Abstract. We quantify uncertainty in the impacts of climate change on the discharge of Rio Grande, a major tributary of the Paraná River in South America and one of the most important basins in Brazil for water supply and hydroelectric power generation. We consider uncertainty in climate projections associated with the greenhouse-gas emission scenarios (A1b, A2, B1, B2) and increases in global mean air temperature of 1 to 6 • C for the HadCM3 GCM (Global Circulation Model) as well as uncertainties related to GCM structure. For the latter, multimodel runs using 6 GCMs (CCCMA CGCM31, CSIRO Mk30, IPSL CM4, MPI ECHAM5, NCAR CCSM30, UKMO HadGEM1) and HadCM3 as baseline, for a +2 • C increase in global mean temperature. Pattern-scaled GCM-outputs are applied to a large-scale hydrological model (MGB-IPH) of Rio Grande Basin. Based on simulations using HadCM3, mean annual river discharge increases, relative to the baseline or control run period , by +5% to +10% under the SRES emissions scenarios and from +8% to +51% with prescribed increases in global mean air temperature of between 1 and 6 • C. Substantial uncertainty in projected changes to mean river discharge (−28% to +13%) under the 2 • C warming scenario is, however, associated with the choice of GCM. We conclude that, in the case of Rio Grande Basin, the most important source of uncertainty derives from the GCM rather than the emission scenario or the magnitude of rise in mean global temperature.