The cariostatic mechanisms of fluoride

Rošin-Grget, Kata

doi:10.5644/ama2006-124.85

Cited by 162 publications

(140 citation statements)

References 52 publications

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“…This material is safe and easy to use with children [Carvalho et al, 2010;Weyant et al, 2013]. However, fluoride is released slowly from the varnish [Rošin-Grget et al, 2013]. Our results showed a significant reduction in the number of caries in the OHC and OHC + FV groups compared to the control group.…”

Section: Discussionsupporting

confidence: 71%

Comparison of Oral Health Education and Fluoride Varnish to Prevent Early Childhood Caries: A Randomized Clinical Trial

Memarpour

Dadaein²,

Fakhraei³

et al. 2016

Caries Res

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Early childhood caries, a serious health problem among young children, can be prevented with effective intervention. The aim of this study was to evaluate the efficacy of oral health education and a fluoride varnish in the prevention of caries in children under the age of 3 years. For this single-blind randomized parallel group 1-year clinical trial in Shiraz, 300 children aged 12-24 months with sound primary teeth were selected and randomly divided into three groups (n = 100): (1) control: no preventive intervention; (2) oral health counseling, and (3) oral health counseling and fluoride varnish at baseline and 6 months later. At baseline and 4, 8 and 12 months after the intervention, caries risk reduction was recorded as the primary outcome. The mothers' knowledge and performance regarding oral health in children was used as a secondary outcome. A total of 260 children (mean age: 20.49 ± 7.33 months) completed the study. Compared to group 1, caries risk reduction in group 2 was 28% (95% CI: -39.05 to -17.45) and 31% in group 3 (95% CI: -41.88 to -21.73). However, there was no significant difference between groups 2 and 3 (95% CI: -8.58 to 1.47). In all groups, mothers' knowledge and performance at baseline were low; however, they increased significantly in follow-up appointments in groups 2 and 3 (p < 0.001). Oral health education increased mothers' knowledge and performance regarding oral health in children. Oral health counseling alone or associated with the use of fluoride varnish reduced the caries incidence in young children.

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Section: Discussionsupporting

confidence: 71%

Comparison of Oral Health Education and Fluoride Varnish to Prevent Early Childhood Caries: A Randomized Clinical Trial

Memarpour

Dadaein²,

Fakhraei³

et al. 2016

Caries Res

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“…Fluoride is a well-known antimicrobial and anticariogenic anion that improves the demineralization resistance of enamel and dentin by reducing the solubility of hydroxyapatite [Stoodley et al, 2008;Rošin-Grget et al, 2013]. Recent studies have reported that fluoride prevents tissue loss from the partially demineralized dentin when subjected to acid attack under erosive conditions [Schlueter et al, 2007[Schlueter et al, , 2009Diamanti et al, 2010;Ganss et al, 2010].…”

mentioning

confidence: 99%

NaF Inhibits Matrix-Bound Cathepsin-Mediated Dentin Matrix Degradation

et al. 2016

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Matrix metalloproteinases (MMPs) and cysteine cathepsins (CCs) degrade the collagen fibrils of demineralized dentin. Sodium fluoride (NaF) has previously been shown to inhibit recombinant MMP-2 and MMP-9. This study aimed to evaluate the efficacy of NaF on the inhibition of dentin-bound MMPs and CCs. Dentin beams were completely demineralized in 10% phosphoric acid. The baseline total MMP activity and dry masses were measured. Beams were assigned to test groups based on similar MMP activity and dry mass (n = 10/group), and incubated in artificial saliva (control) or artificial saliva with NaF containing 6-238 mM fluoride for 1, 7 and 21 days. The dry mass loss and MMP activities were reassessed at each time point. The proteolytic activity was screened by gelatin zymography. ICTP and CTX released to the incubation medium were analyzed as indices of MMP and cathepsin K activity, respectively. The beams were examined under scanning electron microscopy. All NaF doses reduced the dry mass loss after 21 days (p < 0.05). NaF inhibition of the total MMP activity ranged between 5 and 80%. In gelatin zymography, the bands of MMP-2 and MMP-9 became less prominent with increasing NaF levels. NaF did not decrease the released ICTP (p > 0.05). Less CTX release was detected with F ≥179 mM (p < 0.05). CaF₂-like minerals were observed on the beams. High levels of NaF may slow the degradation of the dentin matrix due to the inhibition of cathepsin K. Fluoride does not seem effective in the direct inhibition of proteolysis by dentin matrix-bound MMPs.

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“…In addition, the improvement in the clinical appearance of the dental enamel can be considered a strong justification for the increased adhesion of non-cooperative patients to oral health programs [9]. fluoride varnish in the oral cavity, guidance on diet and education to parents / guardians were controlled, there was no control over other factors related to the maintenance of general health such as adequate access to health services and sanitary conditions and interest in health-related issues [5,9,11,14,27] as well as in matters related to oral health such as adequate brushing performed by parents and healthy diet [6,13]. Although the simplified Oral Hygiene index has not been calculated, little improvement in the oral hygiene standard of children was observed.…”

Section: Discussionmentioning

confidence: 99%

“…Since clinical observations have shown that WSL are reversible, especially in an environment where there is available fluoride, remineralization has become an important mechanism for reducing enamel caries lesions [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Effectiveness of Two Commercial Fluoride Varnish Formulations on the Control of White Spot Lesion in Primary Teeth: A Pilot Study

Itaborahy¹,

Machado²,

Elias³

et al. 2015

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate the in vivo clinical effectiveness of two commercial fluoride varnish formulations. Material and Methods: The sample consisted of seven children aged 2-5 years for a total of 24 active white spot lesions (WSL) in primary teeth. Children were randomly divided into two groups in accordance with the varnish used: G1 -Duraphat® -DR (n = 14 WSL); and G2 -Duofluorid XII® -DF (n = 10 WSL). Children were submitted to treatment with varnishes applied once a week for four consecutive weeks. Maximum mesiodistal and incisogengival dimensions were measured with a periodontal probe at the beginning of treatment and on the fifth week of treatment. The average between the two dimensions represented the value of the WSL dimension. The comparison of the mean final values of WSL dimensions between groups of fluoride varnishes tested was analyzed by the Mann-Whitney U test. The significance level adopted was 5%. Results: After five weeks, most WSL were ranked as inactive (G1 = 71.4% and G2 = 40%). No significant difference between G1 and G2 in relation to lesion activity was observed (p = 0.124). There was a significant decrease of 24% between initial (3.12 mm ± 1.49 mm) and final WSL dimension (2.35 mm ± 1.06 mm) (p = 0.012) in G1. In G2, there was a significant reduction of 40% in lesion dimension with initial value of 5.7 mm (± 3.82 mm) and final value of 3.4 mm (± 3.35 mm) (p = 0.013). Regarding the reduction in the WSL dimension, no significant difference between groups was observed (p = 0.931). Conclusion: Both fluoride varnish formulations tested had similar effect on the control of active white spot lesions in primary teeth.

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The cariostatic mechanisms of fluoride

Cited by 162 publications

References 52 publications

Comparison of Oral Health Education and Fluoride Varnish to Prevent Early Childhood Caries: A Randomized Clinical Trial

Comparison of Oral Health Education and Fluoride Varnish to Prevent Early Childhood Caries: A Randomized Clinical Trial

NaF Inhibits Matrix-Bound Cathepsin-Mediated Dentin Matrix Degradation

Clinical Effectiveness of Two Commercial Fluoride Varnish Formulations on the Control of White Spot Lesion in Primary Teeth: A Pilot Study

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