The carotid body and associated tumors: updated review with clinical/surgical significance

Butt, Nasir; Baek, Woong Kee; Lachkar, Stefan; Iwanaga, Joe; Mian, Asma; Blaak, Christa; Shah, Sameer B.; Griessenauer, Christoph J.; Tubbs, R. Shane; Loukas, Marios

doi:10.1080/02688697.2019.1617404

Cited by 27 publications

(51 citation statements)

References 23 publications

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“…Carotid body, a relatively small but extremely vital organelle situated at the carotid artery bifurcation, was first described by von Haller in 1743. 1 , 2 …”

Section: Discussionmentioning

confidence: 99%

“…A part of the paraganglion system, it contains a conglomeration of highly vascular and innervated chemoreceptor tissue specialized in ameliorating hypoxia, hypercapnia, and acidosis by modulating the autonomic nervous pathway. 2 - 4 These carotid bodies produce catecholamines and are said to be essential during fetal development. 2 …”

Section: Discussionmentioning

confidence: 99%

“… 2 - 4 These carotid bodies produce catecholamines and are said to be essential during fetal development. 2 …”

Section: Discussionmentioning

confidence: 99%

“…CBT, better nominated as carotid body paraganglioma, was first reported by von Luschka in 1862. 2 It could be sporadic (commonest), familial (due to mutations in succinate dehydrogenase gene), or hyperplastic (secondary to chronic hypoxia, like at high altitudes). 2 - 4 As such, bilateral disease is less common—seen more frequently in the familial (30%) than in the sporadic (5%) variety.…”

Section: Discussionmentioning

confidence: 99%

“… 2 It could be sporadic (commonest), familial (due to mutations in succinate dehydrogenase gene), or hyperplastic (secondary to chronic hypoxia, like at high altitudes). 2 - 4 As such, bilateral disease is less common—seen more frequently in the familial (30%) than in the sporadic (5%) variety. 2 - 4 Only 5%–10% eventually undergoes malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

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Bilateral Cervical Masses: Wolf in Sheep’s Clothing

Yadav¹,

Jategaonkar²

2021

Oman Med J

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“…Carotid body, a relatively small but extremely vital organelle situated at the carotid artery bifurcation, was first described by von Haller in 1743. 1 , 2 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“… 2 - 4 These carotid bodies produce catecholamines and are said to be essential during fetal development. 2 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Bilateral Cervical Masses: Wolf in Sheep’s Clothing

Yadav¹,

Jategaonkar²

2021

Oman Med J

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Current trends in carotid body tumors: Comprehensive review

et al. 2022

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Background: Carotid body tumor (CBT) is a rare neoplasm that has been increasingly studied during the last decades; nevertheless, it continues to be a topic of controversy. This review aims to provide an update on the general features of CBT and particularly review different treatment strategies and primary outcomes. Methods: Data for this literature review were identified by PubMed, Scopus, and Medline. 93 articles from the initial search were included, as well as 28 relevant studies utilizing the snowballing method; totaling 121 articles about CBT. Results: Main features such as anatomy, embryology, genetics, clinical presentation, and diagnosis of CBT are presented, followed by evidence of different treatment strategies such as radiotherapy, preoperative embolization, vascular resection, and vascular reconstruction. Main complications are also discussed. Conclusion:This review summarizes the most critical aspects regarding CBT. Future studies should compare different treatments to attain the best surgical results with lower morbidity rates.

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A variant of multiple endocrine neoplasia type 1 in a dog?

Borgonovi

Scudder²

2022

Vet Record Case Reports

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A 9-year-old male neutered Cockerpoo dog was presented with pyrexia and was diagnosed with sterile idiopathic panniculitis. During initial investigations, advanced imaging revealed a suspected left-sided cervical paraganglioma and bilateral adrenal masses. The dog underwent immunosuppression and achieved remission of the sterile idiopathic panniculitis. Bilateral adrenalectomy and paraganglioma excision were then performed. Histopathology identified bilateral adrenocortical carcinoma and cervical neuroendocrine carcinoma. Three months later, the dog was diagnosed with primary hyperparathyroidism. Despite left total thyroidectomy and parathyroidectomy, mild hypercalcaemia persisted for several months. Eight months later the dog became persistently hypokalaemic refractory to potassium supplementation, with metabolic alkalosis and systemic hypertension. The dog was euthanised 5 months later due to clinical deterioration. On postmortem examination, right parathyroid hyperplasia and metastatic neuroendocrine carcinoma involving liver, jejunum, pancreas and tracheobronchial lymph node were identified. This is the first report describing the concurrent presence of these types of endocrine neoplasms in a dog.

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The carotid body and associated tumors: updated review with clinical/surgical significance

Cited by 27 publications

References 23 publications

Bilateral Cervical Masses: Wolf in Sheep’s Clothing

Bilateral Cervical Masses: Wolf in Sheep’s Clothing

Current trends in carotid body tumors: Comprehensive review

A variant of multiple endocrine neoplasia type 1 in a dog?

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