The Case of Chronic Myeloid Leukemia in a Child of 2 Years

Yakupova, E. V.; Krasavtseva, T. N.; Amirova, E. F.; Makhonina, A. I.

doi:10.17650/2311-1267-2017-4-3-64-66

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Chronic Phase1

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2023

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“…The experience of CML therapy in children and adolescents is limited in Russian Federation. Therefore, the existing Federal Clinical Guidelines are based on the experience of therapy in adult patients [23][24][25][26][27].…”

Section: Chronic Phasementioning

confidence: 99%

Clinical course of chronic myeloid leukemia with T315I mutation of BCR-ABL gene in pediatric and adolescent patients

Sheveleva¹,

Morozova²,

Osipova³

et al. 2023

CTT

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There is a limited number of publications on the incidence of different mutations in the BCR-ABL kinase domain, the efficacy and safety of therapy in children and adolescents with resistant forms of chronic myeloid leukemia (СML). Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still the only method able to cure the disease completely in pediatric and adolescent patients with CML, however, being associated with life-threatening complications. This article analyzes the course, treatment and outcomes of chronic myeloid leukemia in 3 pediatric patients pre-treated with tyrosine kinase inhibitors (TKI) who exhibited the T315I mutation in BCR-ABL kinase domain.

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Section: Chronic Phasementioning

confidence: 99%