In order to achieve health equity, we must implement innovative health system, public health, and policy-level interventions to address the historical root causes of structural and institutional racism embedded in our medical and social systems. A history of unconsented medical and research experimentation on vulnerable groups and residual healthcare provider biases toward minoritized patients has led to patient distrust of medical systems and poor quality of care. Historical discriminatory housing and lending policies resulted in racial residential segregation and neighborhoods with inadequate housing, healthy food access, and educational resources, resulting in present-day social determinants of health (SDOH). To reduce these disparities and achieve health equity, four disruptive healthcare innovations are recommended: (i) infuse health equity principles into clinical workflows by implementing National Culturally and Linguistically Appropriate Services Standards; (ii) address poverty-related SDOH; (iii) deliver care and recruit for research in nonclinical settings to reach marginalized communities; and (iv) leverage health system subject matter experts to advocate for health equity policies. During the COVID-19 pandemic we leveraged the diversity of our workforce to deliver bilingual and culturally tailored COVID-19 testing, education, and vaccines to the Hispanic and Black communities in nonclinical settings, the primary marginalized communities served by our health system that were also disproportionately impacted by COVID-19 infections, hospitalizations, and deaths. Now that we understand the importance of using innovative health equity strategies to reach marginalized communities, we must continue to re-engineer our healthcare systems to deliver care outside of our brick and mortar to overcome barriers in access to care and mistrust in the healthcare establishment stemming from past abuses and remaining experiences of bias.The Heckler Report, generated from the 1983-1984 Task Force on Black and Minority Health under the auspices of then US Department of Health and Human Services Secretary Margaret Heckler, was the first to comprehensively quantify and document health disparities among minoritized race/ethnic groups in the United States. 1 At that time health disparities accounted for 60,000 excess deaths each year with six causes of death accounting for more than 80% of mortality among Black and other minoritized populations: cancer, cardiovascular disease and stroke, chemical dependency (measured by deaths due to cirrhosis), diabetes, homicide and accidents (unintentional injuries), and infant mortality. 1 The report outlined recommendations to reduce health disparities, which focused on lifestyle choices and interventions to change behaviors, and the need to improve data collection not just among the Black population but also among Hispanic, Asian American, and American Indian/Alaska Native populations. It sparked several structural changes in the Department of Health and Human Services, including establi...