Mutation testing has been widely accepted as an approach to guide test case generation or to assess the effectiveness of test suites. Empirical studies have shown that mutants are representative of real faults; yet they also indicated a clear need for better, possibly customized, mutation operators and strategies. While methods to devise domain-specific or generalpurpose mutation operators from real faults exist, they are effortand error-prone, and do not help the tester to decide whether and how to mutate a given source code element. We propose a novel approach to automatically learn mutants from faults in real programs. First, our approach processes bug fixing changes using fine-grained differencing, code abstraction, and change clustering. Then, it learns mutation models using a deep learning strategy. We have trained and evaluated our technique on a set of ∼787k bug fixes mined from GitHub. Our empirical evaluation showed that our models are able to predict mutants that resemble the actual fixed bugs in between 9% and 45% of the cases, and over 98% of the automatically generated mutants are lexically and syntactically correct.Index Terms-mutation testing, deep learning, neural networks • A novel approach for learning how to mutate code from bug-fixes.• Empirical evidence that our models are able to learn diverse mutation operators that are closely related to real bugs.• Data and source code to enable replication [38].