and botulinum toxin injection, might lead to unsatisfying results. Understanding the pathophysiologies of MetS-associated OAB might benefit future studies exploring novel biomarkers for diagnosis and therapeutic targets on both MetS and OAB.

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“…In Urology, we often fail to appreciate the greater picture of what men's health means. We focus expertly on diseases of the prostate and male genitourinary system, and increasingly their relationship to other organ systems, i.e., cardiovascular [1][2][3]. We now realize how metabolism and heart-health impact men's urinary and sexual function, and many urologists are screening for these non-urologic diseases [4][5][6][7][8].…”

Section: Dean Eltermanmentioning

confidence: 99%