The case against mineral oil

Becker, George L.

doi:10.1007/bf02879189

Cited by 17 publications

(4 citation statements)

References 20 publications

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“…Mineral oils might also impair the absorption of warfarin and lessen the effect of the anticoagulant 7,16,17 .…”

Section: Drugs Affecting Availability Of Vitamin Kmentioning

confidence: 99%

Interactions of Warfarin

Rehulková¹

2001

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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In this article, the author reviews and updates the basis of interactions with warfarin, illustrated with appropriate examples. The interactions with drugs, medicinal herbs and foods are summarised. 28Cholestyramine binds vitamin K in the gut, thus preventing its absorption 18 . It also decreases the absorption and may interrupt the enterohepatic recirculation of warfarin, resulting in a reduced anticoagulant effect 19,20 .Colestipol does not affect the absorption of warfarin. When colestipol is administered with warfarin, no depressant effects on blood levels are seen 21 . Drugs affecting receptor sensitivityEstrogens increase the synthesis of various clotting factors and may thus reduce the effect of anticoagulants 22, 23 . Oral contraceptives increase clotting factor concentrations and inhibit warfarin metabolism. The net effect depends on balance between these factors. Oral contraceptives are generally contraindicated in most patients taking warfarin since they are trombogenic 1, 24 .Steroids with anabolic or androgenic properties, such as oxymetholone 25, 26, 27 , stanozolol 28, 29 and danazol 30, 31, 32 , may potentiate the action of warfarin allegedly by reducing clotting factor synthesis. The 17-alpha-alkylated steroids appear to be more likely to induce this reaction than the non-substituted steroids 25, 26, 27, 33 . However, there has been a report of topically applied testosterone, which does not have 17-alpha-alkyl substituent, enhancing warfarin 34 .Diuretics may antagonise the action of warfarin by two pharmacodynamic mechanisms 18 : (a) patients in cardiac failure have impaired clotting factor synthesis due to hepatic congestion -correction of this state leads to increased clotting factor synthesis; (b) diuretics also reduce the plasma volume producing an increased concentration of clotting factors which may alter the anticoagulant effect of warfarin 35 . Chlorthalidone 36 and spironolactone 35 have both been associated with a reduction of warfarin activity probably as a consequence of diuresis concentrating the circulating clotting factors. Bumetanide, furosemide and thiazides appear to have no effect on warfarin 23 .Certain cephalosporines, such as cefotetan, cefamandole, cefoperazone, or moxalactam may cause marked hypoprothrombinemia and/or prolonged bleeding time at concurrent use with warfarin 38, 39, 40, 41 . The main mechanism of interaction consists in decreasing synthesis of vitamin K-dependent clotting factors.Clofibrate may potentiate warfarin action, probably by altering receptor sensitivity 23, 37 . Although clofibrate displaces warfarin from albumin binding sites this does not appear to be a principal mechanism of the interaction 42 .Drugs altering thyroid function may affect anticoagulant control, since rates of synthesis and degradation of clotting factors are dependent on thyroid function 7 . Thyroid compounds do enhance the activity of oral anticoagulants by increased metabolism of clotting factors 12 . Dextrothyroxine increases the anticoagulant effect of warfarin ...

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“…Mineral oils might also impair the absorption of warfarin and lessen the effect of the anticoagulant 7,16,17 .…”

Section: Drugs Affecting Availability Of Vitamin Kmentioning

confidence: 99%

Interactions of Warfarin

Rehulková¹

2001

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Prior to the advent of the fecal softening agents, mineral oil was commonly used as a lubricant to prevent impaction. However, there is ample evidence that mineral oil is not a harmless substance, as was once believed (3). Mineral oil interferes with the absorption of the fat‐soluble vitamins, interferes with digestion, gestion, may contain carcinogens, and as much as 60 per cent may be absorbed from the intestine.…”

Section: The Problemmentioning

confidence: 98%

Bowel Hygiene in the Gynecologic Geriatric Patient

Napp¹,

Donnenfeld²

1960

J American Geriatrics Society

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“…More serious disadvantages are interference with digestion and absorption by coating the food particles and the intestinal mucosa (Donald 1959); in extreme cases considerable loss of weight has been described. The system may be depleted of fat soluble vitamins, especially A and to a lesser extent D and E, and there is some danger that hypothrombinaemia may result from preventing absorption of vitamin K — a serious consequence to pregnant women and to those undergoing surgical operations (Becker 1952; Black 1953).…”

Section: The Use Of Laxativesmentioning

confidence: 99%

A Re‐educative Regimen for Chronic (functional) Constipation

Abrahams¹

1964

Int J Clinical Practice

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The case against mineral oil

Cited by 17 publications

References 20 publications

Interactions of Warfarin

Interactions of Warfarin

Bowel Hygiene in the Gynecologic Geriatric Patient

A Re‐educative Regimen for Chronic (functional) Constipation

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