The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene–Gene–Environment Study

Cao, Yanmiao; Lin, Xiaonan; Chen, Liang; Ji, Linqin; Zhang, Wenxin

doi:10.1007/s10964-018-0925-3

Cited by 16 publications

(11 citation statements)

References 82 publications

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“…However, The inheritance of depression does not follow a single-gene inheritance pattern like Huntington's disease but has a non-Mendelian, polygenic underpinning. As a complex psychological problem, depression is most likely the result of the synergistic effects of multiple genetic and environmental factors (Cao et al, 2018). In recent years, the studies of polygenic risk scores and gene-gene interaction studies have proved additive and interactive genetic effects of depression.…”

Section: Gene-environment Interaction Contribute To the Risk Of Depressionmentioning

confidence: 99%

Gender Differences in Depression: Evidence From Genetics

et al. 2020

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Compared with men, female accounts for a larger proportion of patients with depression. Behavioral genetics researches find gender differences in genetic underpinnings of depression. We found that gender differences exist in heritability and the gene associated with depression after reviewing relevant research. Both genes and gene-environment interactions contribute to the risk of depression in a gender-specific manner. We detailed the relationships between serotonin transporter gene-linked promoter region (5-HTTLPR) and depression. However, the results of these studies are very different. We explored the reasons for the contradictory conclusions and provided some suggestions for future research on the gender differences in genetic underpinnings of depression.

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Section: Gene-environment Interaction Contribute To the Risk Of Depressionmentioning

confidence: 99%

Gender Differences in Depression: Evidence From Genetics

et al. 2020

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“…No deviations from the Hardy-Weinberg equilibrium were detected for the genotypes (χ 2 (2) = 0.15, p = 0.93). Based on previous studies [42], we coded COMT genotypes as a two-level, Met carrier model (Val/Val = 1, Met/ Val, Met/ Met = 0). Table 1 depicts the descriptive statistics and correlations for all study variables.…”

Section: Descriptive Statistics and Correlationsmentioning

confidence: 99%

“…For example, a longitudinal study has shown that the Val-allele children were more likely to develop depression after exposure to high-risk nurturing environment [41]. Cao et al [42] also found that adolescents with Val/Val genotype were more sensitive to depression under negative peer relationships. Based on the theoretical and empirical evidence, it is plausible to assume that the interaction between COMT Val158Met polymorphism and harsh parenting would lead to NSSI through depressive symptoms.…”

Section: Introductionmentioning

confidence: 99%

Examining The Link Between Harsh Parenting And Non-Suicidal Self-Injury In Adolescence: The Role of The COMT Val158Met Polymorphism And Depressive Symptoms

Liu

Wang

et al. 2021

Preprint

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Background: Previous studies have suggested negative parenting environments, especially harsh parenting, is a specific risk factor for non-suicidal self-injury (NSSI). However, the potential mechanism between harsh parenting and NSSI has not been explored. Based on the experiential avoidance model and empirical researches, we aimed to examine if depressive symptoms are a mediator between harsh parenting and NSSI. Moreover, the catechol-O-methyltransferase (COMT) Val158Met polymorphism related to depressive symptoms may also exert a moderating effect on NSSI, thus, the interaction between harsh parenting and COMT were also considered in our study.Method：373 junior high school students were recruited for the study by using a longitudinal design. Adolescents answered self-report questionnaires and provided Saliva samples for DNA genotyping.Result：The results revealed that harsh parenting was positively associated with NSSI after 18 months, and this association was mediated by depressive symptoms. Moreover, the moderating role of COMT in the direct and indirect effect of harsh parenting on NSSI only among adolescents with two Val alleles. However, the relationship was not significant for Met carriers.Conclusion: Genetic variations of COMT Val158Met may be a critical candidate in understanding the development of depression and NSSI. We conclude that the Val homozygotes of the COMT Val158Met polymorphism play a susceptible role both in depressive symptoms and NSSI.

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“…A number of studies have also pointed out that the MAOA gene is associated with depression, anxiety, and stress-related disorders, as well as obsessive-compulsive disorder and other psychological disorders ( 20 – 22 ). In a cross-sectional study of a large number of Chinese adolescents with depression, it was found that catechol-O-methyltransferase ( COMT ) gene VAL158MET polymorphism, DAT1 gene rs27072 polymorphism, and the peer relationship played an important role in adolescent depression symptoms ( 23 ). In studies of healthy adults, Klaus et al found that early life stress, combined with the interaction of environmental and genetic factors, influenced individual cognitive functioning, and the COMT gene and the D2 dopamine receptor ( DRD2 ) gene mutation may increase the risk of mental illness, such as schizophrenia ( 24 , 25 ).…”

Section: Introductionmentioning

confidence: 99%

Research on the Effects of Occupational Stress and the DRD2 Gene on the Psychological Health of Workers in the Xinjiang Desert Oil Field

Jiang

Wumaier

et al. 2021

Front. Psychiatry

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Background: This study investigated the relationship between occupational stress and the mental health of people working in oil fields in the arid desert environment of Xinjiang, and revealed the causal relationship between occupational stress and psychological disorders, while furthermore exploring the relationship between psychological disorders and genetic levels.Methods: The participants of this study included oil field company workers from the Xinjiang Petroleum Administration of Karamay City, Xinjiang, who underwent occupational health examinations. The Occupational Stress Inventory Revised Edition (OSI-R) was used to measure the occupational stress of the oil workers. The mental health status of oil workers was evaluated using the Symptoms Checklist-90.Results: Occupational tasks: The total scores of the personal strain and mental health questionnaires were positively correlated with somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, terror, paranoia, and psychosis (P < 0.05). Individual coping resources and the mental health total score was negatively correlated with somatization, obsessive-compulsive symptoms, interpersonal sensitivity, anxiety, hostility, terror, paranoia, and psychosis. The following factors were identified as mental health risk factors: female gender; age 45 and above (relative to ≤30 years old); high scores on the personal strain questionnaire; occupational stress; external effort; internal investment; and high effort-low return. The following factors were identified as protective factors for mental health: Han nationality; oil transportation (relative to drilling); individual resilience; and work returns. In respect to the abnormal psychological group and the normal psychological group, statistically significant differences were found in the distribution of genotypes and allele frequencies at the rs1800497 locus (P < 0.05). The depression and paranoia scores observed between different genotype groups at the rs1800497 locus were statistically significant (P < 0.05).Conclusions: This study shows that occupational stress and the D2 dopamine receptor (DRD2) gene have an impact on the mental health of oil field workers in the arid desert environment of Xinjiang. Effort-reward imbalance and occupational stress were identified as risk factors for mental health, while rewards for work were protective factors. Higher levels of occupational stress may lead to depression and other psychological disorders, adversely affecting mental health. In oil field operators in the arid desert environment of Xinjiang, the AA genotype of the DRD2 gene in the rs1800497 locus was identified as a genotype specific to susceptibility to mental health problems, and a correlation was found between the A allele and an increased risk of psychological problems. Therefore, it is necessary to devise relevant measures to alleviate occupational stress among oil workers and increase their job rewards, so as to improve their mental health.

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The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene–Gene–Environment Study

Cited by 16 publications

References 82 publications

Gender Differences in Depression: Evidence From Genetics

Gender Differences in Depression: Evidence From Genetics

Examining The Link Between Harsh Parenting And Non-Suicidal Self-Injury In Adolescence: The Role of The COMT Val158Met Polymorphism And Depressive Symptoms

Research on the Effects of Occupational Stress and the DRD2 Gene on the Psychological Health of Workers in the Xinjiang Desert Oil Field

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