The Case Report of Anaphylaxis after Treated with Bee-Venom Acupuncture

Kim, Jinhee; Kim, Min‐Soo; Lee, Ji-Young; Yeom, Seung-ryong; Kwon, Young-Dal; Kim, Dong-Woung

doi:10.18325/jkmr.2015.25.4.175

Cited by 9 publications

(7 citation statements)

References 8 publications

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“…Meanwhile, one retrospective case study reported that the mean time to onset of anaphylaxis after BV therapy was 21.75 min [111], therefore, it is necessary to monitor the patient for at least 30 min after BV treatment. One recent study reported that high levels of basal serum tryptase increased the risk of severe anaxphylaxis [110]. As per this information, even if an injection of BV did not cause anaphylaxis in the past, if the basal serum tryptase is elevated at a certain time for some reason, anaphylaxis may occur when BV is injected.…”

Section: Discussionmentioning

confidence: 98%

“…In clinics, a skin test is used to determine whether BV treatment is suitable for individual patients, however, negative results of a skin test do not always guarantee safety [109]. Furthermore, one case report showed that anaphylaxis may occur in patients who have had no adverse reaction after former BV therapy [110]. Since anaphylaxis can occur under any circumstances, an emergency kit in accordance with the guidelines for management of anaphylaxis should always be kept ready.…”

Section: Discussionmentioning

confidence: 99%

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Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Kim

Park

Lee

2019

Toxins

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Skin is larger than any other organ in humans. Like other organs, various bacterial, viral, and inflammatory diseases, as well as cancer, affect the skin. Skin diseases like acne, atopic dermatitis, and psoriasis often reduce the quality of life seriously. Therefore, effective treatment of skin disorders is important despite them not being life-threatening. Conventional medicines for skin diseases include corticosteroids and antimicrobial drugs, which are effective in treating many inflammatory and infectious skin diseases; however, there are growing concerns about the side effects of these therapies, especially during long-term use in relapsing or intractable diseases. Hence, many researchers are trying to develop alternative treatments, especially from natural sources, to resolve these limitations. Bee venom (BV) is an attractive candidate because many experimental and clinical reports show that BV exhibits anti-inflammatory, anti-apoptotic, anti-fibrotic, antibacterial, antiviral, antifungal, and anticancer effects. Here, we review the therapeutic applications of BV in skin diseases, including acne, alopecia, atopic dermatitis, melanoma, morphea, photoaging, psoriasis, wounds, wrinkles, and vitiligo. Moreover, we explore the therapeutic mechanisms of BV in the treatment of skin diseases and cytotoxic effects of BV on skin disease-causing pathogens, including bacteria, fungi and viruses.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Kim

Park

Lee

2019

Toxins

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“…Thus, BVP therapy is relatively safe. However, since cases of moderate to greater AEs have been reported after multiple exposures to BVP [ 19 ], continuous monitoring is required if repeated BVP is needed.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Adverse Events Associated with Bee Venom Pharmacopuncture in Patients Hospitalized in a Korean Hospital: A Retrospective Chart Review Study

Bae

Jung

Kwon

et al. 2022

Toxins

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In bee venom pharmacopuncture (BVP), bee venom isolated from the venom sac of bees is injected into the acupoint or muscle associated with a disease. However, the histamine component in bee venom can cause adverse events; therefore, attention is required for BVP use. This study investigated the frequency, severity and characteristics of patients developing BVP-associated adverse events. The medical records of patients treated with BVP at Kyung Hee University Korean Medicine Hospital between 1 January 2013 and 1 May 2021 were reviewed. The demographic characteristics, disease-related characteristics, treatment-related characteristics and impressions of each patient were analyzed. In this study, >50% of 4821 inpatients were hospitalized for neurological disorders. The mean age of the overall study population was 54.62 ± 16.38 years and 61% were women. The frequency of adverse events was 2.32%. The mean age in the adverse events group was 58.20 ± 16.10 years and 76% were women. Two patients experienced moderate adverse events, with no commonality between these events. Every patient recovered naturally with no sequelae. The results showed that BVP is a relatively safe therapeutic method. However, further studies are needed to determine the frequency of adverse events and identify the causality between baseline characteristics and adverse events.

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“… 6 Previous studies have focused on anaphylactic reactions; however, there are few studies on the characteristics of patients treated in an emergency department (ED) after bee stings. 7 8 9…”

Section: Introductionmentioning

confidence: 99%

Severe Systemic Reactions Following Bee Sting Injuries in Korea

et al. 2023

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Purpose Most bee sting injuries are benign, although sometimes they can result in life threatening outcomes, such as anaphylaxis and death. The purpose of this study was to investigate the epidemiologic status of bee sting injuries in Korea and to identify risk factors associated with severe systemic reactions (SSRs). Materials and Methods Cases were extracted from a multicenter retrospective registry for patients who had visited emergency departments (EDs) for bee sting injuries. SSRs were defined as hypotension or altered mental status upon ED arrival, hospitalization, or death. Patient demographics and injury characteristics were compared between SSR and non-SSR groups. Logistic regression was performed to identify risk factors for bee sting-associated SSRs, and the characteristics of fatality cases were summarized. Results Among the 9673 patients with bee sting injuries, 537 had an SSR and 38 died. The most frequent injury sites included the hands and head/face. Logistic regression analysis revealed that the occurrence of SSRs was associated with male sex [odds ratio (95% confidence interval); 1.634 (1.133–2.357)] and age [1.030 (1.020–1.041)]. Additionally, the risk of SSRs from trunk and head/face stings was high [2.858 (1.405–5.815) and 2.123 (1.333–3.382), respectively]. Bee venom acupuncture [3.685 (1.408–9.641)] and stings in the winter [4.573 (1.420–14.723)] were factors that increased the risk of SSRs. Conclusion Our findings emphasize the need for implementing safety policies and education on bee sting-related incidents to protect high-risk groups.

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The Case Report of Anaphylaxis after Treated with Bee-Venom Acupuncture

Cited by 9 publications

References 8 publications

Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Investigation of the Adverse Events Associated with Bee Venom Pharmacopuncture in Patients Hospitalized in a Korean Hospital: A Retrospective Chart Review Study

Severe Systemic Reactions Following Bee Sting Injuries in Korea

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