The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health

Liu, Hong-cui; Chu, Tianyi; Chen, Lili; Gui, Wenjun; Zhu, Guonian

doi:10.1016/j.envpol.2017.05.072

Cited by 73 publications

(25 citation statements)

References 54 publications

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“…The compounds studied here all have markedly different mechanisms of toxicity. Triadimefon, which showed significant changes in toxicity between the two salinities, causes pericardial edema, elongated hearts, and downregulation of genes involved in regulating ATPase, calcium channel, and cardiac troponin C, which led to increased cardiotoxicity in Zebrafish (Danio rerio) [36]. Triadimefon has also been shown to induce hepatotoxicity through CYP enzyme-mediated toxicity in Medaka (Oryzias latipes) [32].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Salinity Alters Toxicity of Commonly Used Pesticides in a Model Euryhaline Fish Species (Menidia beryllina)

Hutton

Romain

Pedersen

et al. 2021

Toxics

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Changing salinity in estuaries due to sea level rise and altered rainfall patterns, as a result of climate change, has the potential to influence the interactions of aquatic pollutants as well as to alter their toxicity. From a chemical property point of view, ionic concentration can increase the octanol–water partition coefficient and thus decrease the water solubility of a compound. Biologically, organism physiology and enzyme metabolism are also altered at different salinities with implications for drug metabolism and toxic effects. This highlights the need to understand the influence of salinity on pesticide toxicity when assessing risk to estuarine and marine fishes, particularly considering that climate change is predicted to alter salinity regimes globally and many risk assessments and regulatory decisions are made using freshwater studies. Therefore, we exposed the Inland Silverside (Menidia beryllina) at an early life stage to seven commonly used pesticides at two salinities relevant to estuarine waters (5 PSU and 15 PSU). Triadimefon was the only compound to show a statistically significant increase in toxicity at the 15 PSU LC50. However, all compounds showed a decrease in LC50 values at the higher salinity, and all but one showed a decrease in the LC10 value. Many organisms rely on estuaries as nurseries and increased toxicity at higher salinities may mean that organisms in critical life stages of development are at risk of experiencing adverse, toxic effects. The differences in toxicity demonstrated here have important implications for organisms living within estuarine and marine ecosystems in the Anthropocene as climate change alters estuarine salinity regimes globally.

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Section: Resultsmentioning

confidence: 99%

“…It is a hepatotoxicant, with a reported environmental half-live of around two years, making it extremely persistent in the environment [35]. Penconazole and triadimefon are azole fungicides that cause cardiotoxicity across taxa and are found in surface and groundwater through runoff and spray drift [36,37].…”

Section: Introductionmentioning

confidence: 99%

Salinity Alters Toxicity of Commonly Used Pesticides in a Model Euryhaline Fish Species (Menidia beryllina)

Hutton

Romain

Pedersen

et al. 2021

Toxics

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show abstract

“…It is unknown what the specific roles of gng13b, wfikkn1, and mxd1 are as they relate to chemical exposure; however, identification of these hub genes is suggestive of their potentially important roles in mediating toxicity of some of the chemicals in our network. We also highlight three high degree Module 2 genes that might be involved in pathways associated with disruption of neurodevelopment due to FRC exposure: srgap3 , involved in neurodevelopmental processes as reviewed previously [ 48 ], tfe3a , an important transcription factor [ 49 ], and cacna1da , associated with calcium ion transport in neuronal signaling [ 50 , 51 ]. Other high degree genes associated with FRC exposure are presented in Table 4 , and the high centrality within their respective modules are suggestive of their potentially important roles in the toxicity of FRCs included in this study.…”

Section: Resultsmentioning

confidence: 99%

Gene co-expression network analysis in zebrafish reveals chemical class specific modules

et al. 2021

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Background Zebrafish is a popular animal model used for high-throughput screening of chemical hazards, however, investigations of transcriptomic mechanisms of toxicity are still needed. Here, our goal was to identify genes and biological pathways that Aryl Hydrocarbon Receptor 2 (AHR2) Activators and flame retardant chemicals (FRCs) alter in developing zebrafish. Taking advantage of a compendium of phenotypically-anchored RNA sequencing data collected from 48-h post fertilization (hpf) zebrafish, we inferred a co-expression network that grouped genes based on their transcriptional response. Results Genes responding to the FRCs and AHR2 Activators localized to distinct regions of the network, with FRCs inducing a broader response related to neurobehavior. AHR2 Activators centered in one region related to chemical stress responses. We also discovered several highly co-expressed genes in this module, including cyp1a, and we subsequently show that these genes are definitively within the AHR2 signaling pathway. Systematic removal of the two chemical types from the data, and analysis of network changes identified neurogenesis associated with FRCs, and regulation of vascular development associated with both chemical classes. We also identified highly connected genes responding specifically to each class that are potential biomarkers of exposure. Conclusions Overall, we created the first zebrafish chemical-specific gene co-expression network illuminating how chemicals alter the transcriptome relative to each other. In addition to our conclusions regarding FRCs and AHR2 Activators, our network can be leveraged by other studies investigating chemical mechanisms of toxicity.

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“…The decrease in heart rate could be due to abnormal cardiomyocyte contraction or inhibition of different ion channels that generate action potentials in cardiomyocytes (Lin, Hui, & Cheng, 2007). We assessed the genes expression profiles associated with calcium signaling pathway and cardiac muscle contraction in CMSE‐exposed zebrafish embryos, which demonstrated significant down‐regulation of these genes including calcium channel‐related genes (cacna1ab), potassium ion channel‐related genes (kcnq3), and the regulatory gene for cardiac troponin C (tnnc1a) (Liu, Chu, Chen, Gui, & Zhu, 2017). These results suggest that CMSE exposure inhibited the calcium signaling pathway and cardiac muscle contraction in zebrafish, leading to cardiac dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish

Xia

Huang³

et al. 2021

J of Applied Toxicology

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Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of Momordica cochinchinensis have been used therapeutically in traditional Chinese medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti‐ulcer effects as well as contains secondary metabolites with potential anticancer activities such as triterpenoids and saponins. Recent studies reported that water extract and ethanol extract of M. cochinchinensi seed were tested on mammals using an acute toxic classic method as OECD guidelines 420. No matter injected intravenously or intramuscularly, animals died within several days. In this study, zebrafish embryos were exposed to various doses of Cochinchina momordica seed extract (CMSE) from 2 dpf (days post fertilization, dpf) to 3 dpf. CMSE‐induced cardiotoxicity such as pericardial edema, cardiac apoptosis, increased ROS production, cardiac neutrophil infiltration, decreased blood flow velocity, and reduced expression of three marker genes of cardiac functions were found in zebrafish roughly in a dose‐dependent manner. These results suggest that CMSE may induce cardiotoxicity through pathways involved in inflammation, oxidative stress, and apoptosis.

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The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health

Cited by 73 publications

References 54 publications

Salinity Alters Toxicity of Commonly Used Pesticides in a Model Euryhaline Fish Species (Menidia beryllina)

Salinity Alters Toxicity of Commonly Used Pesticides in a Model Euryhaline Fish Species (Menidia beryllina)

Gene co-expression network analysis in zebrafish reveals chemical class specific modules

Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish

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