The logistical, technical, and medical considerations involved in the aeromedical transport of the mechanically ventilated patient are considerable, and not well described in the literature. We review our experience with the prolonged (14.5 hr) air transport of a mechanically ventilated patient on a commercial airline. Practical and clinical issues are highlighted including equipment requirements and composition of the team, influences of altitude on equipment, and effects of altitude on the patient. A clear understanding of flight physiology and its impact on the patient and equipment are mandatory if one is to provide optimal care to these patients. The present report integrates our own experiences with data available from the literature, and may thus assist in both planning and undertaking any future such ventures for critically ill patients.